Zobrazeno 1 - 10
of 655
pro vyhledávání: '"David E. Kleiner"'
Autor:
Harish Gopalakrishna, Bilal Asif, Anjali Rai, Hari S. Conjeevaram, Maria Mironova, David E. Kleiner, Alexandra F. Freeman, Theo Heller
Publikováno v:
Case Reports in Gastroenterology, Vol 18, Iss 1, Pp 49-57 (2024)
Introduction: Prolidase deficiency is a rare autosomal recessive disorder caused by variants in the PEPD gene. Patients usually have multi-organ involvement and a wide range of clinical features including recurrent skin ulcers, dysmorphic facial feat
Externí odkaz:
https://doaj.org/article/c1b2e94d0d72459994031a1a6336314b
Autor:
Cecilia Monge, Changqing Xie, Yuta Myojin, Kelley L. Coffman‐D'Annibale, Donna Hrones, Gagandeep Brar, Sophie Wang, Anuradha Budhu, William D. Figg, Maggie Cam, Richard Finney, Elliot B. Levy, David E. Kleiner, Seth M. Steinberg, Xin Wei Wang, Bernadette Redd, Bradford J. Wood, Tim F. Greten
Publikováno v:
Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract Background Current standard of care for advanced biliary tract cancer (BTC) is gemcitabine, cisplatin plus anti‐PD1/PD‐L1, but response rates are modest. The purpose of this study was to explore the efficacy and safety of durvalumab (ant
Externí odkaz:
https://doaj.org/article/ace3cc3c93a540859188850b14cf317a
Autor:
Adriana A. de Jesus, Guibin Chen, Dan Yang, Tomas Brdicka, Natasha M. Ruth, David Bennin, Dita Cebecauerova, Hana Malcova, Helen Freeman, Neil Martin, Karel Svojgr, Murray H. Passo, Farzana Bhuyan, Sara Alehashemi, Andre T. Rastegar, Katsiaryna Uss, Lela Kardava, Bernadette Marrero, Iris Duric, Ebun Omoyinmi, Petra Peldova, Chyi-Chia Richard Lee, David E. Kleiner, Colleen M. Hadigan, Stephen M. Hewitt, Stefania Pittaluga, Carmelo Carmona-Rivera, Katherine R. Calvo, Nirali Shah, Miroslava Balascakova, Danielle L. Fink, Radana Kotalova, Zuzana Parackova, Lucie Peterkova, Daniela Kuzilkova, Vit Campr, Lucie Sramkova, Angelique Biancotto, Stephen R. Brooks, Cameron Manes, Eric Meffre, Rebecca L. Harper, Hyesun Kuehn, Mariana J. Kaplan, Paul Brogan, Sergio D. Rosenzweig, Melinda Merchant, Zuoming Deng, Anna Huttenlocher, Susan L. Moir, Douglas B. Kuhns, Manfred Boehm, Karolina Skvarova Kramarzova, Raphaela Goldbach-Mansky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases. Here the authors report a case series of three unrelated boys with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation, and i
Externí odkaz:
https://doaj.org/article/ae467ac9fc384475ae6d8259f8ad7971
Autor:
Asif Ali Hitawala MD, Christopher Redmond MD, Edward W. Cowen MD, MHSc, David E. Kleiner MD, PhD, Sarfaraz Hasni MD, Theo Heller MD
Publikováno v:
Journal of Investigative Medicine High Impact Case Reports, Vol 11 (2023)
Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive skin fibrosis. It has 2 main clinical subtypes—diffuse cutaneous scleroderma and limited cutaneous scleroderma. Non-cirrhotic portal hypertension (NCPH) is defined as pr
Externí odkaz:
https://doaj.org/article/e95cf78bb91042f298ca52644b5b5335
Autor:
Alexander H. Yang, Mai Ai Thanda Han, Niharika Samala, Bisharah S. Rizvi, Rachel Marchalik, Ohad Etzion, Elizabeth C. Wright, Ruchi Patel, Vinshi Khan, Devika Kapuria, Vikramaditya Samala Venkat, David E. Kleiner, Christopher Koh, Jennifer A. Kanakry, Christopher G. Kanakry, Steven Pavletic, Kirsten M. Williams, Theo Heller
Publikováno v:
Hepatology Communications, Vol 6, Iss 8, Pp 2210-2220 (2022)
Abstract Hepatic graft‐versus‐host disease (HGVHD) contributes significantly to morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Clinical findings and liver biomarkers are neither sensitive nor specific. The relations
Externí odkaz:
https://doaj.org/article/7cd1c5d87ffc4d649b0437a235d0fef1
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundChronic hepatitis delta virus (HDV) infection leads to a more severe hepatitis than hepatitis B virus (HBV) infection alone. Specific histological staining patterns have been described in HBV mono-infection, however this has not been extens
Externí odkaz:
https://doaj.org/article/0b235ba5ce084a0089c63ad5f25e1f50
Autor:
Ryan M. Gill, Daniela Allende, Patricia H. Belt, Cynthia A. Behling, Oscar W. Cummings, Cynthia D. Guy, Daniela Carpenter, Brent A. Neuschwander-Tetri, Arun J. Sanyal, James Tonascia, Mark L. Van Natta, Laura A. Wilson, Goro Yamada, Matthew Yeh, David E. Kleiner, for the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0033-e0033 (2023)
Background and Aims:. The NAFLD activity score was developed to measure histologic changes in NAFLD during therapeutic trials. Hepatocyte ballooning (HB) is the most specific feature in steatohepatitis diagnosis, yet the impact of variations in HB ha
Externí odkaz:
https://doaj.org/article/e064dc2fe4194521b39689b3632131c5
Autor:
Aviya Lanis, Rita Volochayev, David E. Kleiner, Anusha Vittal, Theo Heller, Lisa G. Rider, Susan Shenoi
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-5 (2022)
Abstract Background We present two cases of Nodular Regenerative Hyperplasia (NRH) associated with Juvenile Dermatomyositis (JDM). Case Presentation Case 1: A nine-year-old Caucasian male with refractory JDM and anti-NXP2 autoantibodies was diagnosed
Externí odkaz:
https://doaj.org/article/4d53fb72fa574925b7ee6cdb37432186
Autor:
Andrew P. Platt, Benjamin T. Bradley, Nadia Nasir, Sydney R. Stein, Sabrina C. Ramelli, Marcos J. Ramos-Benitez, James M. Dickey, Madeleine Purcell, Shreya Singireddy, Nicole Hays, Jocelyn Wu, Katherine Raja, Ryan Curto, Stephen J. Salipante, Claire Chisholm, Stephanie Carnes, Desiree A. Marshall, Brad T. Cookson, Kevin M. Vannella, Ronson J. Madathil, Shahabuddin Soherwardi, Michael T. McCurdy, Kapil K. Saharia, Joseph Rabin, NIH COVID-19 Autopsy Consortium, Alison Grazioli, David E. Kleiner, Stephen M. Hewitt, Joshua A. Lieberman, Daniel S. Chertow
Publikováno v:
Pathogens, Vol 12, Iss 7, p 932 (2023)
Bacterial and fungal co-infections are reported complications of coronavirus disease 2019 (COVID-19) in critically ill patients but may go unrecognized premortem due to diagnostic limitations. We compared the premortem with the postmortem detection o
Externí odkaz:
https://doaj.org/article/53657f01d4ef40ee97de0ac8d53b14e7
Autor:
Lindsay T. Fourman, Takara L. Stanley, James M. Billingsley, Shannan J. Ho Sui, Meghan N. Feldpausch, Autumn Boutin, Isabel Zheng, Colin M. McClure, Kathleen E. Corey, Martin Torriani, David E. Kleiner, Colleen M. Hadigan, Raymond T. Chung, Steven K. Grinspoon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract NAFLD is a leading comorbidity in HIV with an exaggerated course compared to the general population. Tesamorelin has been demonstrated to reduce liver fat and prevent fibrosis progression in HIV-associated NAFLD. We further showed that tesam
Externí odkaz:
https://doaj.org/article/968ba8285b7d4c9dac1b0917f40794e7