Zobrazeno 1 - 10
of 78
pro vyhledávání: '"David E. Heppner"'
Autor:
Florian Wittlinger, Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner, Brandon T. Oligny, Surbhi P. Chitnis, Tyler S. Beyett, Alexander Rasch, Brian Buckley, Daniel A. Urul, Tatiana Shaurova, Earl W. May, Erik M. Schaefer, Michael J. Eck, Pamela A. Hershberger, Antti Poso, Stefan A. Laufer, David E. Heppner
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Bivalent molecules consisting of groups connected through bridging linkers often exhibit strong target binding and unique biological effects. However, developing bivalent inhibitors with the desired activity is challenging due to the dual mo
Externí odkaz:
https://doaj.org/article/4d98b317db4743c79540cdb1697614f4
Autor:
Yoshihisa Kobayashi, Geoffrey R. Oxnard, Elizabeth F. Cohen, Navin R. Mahadevan, Joao V. Alessi, Yin P. Hung, Arrien A. Bertram, David E. Heppner, Mauricio F. Ribeiro, Karina P. Sacardo, Rodrigo Saddi, Mariana P. Macedo, Rafael B. Blasco, Jiaqi Li, Kari J. Kurppa, Tom Nguyen, Emma Voligny, Guruprasad Ananda, Roberto Chiarle, Artur Katz, Michael Y. Tolstorukov, Lynette M. Sholl, Pasi A. Jänne
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Fusion genes have been proposed as a potential mechanism of resistance to EGFR tyrosine kinase inhibitors (TKIs) in lung cancer. Here, the authors identify gene fusions that are associated with resistance to EGFR TKIs in non-small cell lung cancers,
Externí odkaz:
https://doaj.org/article/0ceddd06c4bb4ffa905cd1128f416204
Autor:
Tyler S. Beyett, Ciric To, David E. Heppner, Jaimin K. Rana, Anna M. Schmoker, Jaebong Jang, Dries J. H. De Clercq, Gabriel Gomez, David A. Scott, Nathanael S. Gray, Pasi A. Jänne, Michael J. Eck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Acquired drug resistance is common during chemotherapy. Here, the authors describe the structural basis and molecular mechanism by which allosteric and clinically approved, ATP-competitive inhibitors of EGFR synergize to overcome resistance in lung c
Externí odkaz:
https://doaj.org/article/b71e888015d54f3e90272f29edf5c334
Autor:
Blessing C. Ogboo, Uriy V. Grabovyy, Aniket Maini, Scott Scouten, Albert van der Vliet, Andrea Mattevi, David E. Heppner
Publikováno v:
Redox Biology, Vol 52, Iss , Pp 102298- (2022)
The NADPH Oxidases (NOX) catalyze the deliberate production of reactive oxygen species (ROS) and are established regulators of redox-dependent processes across diverse biological settings. Proper management of their activity is controlled through a c
Externí odkaz:
https://doaj.org/article/3ba2e227ebf44e6cae12dd33bd4a39a3
Autor:
David E. Heppner
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101934- (2021)
The Src Family Kinases (SFKs) are pivotal regulators of cellular signal transduction and highly sought-after targets in drug discovery. Their actions within cells are controlled by alterations in protein phosphorylation that switch the SFKs from auto
Externí odkaz:
https://doaj.org/article/ae573ba70ece47c5b32ee40a563e0c54
Autor:
David E. Heppner, Christopher M. Dustin, Chenyi Liao, Milena Hristova, Carmen Veith, Andrew C. Little, Bethany A. Ahlers, Sheryl L. White, Bin Deng, Ying-Wai Lam, Jianing Li, Albert van der Vliet
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The activity of several protein kinases is increased upon cellular production of reactive oxygen species, which can cause cysteine oxidation. Here the authors show that sulfenylation of specific cysteine residues within Src induce local structural ch
Externí odkaz:
https://doaj.org/article/224ec0c26833440495e8da4a22aecfde
Autor:
David E. Heppner, Milena Hristova, Tomoaki Ida, Ana Mijuskovic, Christopher M. Dustin, Virág Bogdándi, Jon M. Fukuto, Tobias P. Dick, Péter Nagy, Jianing Li, Takaaki Akaike, Albert van der Vliet
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 379-385 (2018)
The reversible oxidation of protein cysteine residues (Cys-SH) is a key reaction in cellular redox signaling involving initial formation of sulfenic acids (Cys-SOH), which are commonly detected using selective dimedone-based probes. Here, we report t
Externí odkaz:
https://doaj.org/article/898f22d00edd48fb8263a51951fa70c8
Autor:
Nicolas Chamberlain, Bethany R. Korwin-Mihavics, Emily M. Nakada, Sierra R. Bruno, David E. Heppner, David G. Chapman, Sidra M. Hoffman, Albert van der Vliet, Benjamin T. Suratt, Oliver Dienz, John F. Alcorn, Vikas Anathy
Publikováno v:
Redox Biology, Vol 22, Iss , Pp - (2019)
Protein disulfide isomerases (PDI) are a family of redox chaperones that catalyze formation or isomerization of disulfide bonds in proteins. Previous studies have shown that one member, PDIA3, interacts with influenza A virus (IAV) hemagglutinin (HA)
Externí odkaz:
https://doaj.org/article/282375a9e83041f5b51ed2149738bcfb
Autor:
David E. Heppner, Albert van der Vliet
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 24-27 (2016)
Tyrosine phosphorylation-dependent cell signaling represents a unique feature of multicellular organisms, and is important in regulation of cell differentiation and specialized cell functions. Multicellular organisms also contain a diverse family of
Externí odkaz:
https://doaj.org/article/286ff2bb5e614aab852f9ef16e94e64f
Autor:
Tyler Beyett, Ciric To, David E. Heppner, Thomas W. Gero, Nathanael S. Gray, David A. Scott, Pasi A. Jänne, Michael J. Eck
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development.