Zobrazeno 1 - 10
of 638
pro vyhledávání: '"David E. Fisher"'
Autor:
Elisabeth Roider, Alexandra I. T. Lakatos, Alicia M. McConnell, Poguang Wang, Alina Mueller, Akinori Kawakami, Jennifer Tsoi, Botond L. Szabolcs, Anna A. Ascsillán, Yusuke Suita, Vivien Igras, Jennifer A. Lo, Jennifer J. Hsiao, Rebecca Lapides, Dorottya M. P. Pál, Anna S. Lengyel, Alexander Navarini, Arimichi Okazaki, Othon Iliopoulos, István Németh, Thomas G. Graeber, Leonard Zon, Roger W. Giese, Lajos V. Kemeny, David E. Fisher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte function, development and plays a significant role in melanoma pathogenesis. MITF genomic amplification promotes melanoma development, and it can facil
Externí odkaz:
https://doaj.org/article/cc94d2d3111647cfb25391c16c6a03e3
Autor:
Kanika Kamal, David Xiang, Katherine Young, David E. Fisher, Arash Mostaghimi, Nicholas Theodosakis
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 8, Pp 2109-2117 (2024)
Abstract Introduction Limited epidemiologic data has suggested direct associations between hair pigment, race, and incidence of alopecia areata (AA). Here, we examine the relationship between natural hair color, race, and the lifetime risk alopecia.
Externí odkaz:
https://doaj.org/article/711eef10c46e41d6953e3cb2caf67320
Autor:
Sung-Hee Yoon, Mark B. Meyer, Carlos Arevalo, Murat Tekguc, Chengcheng Zhang, Jialiang S. Wang, Christian D. Castro Andrade, Katelyn Strauss, Tadatoshi Sato, Nancy A. Benkusky, Seong Min Lee, Rebecca Berdeaux, Marc Foretz, Thomas B. Sundberg, Ramnik J. Xavier, Charles H. Adelmann, Daniel J. Brooks, Anthony Anselmo, Ruslan I. Sadreyev, Ivy A. Rosales, David E. Fisher, Navin Gupta, Ryuji Morizane, Anna Greka, J. Wesley Pike, Michael Mannstadt, Marc N. Wein
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs) orchestrated
Externí odkaz:
https://doaj.org/article/807eb29db7bc4680b7215fddd31857a3
Autor:
Ziyang Xu, David E. Fisher
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The advent of mRNA vaccines represents a significant advance in the field of vaccinology. While several vaccine approaches (mRNA, DNA, recombinant protein, and viral-vectored vaccines) had been investigated at the start of the COVID-19 pandemic, mRNA
Externí odkaz:
https://doaj.org/article/914b953152034a1095beea73e27acbaa
Autor:
Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild, Xiqun Chen
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-21 (2022)
Abstract Background Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD). We previously showed that MC1R signaling can facilitate nigrostriatal dop
Externí odkaz:
https://doaj.org/article/f84f67257c0e4f8eb3eaba2a035b1cb8
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3541 (2023)
One effort to combat the rising incidence of malignant melanoma is focused on early detection by the clinical and dermoscopic screening of melanocytic nevi. However, the interaction between nevi, which are congenital or acquired benign melanocytic pr
Externí odkaz:
https://doaj.org/article/9f52035068934339924c898fba00b06e
Autor:
Joan Montero, Cécile Gstalder, Daniel J. Kim, Dorota Sadowicz, Wayne Miles, Michael Manos, Justin R. Cidado, J. Paul Secrist, Adriana E. Tron, Keith Flaherty, F. Stephen Hodi, Charles H. Yoon, Anthony Letai, David E. Fisher, Rizwan Haq
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
MAPK-targeted therapies fail to achieve complete remission. Here, the authors show that anti-apoptosis resistance is acquired in these targeted therapies through the mRNA destabilization of NOXA which leads to dependence on MCL-1, and that sequential
Externí odkaz:
https://doaj.org/article/f51e8b007adc48feb4f6169ad611de36
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The treatment of melanoma has remained a difficult challenge. Targeting the tumor stroma has recently attracted attention for developing novel strategies for melanoma therapy. Activating transcription factor 3 (ATF3) plays a crucial role in regulatin
Externí odkaz:
https://doaj.org/article/7a91b580bf4e4703b99dc194358b579d
Autor:
Sheera R. Rosenbaum, Meghan Knecht, Mehri Mollaee, Zhijiu Zhong, Dan A. Erkes, Peter A. McCue, Inna Chervoneva, Adam C. Berger, Jennifer A. Lo, David E. Fisher, Jeffrey E. Gershenwald, Michael A. Davies, Timothy J. Purwin, Andrew E. Aplin
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 510-524.e6 (2020)
Summary: Immune checkpoint inhibitors have improved patient survival in melanoma, but the innate resistance of many patients necessitates the investigation of alternative immune targets. Many immune checkpoint proteins lack proper characterization, i
Externí odkaz:
https://doaj.org/article/f3f247ef43da49c78f8d6684b25f14af
Autor:
Jessica L. Flesher, David E. Fisher
Publikováno v:
Epigenomes, Vol 5, Iss 4, p 23 (2021)
Epigenetic regulation is a crucial component of DNA maintenance and cellular identity. As our understanding of the vast array of proteins that contribute to chromatin accessibility has advanced, the role of epigenetic remodelers in disease has become
Externí odkaz:
https://doaj.org/article/3f77b4663c36427eaa96c33b6ef600af