Zobrazeno 1 - 10 of 12 pro vyhledávání: '"David E. Cowie"'
1
The PXR is a drug target for chronic inflammatory liver disease
Autor: Steven A. White, Dimitrios K. Konstantinou, David E. Cowie, Andrew A. Axon, Matthew Koruth, Torunn Elisabeth Tjelle, Derek A. Mann, Stephen John Hill, Harald Carlsen, Matthew C. Wright, Karen Wallace
Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology
PXR activators are used to treat pruritus in chronic inflammatory liver diseases such as primary biliary cirrhosis (PBC). The aims of this study were to determine whether PXR activators could have an additional benefit of inhibiting inflammation in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a5ecfd53f3529153540457c90b3eb8
https://doi.org/10.1016/j.jsbmb.2010.04.012
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3
A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: Inhibition of NF-κB?
Autor: Derek A. Mann, David E. Cowie, Andrew Axon, Matthew C. Wright
Publikováno v: Toxicology. 246:40-44
The liver is susceptible to chronic damage through exposure to a variety of toxins (e.g. alcohol) and viruses (e.g. hepatitis C). Obesity, autoimmune diseases (e.g. autoimmune hepatitis) and a variety of genetic diseases (e.g. Wilson's disease) also
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14229f0b60324a196d6ad35f7917eadb
https://doi.org/10.1016/j.tox.2007.12.008
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4
Extracorporeal membrane oxygenation for resuscitation of deceased cardiac donor livers for hepatocyte isolation
Autor: David E. Cowie, Steven A. White, S Stamp, M Noormohamed, A Kanwar, Matthew C. Wright, Christopher Ray, David Talbot, Derek Manas
Publikováno v: The Journal of surgical research. 183(2)
Background Deceased cardiac donors (DCDs) have become a useful source of organs for liver transplantation; nevertheless, there are concerns about the longevity of these grafts. The aim of this study was to evaluate the use of extracorporeal membrane
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609c3605151fc7b22318e9a71bd196f5
https://pubmed.ncbi.nlm.nih.gov/23647801
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5
The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation
Autor: Hsiou-Chi Liou, Derek A. Mann, Jelena Mann, Ahmed M. Elsharkawy, David E. Cowie, Matthew C. Wright, Alastair D. Burt, Mohammad R. Ebrahimkhani, Jorge Caamano, Fiona Oakley, Pradip Raychaudhuri, Roben G. Gieling
Publikováno v: Hepatology (Baltimore, Md.). 51(3)
In this study, we determined the role of the nuclear factor-kappaB (NF-κB) subunit c-Rel in liver injury and regeneration. In response to toxic injury of the liver, c-Rel null (c-rel−/−) mice displayed a defect in the neutrophilic inflammatory r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebb03de61af259d3dea0845bb7ed0b0
https://pubmed.ncbi.nlm.nih.gov/20058312
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