Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David E. Ambrose"'
Autor:
J. Joseph Melenhorst, Gregory M. Chen, Meng Wang, David L. Porter, Changya Chen, McKensie A. Collins, Peng Gao, Shovik Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici, Christopher L. Nobles, Sayantan Maji, Noelle V. Frey, Saar I. Gill, Alison W. Loren, Lifeng Tian, Irina Kulikovskaya, Minnal Gupta, David E. Ambrose, Megan M. Davis, Joseph A. Fraietta, Jennifer L. Brogdon, Regina M. Young, Anne Chew, Bruce L. Levine, Donald L. Siegel, Cécile Alanio, E. John Wherry, Frederic D. Bushman, Simon F. Lacey, Kai Tan, Carl H. June
Publikováno v:
Nature. 602:503-509
Autor:
J. Joseph Melenhorst, Gregory M. Chen, Meng Wang, David L. Porter, Changya Chen, McKensie A. Collins, Peng Gao, Shovik Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici, Christopher L. Nobles, Sayantan Maji, Noelle V. Frey, Saar I. Gill, Alison W. Loren, Lifeng Tian, Irina Kulikovskaya, Minnal Gupta, David E. Ambrose, Megan M. Davis, Joseph A. Fraietta, Jennifer L. Brogdon, Regina M. Young, Anne Chew, Bruce L. Levine, Donald L. Siegel, Cécile Alanio, E. John Wherry, Frederic D. Bushman, Simon F. Lacey, Kai Tan, Carl H. June
Publikováno v:
Nature. 612:E22-E22
Autor:
Irina Kulikovskaya, Christopher L. Nobles, Anne Chew, Shovik Bandyopadhyay, Noelle V. Frey, David L. Porter, David E Ambrose, Saar Gill, Lifeng Tian, Joseph A. Fraietta, Jennifer Brogdon, Sayantan Maji, Gregory M. Chen, Simon F. Lacey, Regina M. Young, Kai Tan, Peng Gao, Meng Wang, J. Joseph Melenhorst, Frederic D. Bushman, Cecile Alanio, Bruce L. Levine, Iulian Pruteanu-Malinici, Carl H. June, Don L. Siegel, E. J. Wherry, Megan Davis, Minnal Gupta
The adoptive transfer of T lymphocytes reprogrammed to target tumor cells has demonstrated significant potential in various malignancies. However, little is known about the long-term potential and the clonal stability of the infused cells. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::333c177c83697faf40703f5b503588c9
https://doi.org/10.21203/rs.3.rs-505891/v1
https://doi.org/10.21203/rs.3.rs-505891/v1
Autor:
J Joseph, Melenhorst, Gregory M, Chen, Meng, Wang, David L, Porter, Changya, Chen, McKensie A, Collins, Peng, Gao, Shovik, Bandyopadhyay, Hongxing, Sun, Ziran, Zhao, Stefan, Lundh, Iulian, Pruteanu-Malinici, Christopher L, Nobles, Sayantan, Maji, Noelle V, Frey, Saar I, Gill, Alison W, Loren, Lifeng, Tian, Irina, Kulikovskaya, Minnal, Gupta, David E, Ambrose, Megan M, Davis, Joseph A, Fraietta, Jennifer L, Brogdon, Regina M, Young, Anne, Chew, Bruce L, Levine, Donald L, Siegel, Cécile, Alanio, E John, Wherry, Frederic D, Bushman, Simon F, Lacey, Kai, Tan, Carl H, June
Publikováno v:
Nature. 602(7897)
The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated potential for treatment of various cancers
Autor:
Iulian Pruteanu-Malinici, Alina C. Boesteanu, Noelle V. Frey, Felipe Bedoya, Jennifer Brogdon, Don L. Siegel, Changfeng Zhang, F. Brad Johnson, Megan M. Davis, Edward Pequignot, Regina M. Young, Simon F. Lacey, Yan Wang, David L. Porter, Roddy S. O’Connor, Carl H. June, Sadik H. Kassim, Wei-Ting Hwang, David E Ambrose, Lifeng Tian, Joseph A. Fraietta, Corin L. Dorfmeier, Stefan Lundh, Bruce L. Levine, Jun Xu, Hans Bitter, Fang Chen, Irina Kulikovskaya, Nicholas Wilcox, Mercy Gohil, Harit Parakandi, Alexander C. Huang, E. John Wherry, Li Liu, J. Joseph Melenhorst, Elena Orlando, Minnal Gupta
Publikováno v:
Nature Medicine. 27:561-561
Autor:
Simon F. Lacey, Jamie E. DeNizio, Shantan Reddy, Rahul M. Kohli, Stefan Lundh, Irina Kulikovskaya, Jennifer J.D. Morrissette, Shelley L. Berger, Joseph A. Fraietta, Morgan A. Sammons, Yangbing Zhao, Alexandria P. Cogdill, Mercy Gohil, Marvin H. Gee, David L. Porter, Yan Wang, Enrique Lin-Shiao, Christopher L. Nobles, Xiaojun Liu, J. Joseph Melenhorst, Martha S. Jordan, David E Ambrose, Bruce L. Levine, Shannon A. Carty, Michael Kalos, Regina M. Young, Katherine A. Alexander, Frederic D. Bushman, Katherine T. Marcucci, Farzana Nazimuddin, Minnal Gupta, John K. Everett, Carl H. June, Jun Xu, K. Christopher Garcia, Fang Chen, Young Hwang, Tyler J. Reich
Cancer immunotherapy based on genetically redirecting T cells has been used successfully to treat B cell malignancies1-3. In this strategy, the T cell genome is modified by integration of viral vectors or transposons encoding chimaeric antigen recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d9594ff7433f45db65c0b1c37925dc
https://europepmc.org/articles/PMC6320248/
https://europepmc.org/articles/PMC6320248/
Autor:
Lifeng Tian, Joseph A. Fraietta, Jun Xu, Hans Bitter, Carl H. June, Iulian Pruteanu-Malinici, Edward Pequignot, Alina C. Boesteanu, Roddy S. O’Connor, Changfeng Zhang, Noelle V. Frey, Corin L. Dorfmeier, F. Brad Johnson, Simon F. Lacey, Nicholas Wilcox, Bruce L. Levine, Sadik H. Kassim, Stefan Lundh, Harit Parakandi, E. John Wherry, Megan M. Davis, J. Joseph Melenhorst, Regina M. Young, David L. Porter, Wei-Ting Hwang, Yan Wang, Felipe Bedoya, Alexander C. Huang, David E Ambrose, Li Liu, Mercy Gohil, Jennifer Brogdon, Elena Orlando, Don L. Siegel, Fang Chen, Irina Kulikovskaya, Minnal Gupta
Tolerance to self-antigens prevents the elimination of cancer by the immune system1,2. We used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance and mediate tumor rejection in patients with chronic lymphocytic leukemia (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab21abca5e0308fecf5fa6ee68f9d55
https://europepmc.org/articles/PMC6117613/
https://europepmc.org/articles/PMC6117613/
Autor:
Christopher L. Nobles, David M. Barrett, Regina M. Young, Carl H. June, David E Ambrose, Stephan A. Grupp, Bruce L. Levine, Prachi R. Patel, Jun Xu, Hans Bitter, Frederic D. Bushman, Irina Kulikovskaya, Farzana Nazimuddin, Olga Shestova, Simon F. Lacey, Joseph A. Fraietta, Shannon L. Maude, J. Joseph Melenhorst, Vijay Bhoj, Tyler J. Reich, Michael Klichinsky, Terry J. Fry, John Scholler, Saar Gill, Marco Ruella, Elena Orlando
Publikováno v:
Nature medicine. 24(10)
We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19(-) leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell during T cell manufac
Autor:
Elise A. Chong, Bruce L. Levine, J. Joseph Melenhorst, David E Ambrose, Stephen J. Schuster, Vanessa E. Gonzalez, Carl H. June, Simon F. Lacey
To the editor: Antibodies blocking the programmed death 1 receptor (PD-1) on T cells produce tumor regression in multiple cancers by disrupting the PD-L1/PD-1 (programmed death-ligand 1/programmed cell death protein 1) immune inhibitory axis.[1][1][
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff9124339e0d5110df875a1aff76ac6
https://europepmc.org/articles/PMC5391777/
https://europepmc.org/articles/PMC5391777/
Autor:
Simon F. Lacey, Lifeng Tian, David L. Porter, Joseph A. Fraietta, Noelle V. Frey, Irina Kulikovskaya, J. Joseph Melenhorst, Regina M. Young, David E Ambrose, Minnal Gupta, Frederic D. Bushman, Carl H. June, Christopher L. Nobles, Don L. Siegel
Publikováno v:
Blood. 132:699-699
We recently demonstrated that sustained remission in 41 CLL patients treated with the CD19-specific, 4-1BB/CD3zeta-signaling chimeric antigen receptor (CAR19) T-cells correlated strongly with the expansion and persistence of the engineered T cells an