Zobrazeno 1 - 10
of 65
pro vyhledávání: '"David E. Amacher"'
Autor:
David E. Amacher
Publikováno v:
Biomarkers. 19:541-552
Context: The definitive standard for the diagnosis of nonalcoholic fatty liver disease (NAFLD) is clinico-pathological correlation, but frequently the only laboratory abnormality is an elevation of serum aminotransferases.Objective: This has resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bf8fc98187b18a14a2a3e0e3529457
https://doi.org/10.3109/1354750x.2014.958535
https://doi.org/10.3109/1354750x.2014.958535
Autor:
David E Amacher
Publikováno v:
Human & Experimental Toxicology. 33:928-939
Adverse drug reactions (ADRs) can involve all tissues and organs, but liver injuries are considered among the most serious. A number of prospective, multicenter studies have confirmed a higher risk of ADRs in general among female subjects compared to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2621856c2a323d92ad5530e427e68a64
https://doi.org/10.1177/0960327113512860
https://doi.org/10.1177/0960327113512860
Autor:
David E. Amacher
Publikováno v:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 21(5)
Context The silencing or activation of cancer-associated genes by epigenetic mechanisms can ultimately lead to the clonal expansion of cancer cells. Objective The aim of this review is to summarize all relevant epigenetic biomarkers that have been pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c911d64a6e5b7c7f509cd91762b1bcb3
https://pubmed.ncbi.nlm.nih.gov/26983778
https://pubmed.ncbi.nlm.nih.gov/26983778
Autor:
Ingrid M. Pruimboom-Brees, Roy L. Kerlin, Daniel Morton, Yvonne Will, Germaine Boucher, David E. Amacher, Omar L. Francone, John C. Pettersen
Publikováno v:
Toxicologic Pathology. 40:810-818
Peroxisome proliferator-activated receptors (PPARs) represent therapeutic targets for the management of type 2 diabetes mellitus and dyslipidemia. Rodent carcinogenicity studies have revealed a link between γ and dual γ/α PPAR agonist treatment an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943db11caf458076cec87ce66b86e7e4
https://doi.org/10.1177/0192623312441406
https://doi.org/10.1177/0192623312441406
Autor:
David E Amacher
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 7:949-965
Hepatic steatosis is the histological observation of numerous lipid inclusions due to an excess accumulation of triacylglycerols. They are a concern with new therapeutic candidates because they signify altered lipid metabolism that can progress to mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0cefc65e2b8dae70a1f20be746c585
https://doi.org/10.1517/17425255.2011.577740
https://doi.org/10.1517/17425255.2011.577740
Autor:
David E. Amacher
Publikováno v:
Toxicology and Applied Pharmacology. 245:134-142
Biomarkers are biometric measurements that provide critical quantitative information about the biological condition of the animal or individual being tested. In drug safety studies, established toxicity biomarkers are used along with other convention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e2ed2ce1d096de625f1da624c93a1a
https://doi.org/10.1016/j.taap.2010.02.011
https://doi.org/10.1016/j.taap.2010.02.011
Publikováno v:
Food and Chemical Toxicology. 44:528-537
The purpose of this investigation was to examine the relationship among hepatic microsomal enzyme induction, liver weight, histological evidence of hepatic injury, and serum clinical chemistry markers of hepatic origin in the cynomolgus monkey. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89917a8d62dac787d6b8609a074dde2
https://doi.org/10.1016/j.fct.2005.08.027
https://doi.org/10.1016/j.fct.2005.08.027
Autor:
David E. Amacher
Publikováno v:
Toxicology Mechanisms and Methods. 16:385-394
The assessment of hepatic microsomal enzyme induction at the completion of preclinical toxicology studies in rodents and large mammals provides a wealth of information to the toxicologist and pharmacokineticist regarding how the drug-metabolizing sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2573f7f04e4dd21efeec94541eddb0
https://doi.org/10.1080/15376510600783791
https://doi.org/10.1080/15376510600783791
Autor:
David E. Amacher
Publikováno v:
Current Medicinal Chemistry. 12:1829-1839
Mitochondrial dysfunction is a fundamental mechanism in the pathogenesis of several significant toxicities in mammals, especially those associated with the liver, skeletal and cardiac muscle, and the central nervous system. These changes can also occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b86d9e8a1b87794a48b7302855af650
https://doi.org/10.2174/0929867054546663
https://doi.org/10.2174/0929867054546663
Autor:
Amy C. Shen, David E. Amacher, Roy L. Kerlin, James Kenneth Loy, Dominique Brees, Ingrid M. Pruimboom-Brees, Omar L. Francone, Mary Keener
Publikováno v:
Toxicologic Pathology. 33:86-91
Laser scanning cytometry (LSC) is a new technology that combines the properties and advantages of flow cytometry (FC) and immunohistochemistry (IHC), thus providing qualitative and quantitative information on protein expression with the additional pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfe7f28b06883ed8d440646455d2736
https://doi.org/10.1080/01926230590881817
https://doi.org/10.1080/01926230590881817