Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David E. Alonzo"'
Autor:
Bernard Van Eerdenbrugh, Geoff G. Z. Zhang, Yi Gao, Huaping Mo, Lynne S. Taylor, David E. Alonzo, Shweta A. Raina
Publikováno v:
Journal of Pharmaceutical Sciences. 104:1981-1992
Amorphous materials are high-energy solids that can potentially enhance the bioavailability of poorly soluble compounds. A major impediment to their widespread use as a formulation platform is the tendency of amorphous materials to crystallize. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623e679f338db74b94b8fef244104634
https://doi.org/10.1002/jps.24423
https://doi.org/10.1002/jps.24423
Autor:
Shweta A. Raina, David E. Alonzo, Yi Gao, Donghua Zhu, Lynne S. Taylor, Geoff G. Z. Zhang, Jianwei Wu, Nathaniel D. Catron
Publikováno v:
Pharmaceutical Research. 32:3350-3364
Many enabling formulations give rise to supersaturated solutions wherein the solute possesses higher thermodynamic activity gradients than the solute in a saturated solution. Since flux across a membrane is driven by solute activity rather than conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39575cc406f44fbddb96f2666416eb59
https://doi.org/10.1007/s11095-015-1712-4
https://doi.org/10.1007/s11095-015-1712-4
Publikováno v:
Molecular Pharmaceutics. 11:3565-3576
The commercial and clinical success of amorphous solid dispersions (ASD) in overcoming the low bioavailability of poorly soluble molecules has generated momentum among pharmaceutical scientists to advance the fundamental understanding of these comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17aa96dc4ecde9f93dd0fba6d28c3193
https://doi.org/10.1021/mp500333v
https://doi.org/10.1021/mp500333v
Publikováno v:
Powder Technology. 236:197-204
The goal of this study was to investigate the influence of particle size on the crystallization kinetics of amorphous felodipine powders stored below the glass transition temperature and to evaluate the role of surface versus bulk crystallization in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::705260042dbe06e42206ef0b2c99101f
https://doi.org/10.1016/j.powtec.2012.02.010
https://doi.org/10.1016/j.powtec.2012.02.010
Autor:
David E. Alonzo Parra, Wilian de Jesús Aguilar Cordero, Jorge Cerón Gómez, David Canul Rosado
Publikováno v:
Teoría y Praxis. 8:34-51
Otoch Ma’ax Yetel Kooh is a flora and fauna protected area, bordering the states of Yucatan and Quintana Roo. This is a clear example of local awareness by t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6dc7dd48d867e7634530168f2a981bc
https://doi.org/10.22403/uqroomx/typ12/02
https://doi.org/10.22403/uqroomx/typ12/02
Publikováno v:
Crystal Growth & Design. 12:1538-1547
The use of amorphous drugs to generate supersaturated solutions that have the potential to enhance oral drug delivery is currently an area of intense interest. From an in vivo performance standpoin...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9605bb35fd8ae9d4424220d1965ece9a
https://doi.org/10.1021/cg201590j
https://doi.org/10.1021/cg201590j
Publikováno v:
Pharmaceutical Research. 28:1643-1652
To critically evaluate the effect of submicron and micron-sized organic particulates on the ultraviolet (UV) absorption spectra of aqueous systems and assess the applicability of UV/Vis fiber-optic probes for in-situ concentration monitoring in the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9250d6f901f6303cbd1e31f008c76978
https://doi.org/10.1007/s11095-011-0399-4
https://doi.org/10.1007/s11095-011-0399-4
Publikováno v:
Pharmaceutical Research. 27:608-618
To investigate the underlying physical processes taking place during dissolution of amorphous pharmaceuticals and correlate them to the observed solution concentration-time profiles. Felodipine and indomethacin were used as model hydrophobic compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333ecb658c9afc4f4a0c92775b6af688
https://doi.org/10.1007/s11095-009-0021-1
https://doi.org/10.1007/s11095-009-0021-1
Publikováno v:
Pharmaceutical Research. 26:2523-2534
To evaluate drug-polymer miscibility behavior in four different drug-polymer amorphous solid dispersion systems, namely felodipine-poly(vinyl pyrrolidone) (PVP), nifedipine-PVP, ketoconazole-PVP, and felodipine-poly(acrylic acid) (PAA).Amorphous soli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdff3dffa26ca1d8501b03a2704e959e
https://doi.org/10.1007/s11095-009-9970-7
https://doi.org/10.1007/s11095-009-9970-7
Publikováno v:
Pharmaceutical research. 32(11)
Highly supersaturated aqueous solutions of poorly soluble compounds can undergo liquid-liquid phase separation (LLPS) when the concentration exceeds the “amorphous solubility”. This phenomenon has been widely observed during high throughput scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c607176e983aa588f3d4bee5c8871a8
https://pubmed.ncbi.nlm.nih.gov/26123681
https://pubmed.ncbi.nlm.nih.gov/26123681