Zobrazeno 1 - 10
of 264
pro vyhledávání: '"David E Thurston"'
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152303 (2016)
Pyrrolobenzodiazepines (PBDs) are covalent-binding DNA-interactive agents with growing importance as payloads in Antibody Drug Conjugates (ADCs). Until now, PBDs were thought to covalently bond to C2-NH2 groups of guanines in the DNA-minor groove acr
Externí odkaz:
https://doaj.org/article/f481e1a52951402a9e16790f61aff018
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105021 (2014)
The pyrrolo[2,1-c][1,4] benzodiazepines (PBDs) are a family of sequence-selective, minor-groove binding DNA-interactive agents that covalently attach to guanine residues. A recent publication in this journal (Raju et al, PloS One, 2012, 7, 4, e35920)
Externí odkaz:
https://doaj.org/article/79f8495aee1a4bf88431c711ecba7be0
Autor:
George Procopiou, Paul J. M. Jackson, Daniella di Mascio, Jennifer L. Auer, Chris Pepper, Khondaker Miraz Rahman, Keith R. Fox, David E. Thurston
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
A class of Cyclopropabenzindole-Pyridinobenzodiazepine (CBI-PDD) DNA cross-linking payloads, used in Antibody-Drug Conjugates, alkylate guanine and adenine bases in the DNA minor groove with a defined sequence selectivity.
Externí odkaz:
https://doaj.org/article/5745b8e61aa3408ca18a41c49e313d1d
Autor:
Thomas Lewis, David B. Corcoran, David E. Thurston, Peter J. Giles, Kevin Ashelford, Elisabeth J. Walsby, Christopher D. Fegan, Andrea G.S. Pepper, Khondaker Miraz Rahman, Chris Pepper
Publikováno v:
Haematologica, Vol 106, Iss 4 (2020)
Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation. In this study, we identified a group of novel C8-linked benzofused Pyrrolo[2,1-c][1,
Externí odkaz:
https://doaj.org/article/0911458f4f234882b035a6312aa7bbe9
Autor:
Philip W. Howard, David E. Thurston, Christopher Fegan, Thet Thet Lin, Christopher Pepper, Janet M. Hartley, Arnaud C. Tiberghien, Luke A. Masterson, Stephen J. Gregson, Zhizhi Chen, Marie Suggitt, Christopher R.H. Martin, Marissa Coffils, Anzu Hamaguchi, John A. Hartley
Supplementary Data from SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e04552841910414789329b4ff8923b
https://doi.org/10.1158/0008-5472.22384716
https://doi.org/10.1158/0008-5472.22384716
Autor:
Benjamina Esapa, Jiexuan Jiang, Anthony Cheung, Alicia Chenoweth, David E. Thurston, Sophia N. Karagiannis
Publikováno v:
Esapa, B, Jiang, J, Cheung, A, Chenoweth, A, Thurston, D & Karagiannis, S N 2023, ' Target Antigen Attributes and Their Contributions to Clinically Approved Antibody-Drug Conjugates (ADCs) in Haematopoietic and Solid Cancers ', Cancers, vol. 15, no. 6, 1845 . https://doi.org/10.3390/cancers15061845
Antibody drug conjugates (ADCs) are powerful anti-cancer therapies comprising an antibody joined to a cytotoxic payload through a chemical linker. ADCs exploit the specificity of antibodies for their target antigens, combined with the potency of cyto
Autor:
Paolo Andriollo, George Procopiou, Daniella M. di Mascio, Paul J. Jackson, Khondaker M. Rahman, Keith R. Fox, David E. Thurston
Publikováno v:
Cancer Research. 82:1750-1750
Antibody-Drug Conjugates (ADCs) are a fast-growing class of targeted cancer therapeutic agents with over ten approved and greater than 100 in various stages of clinical development. The pyridinobenzodiazepines (PDDs) are a new class of DNA-interactiv
Autor:
George Procopiou, Paul J. Jackson, Daniella M. di Mascio, Jennifer L. Auer, Paolo Andriollo, Ilona Pysz, Khondaker M. Rahman, Keith R. Fox, David E. Thurston
Publikováno v:
Cancer Research. 82:1749-1749
Antibody-Drug Conjugates (ADCs) are rapidly growing in importance as a targeted cancer therapy, with over ten approved, and many currently undergoing clinical trials. ADCs comprise of a cytotoxic agent (i.e., the "payload") conjugated via a chemical
Publikováno v:
Cancer Research. 82:6334-6334
Antibody-Drug Conjugates (ADCs) are a growing class of therapeutic agents for the treatment of cancer, with thirteen approved and over 100 others in clinical development. The pyridinobenzodiazepine (PDD) platform is a toolbox of sequence-selective, D
Autor:
David E. Thurston, Ilona Pysz
Publikováno v:
Chemistry and Pharmacology of Anticancer Drugs ISBN: 9781315374727
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08b45ce2af2ac14c70fab160b40addd
https://doi.org/10.1201/9781315374727-12
https://doi.org/10.1201/9781315374727-12