Zobrazeno 1 - 10
of 73
pro vyhledávání: '"David E Szymkowski"'
Autor:
Diana M Sama, Hafiz Mohmmad Abdul, Jennifer L Furman, Irina A Artiushin, David E Szymkowski, Stephen W Scheff, Christopher M Norris
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38170 (2012)
The role of tumor necrosis factor α (TNF) in neural function has been investigated extensively in several neurodegenerative conditions, but rarely in brain aging, where cognitive and physiologic changes are milder and more variable. Here, we show th
Externí odkaz:
https://doaj.org/article/9070eedaf2674801b42def61428bc4c7
Autor:
Nikos Oikonomou, Vaggelis Harokopos, Jonathan Zalevsky, Christos Valavanis, Anastasia Kotanidou, David E Szymkowski, George Kollias, Vassilis Aidinis
Publikováno v:
PLoS ONE, Vol 1, p e108 (2006)
BACKGROUND: Fibrosis, the replacement of functional tissue with excessive fibrous tissue, can occur in all the main tissues and organ systems, resulting in various pathological disorders. Idiopathic Pulmonary Fibrosis is a prototype fibrotic disease
Externí odkaz:
https://doaj.org/article/cda05222873d4929abbc7e348b42e43d
Autor:
Seung Y, Chu, Erik, Pong, Christine, Bonzon, Ning, Yu, Chaim O, Jacob, Samantha A, Chalmers, Chaim, Putterman, David E, Szymkowski, William, Stohl
Publikováno v:
Journal of Translational Autoimmunity
Engagement of Fcγ receptor IIb (FcγRIIb) suppresses B cell activation and represents a promising target for therapy in autoimmunity. Obexelimab is a non-depleting anti-human CD19 mAb with an Fc region engineered to have high affinity for human Fcγ
Autor:
John M. Robinson, Latha P. Ganesan, Dhruvi Joshi, Menakshi Bhat, Stephanie Seveau, Lars Hangartner, Qian Wu, Thushara A. Thomas, Erik Pong, Murugesan V. S. Rajaram, James M. Turman, David E. Szymkowski, Jesse J. Kwiek, Amit Sharma, Seung Y. Chu, Charu Tiwari, Dennis R. Burton, Alana M. Cheplowitz, Jonghan Kim
Publikováno v:
J Immunol
Neutralizing Abs suppress HIV infection by accelerating viral clearance from blood circulation in addition to neutralization. The elimination mechanism is largely unknown. We determined that human liver sinusoidal endothelial cells (LSEC) express Fc
Publikováno v:
Pharmacological Reports. 69:1380-1385
Inflammation in the orofacial region results in pain and is associated with many pathological states, including migraine, neuralgias and temporomandibular disorder. Although extensively studied, the mechanisms responsible for these conditions are not
Autor:
Minna Yli-Karjanmaa, Bettina Hjelm Clausen, Matilda Degn, Hans Gram Novrup, Ditte Gry Ellman, Peter Toft-Jensen, David E. Szymkowski, Allan Stensballe, Morten Meyer, Roberta Brambilla, Kate Lykke Lambertsen
Publikováno v:
Yli-Karjanmaa, M L K, Clausen, B H, Degn, M, Novrup, H G, Ellman, D G, Jensen, P T, Szymkowski, D E, Stensballe, A, Meyer, M, Brambilla, R & Lambertsen, K L 2019, ' Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice ', Frontiers in Neuroscience, vol. 13, no. JUL, 781 . https://doi.org/10.3389/fnins.2019.00781
Yli-Karjanmaa, M, Clausen, B H, Degn, M, Novrup, H G, Ellman, D G, Toft-Jensen, P, Szymkowski, D E, Stensballe, A, Meyer, M, Brambilla, R & Lambertsen, K L 2019, ' Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice ', Frontiers in Neuroscience, vol. 10, no. JUL, 781 . https://doi.org/10.3389/fnins.2019.00781
Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience
Yli-Karjanmaa, M, Clausen, B H, Degn, M, Novrup, H G, Ellman, D G, Toft-Jensen, P, Szymkowski, D E, Stensballe, A, Meyer, M, Brambilla, R & Lambertsen, K L 2019, ' Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice ', Frontiers in Neuroscience, vol. 10, no. JUL, 781 . https://doi.org/10.3389/fnins.2019.00781
Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience
Background: Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation. The objective of the present study was to test the effect of topical versus intracere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139369da2cbdb0f34126be29eac04e48
https://findresearcher.sdu.dk:8443/ws/files/155059325/Topical_administration_of_a_soluble_TNF_inhibitor_reduces_infarct_volume_after_focal_cerebral_ischemia_in_mice.pdf
https://findresearcher.sdu.dk:8443/ws/files/155059325/Topical_administration_of_a_soluble_TNF_inhibitor_reduces_infarct_volume_after_focal_cerebral_ischemia_in_mice.pdf
Autor:
David E. Szymkowski, Seung Y. Chu, William Stohl, Ning Yu, Chaim O. Jacob, Samantha A. Chalmers, Erik Weiking Pong, Chaim Putterman, Christine Bonzon
Publikováno v:
Journal of Translational Autoimmunity, Vol 4, Iss, Pp 100075-(2021)
Engagement of Fcγ receptor IIb (FcγRIIb) suppresses B cell activation and represents a promising target for therapy in autoimmunity. Obexelimab is a non-depleting anti-human CD19 mAb with an Fc region engineered to have high affinity for human Fcγ
Autor:
David E Szymkowski, Peter Sondermann
Publikováno v:
Current Opinion in Immunology. 40:78-87
The antibody Fc domain engages the small family of Fc receptors, expressed on cells of the immune system and beyond, to stimulate a rich diversity of positive and negative cell-mediated effector functions. The emergence of monoclonal antibodies for t
Autor:
Dario Motti, Roberta Brambilla, Pernille M. Madsen, John R. Bethea, Shaffiat Karmally, Kate Lykke Lambertsen, David E. Szymkowski
Publikováno v:
Madsen, P M, Motti, D, Karmally, S, Szymkoski, D E, Lambertsen, K L, Bethea, J R & Brambilla, R 2016, ' Oligodendroglial TNFR2 mediates membrane TNF-dependent repair in experimental autoimmune encephalomyelitis by promoting oligodendrocyte differentiation and remyelination ', The Journal of Neuroscience, vol. 36, no. 18, pp. 5128-5143 . https://doi.org/10.1523/JNEUROSCI.0211-16.2016
Tumor necrosis factor (TNF) is associated with the pathophysiology of various neurological disorders, including multiple sclerosis. It exists as a transmembrane form tmTNF, signaling via TNF receptor 2 (TNFR2) and TNFR1, and a soluble form, solTNF, s
Autor:
Mauro M. Teixeira, Vivian Louise Soares de Oliveira, Frederico Marianetti Soriani, Thiago Henrique Caldeira de Oliveira, Bernhard Ryffel, Leandro F.S. Bastos, Danielle G. Souza, Flávio A. Amaral, Vivian Vasconcelos Costa, Lívia D. Tavares, David E. Szymkowski, Izabela Galvão, Ana Carolina Fialho Dias
Publikováno v:
European Journal of Immunology. 46:204-211
Gout manifests as recurrent episodes of acute joint inflammation and pain due to the deposition of monosodium urate (MSU) crystals within the affected tissue in a process dependent on NLRP3 inflammasome activation. The synthesis, activation, and rele