Zobrazeno 1 - 10
of 777
pro vyhledávání: '"David E Neal"'
Autor:
Sarah Jurmeister, Antonio Ramos‐Montoya, Chiranjeevi Sandi, Nelma Pértega‐Gomes, Karan Wadhwa, Alastair D Lamb, Mark J Dunning, Jan Attig, Jason S Carroll, Lee GD Fryer, Sérgio L Felisbino, David E Neal
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 3, Pp 1-18 (2018)
Abstract Genetically engineered mouse models of cancer can be used to filter genome‐wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development and progress
Externí odkaz:
https://doaj.org/article/f4f3abda48f3447a8e0ee97abf3bc7cf
Autor:
Niedzica Camacho, Peter Van Loo, Sandra Edwards, Jonathan D Kay, Lucy Matthews, Kerstin Haase, Jeremy Clark, Nening Dennis, Sarah Thomas, Barbara Kremeyer, Jorge Zamora, Adam P Butler, Gunes Gundem, Sue Merson, Hayley Luxton, Steve Hawkins, Mohammed Ghori, Luke Marsden, Adam Lambert, Katalin Karaszi, Gill Pelvender, Charlie E Massie, Zsofia Kote-Jarai, Keiran Raine, David Jones, William J Howat, Steven Hazell, Naomi Livni, Cyril Fisher, Christopher Ogden, Pardeep Kumar, Alan Thompson, David Nicol, Erik Mayer, Tim Dudderidge, Yongwei Yu, Hongwei Zhang, Nimish C Shah, Vincent J Gnanapragasam, CRUK-ICGC Prostate Group, William Isaacs, Tapio Visakorpi, Freddie Hamdy, Dan Berney, Clare Verrill, Anne Y Warren, David C Wedge, Andrew G Lynch, Christopher S Foster, Yong Jie Lu, G Steven Bova, Hayley C Whitaker, Ultan McDermott, David E Neal, Rosalind Eeles, Colin S Cooper, Daniel S Brewer
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1007001 (2017)
A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively assess the role of th
Externí odkaz:
https://doaj.org/article/923e8bd162014727a66863bedfb19b8d
Autor:
Antonio Ramos‐Montoya, Alastair D Lamb, Roslin Russell, Thomas Carroll, Sarah Jurmeister, Nuria Galeano‐Dalmau, Charlie E Massie, Joan Boren, Helene Bon, Vasiliki Theodorou, Maria Vias, Greg L Shaw, Naomi L Sharma, Helen Ross‐Adams, Helen E Scott, Sarah L Vowler, William J Howat, Anne Y Warren, Richard F Wooster, Ian G Mills, David E Neal
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 5, Pp 651-661 (2014)
Abstract Castrate‐resistant prostate cancer (CRPC) is poorly characterized and heterogeneous and while the androgen receptor (AR) is of singular importance, other factors such as c‐Myc and the E2F family also play a role in later stage disease. H
Externí odkaz:
https://doaj.org/article/a381e788e932488b8fe13b0d3eb31910
Autor:
Richard M Martin, Jenny L Donovan, Luke Hounsome, Julia Verne, Joanna C Thorn, Emma L Turner, Eleanor Walsh, Liz Down, David E Neal, Freddie C Hamdy, Sian M Noble
Publikováno v:
BMJ Open, Vol 6, Iss 4 (2016)
Objectives To evaluate the accuracy of routine data for costing inpatient resource use in a large clinical trial and to investigate costing methodologies.Design Final-year inpatient cost profiles were derived using (1) data extracted from medical rec
Externí odkaz:
https://doaj.org/article/fd1206a7e74b46f49ba81a914864c96a
Autor:
Andrew J Simpkin, Leila Rooshenas, Julia Wade, Jenny L Donovan, J Athene Lane, Richard M Martin, Chris Metcalfe, Peter C Albertsen, Freddie C Hamdy, Lars Holmberg, David E Neal, Kate Tilling
Publikováno v:
Health Services and Delivery Research, Vol 3, Iss 30 (2015)
Background: Active surveillance [(AS), sometimes called active monitoring (AM)],is a National Institute for Health and Care Excellence-recommended management option for men with clinically localised prostate cancer (PCa). It aims to target radical tr
Externí odkaz:
https://doaj.org/article/9297775ec62e46c4a3b863f0bb8df261
Autor:
Rebecca Gilbert, Richard M Martin, David M Evans, Kate Tilling, George Davey Smith, John P Kemp, J Athene Lane, Freddie C Hamdy, David E Neal, Jenny L Donovan, Chris Metcalfe
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0136735 (2015)
INTRODUCTION:Prostate-specific antigen (PSA) testing is a widely accepted screening method for prostate cancer, but with low specificity at thresholds giving good sensitivity. Previous research identified four single nucleotide polymorphisms (SNPs) p
Externí odkaz:
https://doaj.org/article/a832a8046efc4f98a30eac5419da371b
Autor:
Edward J Saunders, Tokhir Dadaev, Daniel A Leongamornlert, Sarah Jugurnauth-Little, Malgorzata Tymrakiewicz, Fredrik Wiklund, Ali Amin Al Olama, Sara Benlloch, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Gianluca Severi, Henrik Gronberg, Markus Aly, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Børge G Nordestgaard, Federico Canzian, Daniele Campa, Elio Riboli, Tim J Key, Ruth C Travis, Sue A Ingles, Esther M John, Richard B Hayes, Paul Pharoah, Kay-Tee Khaw, Janet L Stanford, Elaine A Ostrander, Lisa B Signorello, Stephen N Thibodeau, Daniel Schaid, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Judith A Clements, Manuel R Teixeira, Jianfeng Xu, Christos Mikropoulos, Chee Goh, Koveela Govindasami, Michelle Guy, Rosemary A Wilkinson, Emma J Sawyer, Angela Morgan, COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative, UK Genetic Prostate Cancer Study Collaborators, UK ProtecT Study Collaborators, PRACTICAL Consortium, Douglas F Easton, Ken Muir, Rosalind A Eeles, Zsofia Kote-Jarai
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004129 (2014)
The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the HOXB genetic locus at 17q21 and
Externí odkaz:
https://doaj.org/article/ef4e48a676e14b05b1bb979807ceb684
Autor:
Pei-Hsuan Weng, Yi-Ling Huang, John H Page, Jen-Hau Chen, Jianfeng Xu, Stella Koutros, Sonja Berndt, Stephen Chanock, Meredith Yeager, John S Witte, Rosalind A Eeles, Douglas F Easton, David E Neal, Jenny Donovan, Freddie C Hamdy, Kenneth R Muir, Graham Giles, Gianluca Severi, Jeffrey R Smith, Carmela R Balistreri, Irene M Shui, Yen-Ching Chen
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110569 (2014)
Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysi
Externí odkaz:
https://doaj.org/article/ba2843a06c55451ab954b258992258ee
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34221 (2012)
The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of xenotropic murine leukaemia virus-related virus (XMRV) Envelope. No reactivity was found in
Externí odkaz:
https://doaj.org/article/58d598ba54644b0a97f857d5b2ffc165
Autor:
Jyotsna Batra, Felicity Lose, Tracy O'Mara, Louise Marquart, Carson Stephens, Kimberly Alexander, Srilakshmi Srinivasan, Rosalind A Eeles, Douglas F Easton, Ali Amin Al Olama, Zsofia Kote-Jarai, Michelle Guy, Kenneth Muir, Artitaya Lophatananon, Aneela A Rahman, David E Neal, Freddie C Hamdy, Jenny L Donovan, Suzanne Chambers, Robert A Gardiner, Joanne Aitken, John Yaxley, Mary-Anne Kedda, Judith A Clements, Amanda B Spurdle
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26527 (2011)
BackgroundKallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease.Obje
Externí odkaz:
https://doaj.org/article/e5eabb200e4343a1a2ae91e654fe29f2