Zobrazeno 1 - 10
of 182
pro vyhledávání: '"David E Lee"'
Autor:
Meng Zhao, Niels Banhos Danneskiold-Samsøe, Livia Ulicna, Quennie Nguyen, Laetitia Voilquin, David E Lee, James P White, Zewen Jiang, Nickeisha Cuthbert, Shrika Paramasivam, Ewa Bielczyk-Maczynska, Capucine Van Rechem, Katrin J Svensson
Publikováno v:
eLife, Vol 11 (2022)
The secreted protein isthmin-1 (Ism1) mitigates diabetes by increasing adipocyte and skeletal muscle glucose uptake by activating the PI3K-Akt pathway. However, while both Ism1 and insulin converge on these common targets, Ism1 has distinct cellular
Externí odkaz:
https://doaj.org/article/a676e29254204708a042c755a7058675
Autor:
Mohammed S Aiyegbo, Gopal Sapparapu, Benjamin W Spiller, Ilyas M Eli, Dewight R Williams, Robert Kim, David E Lee, Tong Liu, Sheng Li, Virgil L Woods, David P Nannemann, Jens Meiler, Phoebe L Stewart, James E Crowe
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61101 (2013)
Several live attenuated rotavirus (RV) vaccines have been licensed, but the mechanisms of protective immunity are still poorly understood. The most frequent human B cell response is directed to the internal protein VP6 on the surface of double-layere
Externí odkaz:
https://doaj.org/article/d90e29a9134149ab94b8e00efa12fec7
Autor:
Adrianna P P Zhang, Zachary A Bornholdt, Tong Liu, Dafna M Abelson, David E Lee, Sheng Li, Virgil L Woods, Erica Ollmann Saphire
Publikováno v:
PLoS Pathogens, Vol 8, Iss 2, p e1002550 (2012)
Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are characterized by early suppression of the host innate immune system. One of the proteins likely responsible for this effect is VP24. VP24 is known to antagonize int
Externí odkaz:
https://doaj.org/article/21713f99bec6488da2b38879486b180f
Autor:
Akshay Bareja, David E. Lee, Tricia Ho, Greg Waitt, Lauren H. McKay, Sarah A. Hannou, Melissa C. Orenduff, Kristen M. McGreevy, Alexandra Binder, Calen P. Ryan, Erik J. Soderblom, Daniel W. Belsky, Luigi Ferrucci, Jayanta Kumar Das, Nirad Banskota, Virginia B. Kraus, Janet L. Huebner, William E. Kraus, Kim M. Huffman, Gurpreet S. Baht, Steve Horvath, Robert J. Parmer, Lindsey A. Miles, James P. White
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113881- (2024)
Summary: An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilize
Externí odkaz:
https://doaj.org/article/427aacba1e9c45278727a51ef1f744a6
Autor:
Tyrone A. Washington, Wesley S. Haynie, Eleanor R. Schrems, Richard A. Perry, Jr., Lemuel A. Brown, Breanna M. Williams, Megan E. Rosa-Caldwell, David E. Lee, Jacob L. Brown
Publikováno v:
Sports Medicine and Health Science, Vol 4, Iss 3, Pp 198-208 (2022)
The ability of skeletal muscle to regenerate from injury is crucial for locomotion, metabolic health, and quality of life. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1A) is a transcriptional coactivator required for mitochondri
Externí odkaz:
https://doaj.org/article/dbef22a1cf4f4ed99f07d4477019e67f
Autor:
Seongkyun Lim, David E. Lee, Francielly Morena da Silva, Pieter J. Koopmans, Ivan J. Vechetti, Ferdinand von Walden, Nicholas P. Greene, Kevin A. Murach
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C1101-C1109
MicroRNAs (miRs) control stem cell biology and fate. Ubiquitously expressed and conserved miR-16 was the first miR implicated in tumorigenesis. miR-16 is low in muscle during developmental hypertrophy and regeneration. It is enriched in proliferating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c635bb5d3a8df2bb316fe4a5c50136b1
https://doi.org/10.1152/ajpcell.00071.2023
https://doi.org/10.1152/ajpcell.00071.2023
Autor:
Tyrone A. Washington, Eleanor R. Schrems, Wesley S. Haynie, Megan E. Rosa‐Caldwell, Jacob L. Brown, Landen Saling, Seongkyun Lim, Richard A. Perry, Lemuel A. Brown, David E. Lee, Nicholas P. Greene
Publikováno v:
Cell Biochemistry and Function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de9218be45c1ec5f32784042d8b8bd64
https://doi.org/10.1002/cbf.3797
https://doi.org/10.1002/cbf.3797
Autor:
Seongkyun Lim, J. William Deaver, Megan E. Rosa-Caldwell, David E. Lee, Francielly Morena da Silva, Ana Regina Cabrera, Eleanor R. Schrems, Landen W. Saling, Tyrone A. Washington, James D. Fluckey, Nicholas P. Greene
Publikováno v:
Am J Physiol Endocrinol Metab
microRNAs (miRs) are linked to various human diseases including type 2 diabetes mellitus (T2DM) and emerging evidence suggests that miRs may serve as potential therapeutic targets. Lower miR-16 content is consistent across different models of T2DM; h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462f166e516982ef1a7a6e2b13909808
https://doi.org/10.1152/ajpendo.00333.2021
https://doi.org/10.1152/ajpendo.00333.2021
Autor:
Ishan Barman, Narasimhan Rajaram, Alan J. Tackett, Stephanie D. Byrum, Charles M. Quick, Allen J. Gies, Nathan L. Avaritt, David E. Lee, Jesse D. Ivers, Paola Monterroso Diaz, Piyush Raj, Joel Rodriguez Troncoso, Santosh Kumar Paidi
Cancer immunotherapy provides durable clinical benefit in only a small fraction of patients, and identifying these patients is difficult due to a lack of reliable biomarkers for prediction and evaluation of treatment response. Here, we demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624098e667551aa0c755db084de732d1
https://doi.org/10.1158/0008-5472.c.6513670
https://doi.org/10.1158/0008-5472.c.6513670
Autor:
Ishan Barman, Narasimhan Rajaram, Alan J. Tackett, Stephanie D. Byrum, Charles M. Quick, Allen J. Gies, Nathan L. Avaritt, David E. Lee, Jesse D. Ivers, Paola Monterroso Diaz, Piyush Raj, Joel Rodriguez Troncoso, Santosh Kumar Paidi
Supplementary figures S1 and S2 and supplementary tables ST1 and ST2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6ded52a84d28c4bcdcc53106ee3456
https://doi.org/10.1158/0008-5472.22430638
https://doi.org/10.1158/0008-5472.22430638