Zobrazeno 1 - 10
of 654
pro vyhledávání: '"David E Kleiner"'
Severe combined immunodeficiency: improved survival leading to detection of underlying liver disease
Autor:
Anusha Vittal, Nehna Abdul Majeed, Elizabeth Garabedian, Jamie Marko, David E Kleiner, Rob Sokolic, Fabio Candotti, Harry Malech, Theo Heller, Christopher Koh
Publikováno v:
BMC Gastroenterology, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background Adenosine deaminase deficiency (ADA) is an autosomal recessive disorder leading to severe combined immunodeficiency (SCID). It is characterized patho-physiologically by intracellular accumulation of toxic products affecting lympho
Externí odkaz:
https://doaj.org/article/256b0a5a135547408f0e2ed934e6b8d6
Autor:
David E Kleiner, Tim F Greten, Cecilia Monge, Seth M Steinberg, Changqing Xie, Yuta Myojin, Kelley Coffman, Bradford J Wood, Bernadette Redd, Donna M Hrones, Elliott B Levy
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/b82a12bf11294d4aaeea198c2b7d15c9
Autor:
Stephen M Hewitt, David E Kleiner, Tim F Greten, William D Figg, Cecilia Monge, Seth M Steinberg, Maggie Cam, Benjamin Ruf, Austin G Duffy, Jonathan M Hernandez, Changqing Xie, Yuta Myojin, Kelley Coffman, Donna Mabry Hrones, Sophie Wang, Bradford J Wood, Elliot B Levy, Israa Juburi, Bernadette Redd, Philip Homan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Oncolytic immunotherapy represents a unique therapeutic platform for the treatment of cancer. Here, we evaluated the safety and efficacy of the combination of pexastimogene devacirepvec (PexaVec) plus durvalumab (anti-programmed death liga
Externí odkaz:
https://doaj.org/article/7d02b8ba4ef24ff8856cf44022b698f1
Autor:
Tinsay A Woreta, Mark L Van Natta, Mariana Lazo, Arunkumar Krishnan, Brent A Neuschwander-Tetri, Rohit Loomba, Anna Mae Diehl, Manal F Abdelmalek, Naga Chalasani, Samer Gawrieh, Srinivasan Dasarathy, Raj Vuppalanchi, Mohammad S Siddiqui, Kris V Kowdley, Arthur McCullough, Norah A Terrault, Cynthia Behling, David E Kleiner, Mark Fishbein, Paula Hertel, Laura A Wilson, Emily P Mitchell, Laura A Miriel, Jeanne M Clark, James Tonascia, Arun J Sanyal, NASH Clinical Research Network
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266859 (2022)
Background and aimsManagement of patients with NASH who are at elevated risk of progressing to complications of cirrhosis (at-risk NASH) would be enhanced by an accurate, noninvasive diagnostic test. The new FAST™ score, a combination of FibroScan
Externí odkaz:
https://doaj.org/article/1833c874d5f54e2e95c2ca91c5a16de6
Autor:
Baiyu Yang, Fatma M Shebl, Lawrence R Sternberg, Andrew C Warner, David E Kleiner, Daniel C Edelman, Allison Gomez, Casey L Dagnall, Belynda D Hicks, Sean F Altekruse, Brenda Y Hernandez, Charles F Lynch, Paul S Meltzer, Katherine A McGlynn
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166828 (2016)
BACKGROUND:Telomere shortening is an important molecular event in hepatocellular carcinoma (HCC) initiation; however, its role in HCC progression and prognosis is less clear. Our study aimed to examine the association of telomere length with survival
Externí odkaz:
https://doaj.org/article/6c1ea338eee6481a9435e3a410589de3
Autor:
Oriel Nissim, Marta Melis, Giacomo Diaz, David E Kleiner, Ashley Tice, Giovanni Fantola, Fausto Zamboni, Lopa Mishra, Patrizia Farci
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49611 (2012)
The liver has inherent regenerative capacity via mitotic division of mature hepatocytes or, when the hepatic loss is massive or hepatocyte proliferation is impaired, through activation of hepatic stem/progenitor cells (HSPC). The dramatic clinical co
Externí odkaz:
https://doaj.org/article/55c06d66e61f42be9a823cd947e780cf
Autor:
Rodrigo T Calado, Joshua A Regal, David E Kleiner, David S Schrump, Nathan R Peterson, Veronica Pons, Stephen J Chanock, Peter M Lansdorp, Neal S Young
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7926 (2009)
Telomerase is an enzyme specialized in maintaining telomere lengths in highly proliferative cells. Loss-of-function mutations cause critical telomere shortening and are associated with the bone marrow failure syndromes dyskeratosis congenita and apla
Externí odkaz:
https://doaj.org/article/cc31231c36fe46f8a65e5db5542ce313
Autor:
David E Greenberg, Li Ding, Adrian M Zelazny, Frida Stock, Alexandra Wong, Victoria L Anderson, Georgina Miller, David E Kleiner, Allan R Tenorio, Lauren Brinster, David W Dorward, Patrick R Murray, Steven M Holland
Publikováno v:
PLoS Pathogens, Vol 2, Iss 4, p e28 (2006)
Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. We ident
Externí odkaz:
https://doaj.org/article/0af7170f334c49aabd16db915ef569d8
Autor:
Alexander H. Yang, Mai Ai Thanda Han, Niharika Samala, Bisharah S. Rizvi, Rachel Marchalik, Ohad Etzion, Elizabeth C. Wright, Ruchi Patel, Vinshi Khan, Devika Kapuria, Vikramaditya Samala Venkat, David E. Kleiner, Christopher Koh, Jennifer A. Kanakry, Christopher G. Kanakry, Steven Pavletic, Kirsten M. Williams, Theo Heller
Publikováno v:
Hepatology Communications, Vol 6, Iss 8, Pp 2210-2220 (2022)
Abstract Hepatic graft‐versus‐host disease (HGVHD) contributes significantly to morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Clinical findings and liver biomarkers are neither sensitive nor specific. The relations
Externí odkaz:
https://doaj.org/article/7cd1c5d87ffc4d649b0437a235d0fef1
Autor:
Aviya Lanis, Rita Volochayev, David E. Kleiner, Anusha Vittal, Theo Heller, Lisa G. Rider, Susan Shenoi
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 20, Iss 1, Pp 1-5 (2022)
Abstract Background We present two cases of Nodular Regenerative Hyperplasia (NRH) associated with Juvenile Dermatomyositis (JDM). Case Presentation Case 1: A nine-year-old Caucasian male with refractory JDM and anti-NXP2 autoantibodies was diagnosed
Externí odkaz:
https://doaj.org/article/4d53fb72fa574925b7ee6cdb37432186