Zobrazeno 1 - 10 of 14 pro vyhledávání: '"David E Heckerman"'
1
Akademický článek
Increased breadth and depth of cytotoxic T lymphocytes responses against HIV-1-B Nef by inclusion of epitope variant sequences.
Autor: Morgane Rolland, Nicole Frahm, David C Nickle, Nebojsa Jojic, Wenjie Deng, Todd M Allen, Christian Brander, David E Heckerman, James I Mullins
Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17969 (2011)
Different vaccine approaches cope with HIV-1 diversity, ranging from centralized(1-4) to variability-encompassing(5-7) antigens. For all these strategies, a concern remains: how does HIV-1 diversity impact epitope recognition by the immune system? We
Externí odkaz: https://doaj.org/article/eddc39bc907f46f1aa5e2ad060ea48a6
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2
Akademický článek
Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
Autor: Morgane Rolland, Jonathan M Carlson, Siriphan Manocheewa, J Victor Swain, Erinn Lanxon-Cookson, Wenjie Deng, Christine M Rousseau, Dana N Raugi, Gerald H Learn, Brandon S Maust, Hoosen Coovadia, Thumbi Ndung'u, Philip J R Goulder, Bruce D Walker, Christian Brander, David E Heckerman, James I Mullins
Publikováno v: PLoS ONE, Vol 5, Iss 9 (2010)
Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (C
Externí odkaz: https://doaj.org/article/f4df0c7bf2524d97bd249e82a543bae6
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4
P16-41. Evidence for in vivo immune selection pressure exerted by HLA class I restricted CTL responses to anti-sense encoded HIV sequences
Autor: Mark A. Brockman, Christoph Berger, C Kadie, Richard Harrigan, Zabrina L. Brumme, Jonathan M. Carlson, LM Henry, Chanson J. Brumme, Christian Brander, K Hartman, David E. Heckerman
Publikováno v: Retrovirology
Retrovirology, Vol 6, Iss Suppl 3, p P270 (2009)
Europe PubMed Central
Background Past studies have suggested that certain portions of the integrated HIV-1 proviral genome can be transcribed in the anti-sense direction, resulting in novel viral protein products that may provide alternative targets for the host anti-vira
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3458c32901d996285f3bc1cda175b86e
https://doi.org/10.1186/1742-4690-6-s3-p270
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6
Leveraging Hierarchical Population Structure in Discrete Association Studies
Autor: Simon Mallal, Jonathan M. Carlson, Carl M. Kadie, David E. Heckerman
Publikováno v: PLoS ONE
PLoS ONE, Vol 2, Iss 7, p e591 (2007)
Population structure can confound the identification of correlations in biological data. Such confounding has been recognized in multiple biological disciplines, resulting in a disparate collection of proposed solutions. We examine several methods th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a2bd5e0008c4eaf14365741e3ab2c4
http://europepmc.org/articles/PMC1899226
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10
Conference
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