Zobrazeno 1 - 10
of 156
pro vyhledávání: '"David E Harrison"'
Autor:
Sher Bahadur Poudel, Ryan R. Ruff, Gozde Yildirim, Richard A. Miller, David E. Harrison, Randy Strong, Thorsten Kirsch, Shoshana Yakar
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and as one ages, various joint tissues undergo gradual c
Externí odkaz:
https://doaj.org/article/d256ca38541c4e61b75a42aa0e812485
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114324 (2014)
While rapamycin treatment has been reported to have a putatively negative effect on glucose homeostasis in mammals, it has not been tested in polygenic models of type 2 diabetes. One such mouse model, NONcNZO10/LtJ, was treated chronically with rapam
Externí odkaz:
https://doaj.org/article/93aef0a36d954748a96ff3aaf8135690
Autor:
Robert Pazdro, David E Harrison
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61235 (2013)
Adipose tissue-derived stromal cells (ADSCs) are of interest for regenerative medicine as they are isolated easily and can differentiate into multiple cell lineages. Studies of their in vitro proliferation, survival, and differentiation are common; h
Externí odkaz:
https://doaj.org/article/5538c011ba2a4e5f9d9446244991aaad
Autor:
Eric Y Zhang, Qiang Xiong, Lei Ye, Piradeep Suntharalingam, Xiaohong Wang, C Michael Astle, Jianyi Zhang, David E Harrison
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31099 (2012)
Debate surrounds the question of whether the heart is a post-mitotic organ in part due to the lack of an in vivo model in which myocytes are able to actively regenerate. The current study describes the first such mouse model--a fetal myocardial envir
Externí odkaz:
https://doaj.org/article/4c7991a31fea43f488e10ff100cd1d6c
Autor:
Lei Ye, Eric Yang Zhang, Qiang Xiong, Clinton M Astle, Pengyuan Zhang, Qinglu Li, Arthur H L From, David E Harrison, Jianyi Jay Zhang
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33407 (2012)
Both bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit(+) cells counts and ii. the stability of left ventricu
Externí odkaz:
https://doaj.org/article/7a0a00d383c54e4aa9cd67d277e8bbf8
Autor:
Richard A. Miller, David E. Harrison, David B. Allison, Molly Bogue, Lucas Debarba, Vivian Diaz, Elizabeth Fernandez, Andrzej Galecki, W. Timothy Garvey, Hashan Jayarathne, Navasuja Kumar, Martin A. Javors, Warren C. Ladiges, Francesca Macchiarini, James Nelson, Peter Reifsnyder, Nadia A. Rosenthal, Marianna Sadagurski, Adam B. Salmon, Daniel L. Smith Jr., Jessica M. Snyder, David B. Lombard, Randy Strong
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
Canagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular and kidney diseases. It also inhibits the sodium glucose transporter 2 by blocking renal reuptake and intestinal absorption of glucose. In the context of the m
Externí odkaz:
https://doaj.org/article/8346a43abd5742d2afbdcea95b0aa4d1
Autor:
Jessica M. Snyder, Kerriann M. Casey, Andrzej Galecki, David E. Harrison, Hashan Jayarathne, Navasuja Kumar, Francesca Macchiarini, Nadia Rosenthal, Marianna Sadagurski, Adam B. Salmon, Randy Strong, Richard A. Miller, Warren Ladiges
Publikováno v:
GeroScience. 45:385-397
Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% increase in the 90th percentile age when given to genetically heterogeneous male mice from 7 months of age, but does not increase lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815a84b77b6ad24dcfa81afeb6025f6c
https://doi.org/10.1007/s11357-022-00641-0
https://doi.org/10.1007/s11357-022-00641-0
Autor:
Gozde Yildirim, Edmara T. P. Bergamo, Sher Bahadur Poudel, Ryan R. Ruff, Manisha Dixit, Bin Hu, Dindo Q. Mijares, Lukasz Witek, Carolyn Chlebek, David E. Harrison, Randy Strong, Richard A. Miller, Warren Ladiges, Timothy G. Bromage, Clifford J. Rosen, Shoshana Yakar
Publikováno v:
GeroScience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4408faf88b9d7fa36c8318227aba7aa0
https://doi.org/10.1007/s11357-023-00803-8
https://doi.org/10.1007/s11357-023-00803-8
Autor:
Jake W. Willows, Morganne Robinson, Zahra Alshahal, Samantha K. Morrison, Gargi Mishra, Harrison Cyr, Magdalena Blaszkiewicz, Gilian Gunsch, Sabrina DiPietro, Emma Paradie, Benjamin Tero, Anne Harrington, Larisa Ryzhova, Lucy Liaw, Peter C. Reifsnyder, David E. Harrison, Kristy L. Townsend
Publikováno v:
Aging Cell
Cover legend: The cover image is based on the Research Article Age‐related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment by Jake W. Willows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85aa5dafb8023f319c0d3e98c135ca3
https://europepmc.org/articles/PMC10086519/
https://europepmc.org/articles/PMC10086519/
Autor:
Jake W. Willows, Morganne Robinson, Zahra Alshahal, Samantha K. Morrison, Gargi Mishra, Harrison Cyr, Magdalena Blaszkiewicz, Gilian Gunsch, Sabrina DiPietro, Emma Paradie, Benjamin Tero, Anne Harrington, Larisa Ryzhova, Lucy Liaw, Peter C. Reifsnyder, David E. Harrison, Kristy L. Townsend
Publikováno v:
Aging Cell. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c65663e5369a55bf3de09f647aca4a7d
https://doi.org/10.1111/acel.13784
https://doi.org/10.1111/acel.13784