Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David E Frankhouser"'
Autor:
Bin Zhang, Le Xuan Truong Nguyen, Dandan Zhao, David E. Frankhouser, Huafeng Wang, Dinh Hoa Hoang, Junjing Qiao, Christina Abundis, Matthew Brehove, Yu-Lin Su, Yuxin Feng, Anthony Stein, Lucy Ghoda, Adrianne Dorrance, Danilo Perrotti, Zhen Chen, Anjia Han, Flavia Pichiorri, Jie Jin, Tijana Jovanovic-Talisman, Michael A. Caligiuri, Calvin J. Kuo, Akihiko Yoshimura, Ling Li, Russell C. Rockne, Marcin Kortylewski, Yi Zheng, Nadia Carlesso, Ya-Huei Kuo, Guido Marcucci
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Background During acute myeloid leukemia (AML) growth, the bone marrow (BM) niche acquires significant vascular changes that can be offset by therapeutic blast cytoreduction. The molecular mechanisms of this vascular plasticity remain to be
Externí odkaz:
https://doaj.org/article/52f9905cc5f14aa08a70fe465bcdd2b1
Autor:
Jackson A. Killian, Taha M. Topiwala, Alex R. Pelletier, David E. Frankhouser, Pearlly S. Yan, Ralf Bundschuh
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background Gene fusions often occur in cancer cells and in some cases are the main driver of oncogenesis. Correct identification of oncogenic gene fusions thus has implications for targeted cancer therapy. Recognition of this potential has l
Externí odkaz:
https://doaj.org/article/51f7aa11f5a0449da052784b5c99f0c2
Autor:
Guido Marcucci, Ya-Huei Kuo, Nadia Carlesso, Stephen Forman, Leo D. Wang, Zheng Liu, Yate-Ching Yuan, Xiwei Wu, Davide Maestrini, Herman Wu, Ayelet Marom, Lianjun Zhang, Emily Carnahan, Guerry Cook, Wei-Kai Hua, Denis O'Meally, David E. Frankhouser, Jing Qi, Sergio Branciamore, Russell C. Rockne
Temporal dynamics of gene expression inform cellular and molecular perturbations associated with disease development and evolution. Given the complexity of high-dimensional temporal genomic data, an analytic framework guided by a robust theory is nee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9434819c6d2b6341baa87eb37c88ac11
https://doi.org/10.1158/0008-5472.c.6512287
https://doi.org/10.1158/0008-5472.c.6512287
Autor:
Guido Marcucci, Ya-Huei Kuo, Nadia Carlesso, Stephen Forman, Leo D. Wang, Zheng Liu, Yate-Ching Yuan, Xiwei Wu, Davide Maestrini, Herman Wu, Ayelet Marom, Lianjun Zhang, Emily Carnahan, Guerry Cook, Wei-Kai Hua, Denis O'Meally, David E. Frankhouser, Jing Qi, Sergio Branciamore, Russell C. Rockne
Table S1. Differentially expressed genes for c_1 vs c_1^* Table S2. Differentially expressed genes for c_2 vs c_1^* Table S3. Differentially expressed genes for c_3 vs c_1^* Table S4. Differentially expressed genes for c_2 vs c_1 Table S5. Differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac7593ac16783c4942fb5829245ed82
https://doi.org/10.1158/0008-5472.22426285.v1
https://doi.org/10.1158/0008-5472.22426285.v1
Autor:
Guido Marcucci, Ya-Huei Kuo, Nadia Carlesso, Stephen Forman, Leo D. Wang, Zheng Liu, Yate-Ching Yuan, Xiwei Wu, Davide Maestrini, Herman Wu, Ayelet Marom, Lianjun Zhang, Emily Carnahan, Guerry Cook, Wei-Kai Hua, Denis O'Meally, David E. Frankhouser, Jing Qi, Sergio Branciamore, Russell C. Rockne
Figure S1. Details of animal model and fusion gene CM, Figure S2. Ex vivo flow cytometry analysis of bone marrow, Figure S3. Details of principal component analysis, Figure S4. Comparison of state-space construction with different dimension reduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e86b8148bcb011ba66d9887b73a42d
https://doi.org/10.1158/0008-5472.22426288.v1
https://doi.org/10.1158/0008-5472.22426288.v1
Autor:
Guido Marcucci, Ya-Huei Kuo, Nadia Carlesso, Stephen Forman, Leo D. Wang, Zheng Liu, Yate-Ching Yuan, Xiwei Wu, Davide Maestrini, Herman Wu, Ayelet Marom, Lianjun Zhang, Emily Carnahan, Guerry Cook, Wei-Kai Hua, Denis O'Meally, David E. Frankhouser, Jing Qi, Sergio Branciamore, Russell C. Rockne
In this supplement we provide additional data and methods to support our results. In particular, we show: details of our mouse model of AML; demonstrate the robustness of our state-space construction to normalization methods and gene selection criter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcd275d8913253b4e0918e14ae2f0c5
https://doi.org/10.1158/0008-5472.22426282.v1
https://doi.org/10.1158/0008-5472.22426282.v1
Autor:
Karl W. Kroll, Nima E. Mokaram, Alexander R. Pelletier, David E. Frankhouser, Maximillian S. Westphal, Paige A. Stump, Cameron L. Stump, Ralf Bundschuh, James S. Blachly, Pearlly Yan
Publikováno v:
Cancer Informatics, Vol 2014, Iss Suppl. 3, Pp 7-14 (2014)
Externí odkaz:
https://doaj.org/article/b76bfd8b0fc346529c289b9067bdff04
Autor:
David E. Frankhouser, Denis O’Meally, Sergio Branciamore, Lisa Uechi, Lianjun Zhang, Ying-Chieh Chen, Man Li, Hanjun Qin, Xiwei Wu, Nadia Carlesso, Guido Marcucci, Russell C. Rockne, Ya-Huei Kuo
Publikováno v:
Science Advances. 8
MicroRNAs (miRNAs) have been shown to hold prognostic value in acute myeloid leukemia (AML); however, the temporal dynamics of miRNA expression in AML are poorly understood. Using serial samples from a mouse model of AML to generate time-series miRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c2e6c96923327e64b58f7324b9d4fd
https://doi.org/10.1126/sciadv.abj1664
https://doi.org/10.1126/sciadv.abj1664
Autor:
Martha A. Belury, Michael G. Sovic, Lisa D. Yee, Ralf Bundschuh, Sarah A. Steck, David E Frankhouser, Pearlly S. Yan
BackgroundOmega-3 or n-3 polyunsaturated fatty acids (PUFAs) are widely studied for health benefits based on potential anti-inflammatory effects. However, the factors involved in mediating the anti-inflammatory responses to n-3 PUFAs are not fully un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4957e29b6257d83e102b09c880ec0aaf
https://doi.org/10.1101/2020.10.09.20209726
https://doi.org/10.1101/2020.10.09.20209726
Autor:
Ling Li, Ya-Huei Kuo, Bin Amber Zhang, Le Xuan Truong Nguyen, Guido Marcucci, Shanshan Suo, Dandan Zhao, Huafeng Wang, Lucy Ghoda, Chen Liang, Junjing Qiao, David E Frankhouser, Russell C. Rockne, Yasmin Elhajmoussa, Mark Boldin
Publikováno v:
Blood. 136:4-4
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm resulting from the BCR-ABL1 fusion gene that encodes a constitutively activated tyrosine kinase (TK). Although TK inhibitors (TKIs) induce disease remission and prolonged survival in CML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f916748cf5bfc3b5e3ca7a4f7ddf977
https://doi.org/10.1182/blood-2020-143202
https://doi.org/10.1182/blood-2020-143202