Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David E Durrant"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45243 (2012)
Insulin resistance impairs nitric oxide (NO) bioavailability and obesity promotes a state of chronic inflammation and damages the vascular endothelium. Phosphodiesterase-5 inhibitors restore NO signaling and may reduce circulating inflammatory marker
Externí odkaz:
https://doaj.org/article/046a3a5f3a7e4109b786d51d16a18209
Autor:
Sarath P. D. Senadeera, Dongdong Wang, Chang-Kwon Kim, Emily A. Smith, David E. Durrant, Patrick A. Alexander, Karen L. Wendt, Andrew G. Stephen, Deborah K. Morrison, Robert H. Cichewicz, Curtis J. Henrich, John A. Beutler
Publikováno v:
Journal of Natural Products. 85:1603-1616
Autor:
Curtis J. Henrich, Emily A. Smith, Carole A. Bewley, Chang-Kwon Kim, Kirk R. Gustafson, Deborah K. Morrison, Dongdong Wang, David E. Durrant, Richard W. Fuller, Heidi R. Bokesch
Publikováno v:
J Nat Prod
Two new cyclic depsipeptides named swinhopeptolides A (1) and B (2), have been isolated from the marine sponge Theonella swinhoei cf. verrucosa, collected from Papua New Guinea. They each contain 11 diverse amino acid resudues and 13-carbon polyketid
Autor:
Andrew G. Stephen, Nirmala Sharma, Emily A. Smith, Curtis J. Henrich, Patrick Alexander, Ekaterina I. Goncharova, Deborah K. Morrison, David E. Durrant
Publikováno v:
Mol Cancer Ther
Activating mutations in RAS are found in approximately 30% of human cancers, resulting in the delivery of a persistent signal to critical downstream effectors that drive tumorigenesis. RAS-driven malignancies respond poorly to conventional cancer tre
Autor:
David E. Durrant, Deborah K. Morrison
Publikováno v:
British Journal of Cancer
The Raf protein kinases are key intermediates in cellular signal transduction, functioning as direct effectors of the Ras GTPases and as the initiating kinases in the ERK cascade. In human cancer, Raf activity is frequently dysregulated due to mutati
Autor:
Daniel A. Ritt, Deborah K. Morrison, Yong Zhou, David E. Durrant, Elizabeth M. Terrell, Dominic Esposito, Russell Spencer-Smith, Robert L. Kortum, John F. Hancock, Erin Sheffels, Nancy E. Sealover
Publikováno v:
Molecular cell. 76(6)
The Ras GTPases are frequently mutated in human cancer, and, although the Raf kinases are essential effectors of Ras signaling, the tumorigenic properties of specific Ras-Raf complexes are not well characterized. Here, we examine the ability of indiv
Autor:
Samya Dyer, David E. Durrant, Paul Dent, Anindita Das, Rakesh C. Kukreja, Seyedmehrad Tavallai
Publikováno v:
Molecular Pharmacology. 88:512-523
Pancreatic cancer has the lowest 5-year survival rate of all major cancers despite decades of effort to design and implement novel, more effective treatment options. In this study, we tested whether the dual phosphoinositide 3-kinase/mechanistic targ
Autor:
Andrew G. Stephen, Ming Zhou, Suzanne I. Specht, Matthew Holderfield, Deborah K. Morrison, David E. Durrant, Maria Teresa Abreu-Blanco, Lakshman Bindu, Daniel A. Ritt
Publikováno v:
Molecular cell. 64(5)
Ras pathway signaling plays a critical role in cell growth control and is often upregulated in human cancer. The Raf kinases selectively interact with GTP-bound Ras and are important effectors of Ras signaling, functioning as the initiating kinases i
Publikováno v:
Circulation. 130
Background: Cardiotoxicity is a major clinical limitation with doxorubicin (DOX). Also, the PI3K/Akt survival pathway is one of the most commonly mutated pathways in cancer. Therefore, the combination of kinase inhibitors and chemotherapy, such as DO
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
RAF kinases are essential for RAS protein signalling but how RAS binding regulates dimerization and activation of RAF has remained unclear. Here, the authors report cryoEM structures that provide mechanistic insights into the RAS-mediated monomer-to-
Externí odkaz:
https://doaj.org/article/34e7836b1f4c4780b3bb919337e7db0b