The gene-immune-behavioral pathway: Gamma-interferon (IFN-γ) simultaneously coordinates susceptibility to infectious disease and harm avoidance behaviors

Autor: David E. Comings, James P. MacMurray, Valerio Napolioni

Publikováno v: Brain, Behavior, and Immunity. 35:169-175

Cytokine gene variants are known to influence both infectious disease susceptibility and harm-avoidant behaviors, suggesting that these risk variants may be pleiotropically linked to instinctual disease-avoidant traits. The gamma-interferon (IFNG) +8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117e239a98cbec81c494dbc319f024db
https://doi.org/10.1016/j.bbi.2013.09.012

Generational Association Studies of Dopaminergic Genes in Reward Deficiency Syndrome (RDS) Subjects: Selecting Appropriate Phenotypes for Reward Dependence Behaviors

Autor: Caroline Davis, John Giordano, John Schoolfield, Joel F. Lubar, John Femino, Frank Fornari, Eric R. Braverman, Abdalla Bowirrat, Thomas J H Chen, John A. Bailey, Kenneth Blum, Marlene Oscar-Berman, David E. Comings, Bernard W. Downs, Nancy White, Tomás Palomo, Siobhan Morse, Mallory Kerner, Margaret A. Madigan, Debmalya Barh, Amanda L C Chen, Jennifer Knopf, Judith O. Lubar, Roger L. Waite

Publikováno v: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 8, Iss 12, Pp 4425-4459 (2011)
International Journal of Environmental Research and Public Health; Volume 8; Issue 12; Pages: 4425-4459

Abnormal behaviors involving dopaminergic gene polymorphisms often reflect an insufficiency of usual feelings of satisfaction, or Reward Deficiency Syndrome (RDS). RDS results from a dysfunction in the “brain reward cascade,” a complex interactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2745a5651f15a126866296cbd7c58d
http://europepmc.org/articles/PMC3290972

Maternal age at the birth of the first child as an epistatic factor in polygenic disorders

Autor: David E. Comings, James P. MacMurray

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :1-6

The identification of the genes for complex, polygenic disorders has proven difficult. This is due to the small effect size of each gene and genetic heterogeneity. An additional important factor could be the presence of unidentified epistatic factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535a4867b7e76fa2ab521e4d74f7e6cb
https://doi.org/10.1002/ajmg.b.30026

Association of CCR5 Δ32 deletion with early death in multiple sclerosis

Autor: Radhika Gade-Andavolu, James P. MacMurray, Masoud Rostamkhani, Wallace W. Tourtellotte, Li S C Cheng, David E. Comings, Lawrence A. Cone

Publikováno v: Genetics in Medicine. 6:126-131

Purpose: The interaction between chemokines and their receptors is extremely important in controlling T cell migration into sites of CNS inflammation. Because trafficking of inflammatory T cells into the central nervous system (CNS) is a key player i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea8256c9e03845732cb69990c0215cb
https://doi.org/10.1097/01.gim.0000127274.45301.54

PhenylethanolamineN-MethyltransferaseG-148AGenetic Variant and Weight Loss in Obese Women

Autor: Russell J. Giese, James P. MacMurry, Jennifer Walker, Warren R. Peters, David E. Comings

Publikováno v: Obesity Research. 11:415-419

PETERS, WARREN R., JAMES P. MACMURRY,JENNIFER WALKER, RUSSELL J. GIESE, JR., ANDDAVID E. COMINGS. Phenylethanolamine N-methyl-transferase G-148Agenetic variant and weight loss in obesewomen. Obes Res. 2003;11:415–419.Objective: To understand the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1d3ebde69d8fc80e3cc5dc52ea1c45
https://doi.org/10.1038/oby.2003.56