Zobrazeno 1 - 10
of 387
pro vyhledávání: '"David E Clapham"'
Autor:
Alexandria N Miller, Patrick R Houlihan, Ella Matamala, Deny Cabezas-Bratesco, Gi Young Lee, Ben Cristofori-Armstrong, Tanya L Dilan, Silvia Sanchez-Martinez, Doreen Matthies, Rui Yan, Zhiheng Yu, Dejian Ren, Sebastian E Brauchi, David E Clapham
Publikováno v:
eLife, Vol 12 (2023)
The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic pathway, and Golgi apparatus. Some reports have led to annotation of both Or
Externí odkaz:
https://doaj.org/article/7aea50eabcf9434b9dd126c619c9efbc
Autor:
Chandima Bulumulla, Andrew T Krasley, Ben Cristofori-Armstrong, William C Valinsky, Deepika Walpita, David Ackerman, David E Clapham, Abraham G Beyene
Publikováno v:
eLife, Vol 11 (2022)
Chemical neurotransmission constitutes one of the fundamental modalities of communication between neurons. Monitoring release of these chemicals has traditionally been difficult to carry out at spatial and temporal scales relevant to neuron function.
Externí odkaz:
https://doaj.org/article/4a2fa60da74749aca50297935f2eef29
Publikováno v:
eLife, Vol 7 (2018)
We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membra
Externí odkaz:
https://doaj.org/article/4fba5978103d4fb8a50805315ff8f96b
Publikováno v:
eLife, Vol 7 (2018)
Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a clear understanding of polycystin proteins’ functions as ion channels. Thi
Externí odkaz:
https://doaj.org/article/1316725f3ce14c489a7b1855b8cfe8a7
Autor:
Jean-Ju Chung, Kiyoshi Miki, Doory Kim, Sang-Hee Shim, Huanan F Shi, Jae Yeon Hwang, Xinjiang Cai, Yusuf Iseri, Xiaowei Zhuang, David E Clapham
Publikováno v:
eLife, Vol 6 (2017)
We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe mal
Externí odkaz:
https://doaj.org/article/8a2945ab64c74cf1abc30e982df1d112
Publikováno v:
eLife, Vol 5 (2016)
Native PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces. Here we investigate the mechanism for the channel's unusual regulation by external calcium, and rationalize this behavior to its specialized function.
Externí odkaz:
https://doaj.org/article/c3b438efcb634f2c8ee9aafcb8a9ac43
Publikováno v:
eLife, Vol 4 (2015)
The beating of motile cilia generates fluid flow over epithelia in brain ventricles, airways, and Fallopian tubes. Here, we patch clamp single motile cilia of mammalian ependymal cells and examine their potential function as a calcium signaling compa
Externí odkaz:
https://doaj.org/article/1ad6ee3a971b434aaa6f73aa05ddcd2a
Publikováno v:
eLife, Vol 3 (2014)
Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for cation/proton antiporters resp
Externí odkaz:
https://doaj.org/article/557cb0f0b2514e758c78e6d74cd1765b
Autor:
David E Clapham
Publikováno v:
eLife, Vol 2 (2013)
Massive endocytosis is initiated by a series of steps that involve a sudden influx of calcium ions, changes in mitochondria, and modification of surface proteins by lipids. A better understanding of this process could lead to new approaches to reduci
Externí odkaz:
https://doaj.org/article/807c68be2204428794bb5f9355899741
Autor:
David E Clapham
Publikováno v:
eLife, Vol 2 (2013)
Human sperm cells rely on an unusual type of potassium ion channel.
Externí odkaz:
https://doaj.org/article/f4f5bc53005a486180182df60863cc84