Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David E Almanzar"'
BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis
Autor:
Erik Toraason, Alina Salagean, David E Almanzar, Jordan E Brown, Colette M Richter, Nicole A Kurhanewicz, Ofer Rog, Diana E Libuda
Publikováno v:
eLife, Vol 13 (2024)
The preservation of genome integrity during sperm and egg development is vital for reproductive success. During meiosis, the tumor suppressor BRCA1/BRC-1 and structural maintenance of chromosomes 5/6 (SMC-5/6) complex genetically interact to promote
Externí odkaz:
https://doaj.org/article/5cc501e585fc4bf7b72400fd15e82b53
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101344- (2022)
Summary: Reciprocal exchanges between genetically identical sister chromatids (sister chromatid exchanges or SCEs) have been challenging to study. Here, we describe a protocol that utilizes a pulse/chase of the thymidine analog 5-ethyl-3′-deoxyurid
Externí odkaz:
https://doaj.org/article/73eb4b58d399473ab8ce966840328be0
The preservation of genome integrity during sperm and egg development is vital for reproductive success. During meiosis, the tumor suppressor BRCA1/BRC-1 and structural maintenance of chromosomes 5/6 (SMC-5/6) complex genetically interact to promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a485b18159ea28800fad196ae8c86a5b
https://doi.org/10.1101/2022.06.12.495837
https://doi.org/10.1101/2022.06.12.495837
Autor:
David E Almanzar, Spencer G Gordon, Chloe Bristow, Antonia Hamrick, Lexy von Diezmann, Hanwenheng Liu, Ofer Rog
Publikováno v:
Life Science Alliance. 6:e202301906
During meiosis, programmed double-strand DNA breaks are repaired to form exchanges between the parental chromosomes called crossovers. Chromosomes lacking a crossover fail to segregate accurately into the gametes, leading to aneuploidy. In addition t
Publikováno v:
Curr Biol
Sexual reproduction shuffles the parental genomes to generate new genetic combinations. To achieve that, the genome is subjected to numerous double-strand breaks, the repair of which involves two crucial decisions: repair pathway and repair template
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f6c15efcfef88bc1df79c99bdb65fc
https://europepmc.org/articles/PMC8051885/
https://europepmc.org/articles/PMC8051885/
Sexual reproduction shuffles the parental genomes to generate new genetic combinations. To achieve that, the genome is subjected to numerous double-strand breaks, the repair of which involves two crucial decisions: repair pathway and repair template.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8016f5f47359841ec4485e54f064dfcc
https://doi.org/10.1101/2020.07.22.216614
https://doi.org/10.1101/2020.07.22.216614