Zobrazeno 1 - 10
of 16
pro vyhledávání: '"David E, Paschon"'
Autor:
David E. Paschon, Stephanie Lussier, Tenzin Wangzor, Danny F. Xia, Patrick W. Li, Sarah J. Hinkley, Nicholas A. Scarlott, Stephen C. Lam, Adam J. Waite, Lynn N. Truong, Nimisha Gandhi, Bhakti N. Kadam, Deepak P. Patil, David A. Shivak, Gary K. Lee, Michael C. Holmes, Lei Zhang, Jeffrey C. Miller, Edward J. Rebar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Genome editing often requires cleavage within a narrow sequence window. Here the authors develop an expanded set of zinc finger nuclease architectures that increase the available configurations by a factor of 64 and can target almost every base at lo
Externí odkaz:
https://doaj.org/article/52399a6682884a7196ea64923e436811
Autor:
Tamara J. Laskowski, Yasmine Van Caeneghem, Rasoul Pourebrahim, Chao Ma, Zhenya Ni, Zita Garate, Ana M. Crane, Xuan Shirley Li, Wei Liao, Manuel Gonzalez-Garay, Jose Carlos Segovia, David E. Paschon, Edward J. Rebar, Michael C. Holmes, Dan Kaufman, Bart Vandekerckhove, Brian R. Davis
Publikováno v:
Stem Cell Reports, Vol 7, Iss 2, Pp 139-148 (2016)
Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disease caused by mutations in the gene encoding the WAS protein (WASp). Here, induced pluripotent stem cells (iPSCs) were derived from a WAS patient (WAS-iPSC) and the endogenous
Externí odkaz:
https://doaj.org/article/676abc2202b146eb97e086edfc92f229
Autor:
Ana M. Crane, Philipp Kramer, Jacquelin H. Bui, Wook Joon Chung, Xuan Shirley Li, Manuel L. Gonzalez-Garay, Finn Hawkins, Wei Liao, Daniela Mora, Sangbum Choi, Jianbin Wang, Helena C. Sun, David E. Paschon, Dmitry Y. Guschin, Philip D. Gregory, Darrell N. Kotton, Michael C. Holmes, Eric J. Sorscher, Brian R. Davis
Publikováno v:
Stem Cell Reports, Vol 4, Iss 4, Pp 569-577 (2015)
Recently developed reprogramming and genome editing technologies make possible the derivation of corrected patient-specific pluripotent stem cell sources—potentially useful for the development of new therapeutic approaches. Starting with skin fibro
Externí odkaz:
https://doaj.org/article/3bd18eafc9e34d40b5c4fab5ff9e7a11
Autor:
Laurie H. Sanders, Josée Laganière, Oliver Cooper, Sally K. Mak, B. Joseph Vu, Y. Anne Huang, David E. Paschon, Malini Vangipuram, Ramya Sundararajan, Fyodor D. Urnov, J. William Langston, Philip D. Gregory, H. Steve Zhang, J. Timothy Greenamyre, Ole Isacson, Birgitt Schüle
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 381-386 (2014)
Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress. Since mitoch
Externí odkaz:
https://doaj.org/article/d505d3408a924944819f08f5874cf168
Autor:
Bryan, Zeitler, Steven, Froelich, Kimberly, Marlen, David A, Shivak, Qi, Yu, Davis, Li, Jocelynn R, Pearl, Jeffrey C, Miller, Lei, Zhang, David E, Paschon, Sarah J, Hinkley, Irina, Ankoudinova, Stephen, Lam, Dmitry, Guschin, Lexi, Kopan, Jennifer M, Cherone, Hoang-Oanh B, Nguyen, Guijuan, Qiao, Yasaman, Ataei, Matthew C, Mendel, Rainier, Amora, Richard, Surosky, Josee, Laganiere, B Joseph, Vu, Anand, Narayanan, Yalda, Sedaghat, Karsten, Tillack, Christina, Thiede, Annette, Gärtner, Seung, Kwak, Jonathan, Bard, Ladislav, Mrzljak, Larry, Park, Taneli, Heikkinen, Kimmo K, Lehtimäki, Marie M, Svedberg, Jenny, Häggkvist, Lenke, Tari, Miklós, Tóth, Andrea, Varrone, Christer, Halldin, Andrea E, Kudwa, Sylvie, Ramboz, Michelle, Day, Jyothisri, Kondapalli, D James, Surmeier, Fyodor D, Urnov, Philip D, Gregory, Edward J, Rebar, Ignacio, Muñoz-Sanjuán, H Steve, Zhang
Publikováno v:
Nature medicine. 25(7)
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d3620bad8fe21aa64bd37ef53578561
https://pubmed.ncbi.nlm.nih.gov/31263285
https://pubmed.ncbi.nlm.nih.gov/31263285
Publikováno v:
Journal of Molecular Biology. 353:26-37
Many monomeric proteins can be split into two fragments, yet the two fragments can associate to make an active heterodimer. However, for most locations in a protein such a conversion is not feasible, presumably due to inefficient assembly or improper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c4d1ecc1834863348db74c6ac52ba4
https://doi.org/10.1016/j.jmb.2005.08.026
https://doi.org/10.1016/j.jmb.2005.08.026
Autor:
David E. Paschon, Marc Ostermeier
Publisher Summary This chapter discusses the construction of protein fragment complementation libraries using incremental truncation. Many proteins can have their peptide backbone cut by proteolytic or genetic means, yet the two fragments can associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfdc5cd560238a6a47f5a424b26ff2c7
https://doi.org/10.1016/s0076-6879(04)88010-8
https://doi.org/10.1016/s0076-6879(04)88010-8
Autor:
Miller, Jeffrey C1, Zhang, Lei1, Xia, Danny F1, Campo, John J1, Ankoudinova, Irina V1, Guschin, Dmitry Y1, Babiarz, Joshua E1, Meng, Xiangdong1, Hinkley, Sarah J1, Lam, Stephen C1, Paschon, David E1, Vincent, Anna I1, Dulay, Gladys P1, Barlow, Kyle A1, Shivak, David A1, Leung, Elo1, Kim, Jinwon D1, Amora, Rainier1, Urnov, Fyodor D1, Gregory, Philip D1
Publikováno v:
Nature Methods. May2015, Vol. 12 Issue 5, p465-471. 7p. 2 Diagrams, 1 Chart, 3 Graphs.
Publikováno v:
Suiform Soundings. Sep2016, Vol. 15 Issue 1, p93-138. 46p.
Autor:
Miller, Jeffrey C., Patil, Deepak P., Xia, Danny F., Paine, Charles B., Fauser, Friedrich, Richards, Hunter W., Shivak, David A., Bendaña, Yuri R., Hinkley, Sarah J., Scarlott, Nicholas A., Lam, Stephen C., Reik, Andreas, Zhou, Yuanyue, Paschon, David E., Li, Patrick, Wangzor, Tenzin, Lee, Gary, Zhang, Lei, Rebar, Edward J.
Publikováno v:
Nature Biotechnology; Aug2019, Vol. 37 Issue 8, p945-952, 8p, 2 Diagrams, 1 Chart, 1 Graph