Zobrazeno 1 - 10
of 301
pro vyhledávání: '"David E, Nelson"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Macrophages are tissue resident innate phagocytic cells that take on contrasting phenotypes, or polarization states, in response to the changing combination of microbial and cytokine signals at sites of infection. During the opening stages of an infe
Externí odkaz:
https://doaj.org/article/0655aa7062184591a6708bd2adb8ca02
Autor:
Brad Griesenauer, Yue Xing, Katherine R Fortney, Xiang Gao, Camila González-Beiras, David E Nelson, Jie Ren, Oriol Mitjà, Qunfeng Dong, Stanley M Spinola
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 12, p e0011009 (2022)
BackgroundIn yaws-endemic areas, two-thirds of exudative cutaneous ulcers (CU) are associated with Treponema pallidum subsp. pertenue (TP) and Haemophilus ducreyi (HD); one-third are classified as idiopathic ulcers (IU). A yaws eradication campaign o
Externí odkaz:
https://doaj.org/article/2f3e62e4f9194a1a9be1431389e0ff00
Autor:
J. Logan Bowling, Mary Catherine Skolfield, Wesley A. Riley, Andrew P. Nolin, Larissa C. Wolf, David E. Nelson
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-21 (2019)
Abstract Background The PINK1:Parkin pathway regulates the autophagic removal of damaged and dysfunctional mitochondria. While the response of this pathway to complete loss of ΔΨm, as caused by high concentrations of mitochondrial ionophores, has b
Externí odkaz:
https://doaj.org/article/f3c87354457249f4a03ec87c2c79cd5a
Autor:
Brad Griesenauer, Camila González-Beiras, Katherine R. Fortney, Huaiying Lin, Xiang Gao, Charmie Godornes, David E. Nelson, Barry P. Katz, Sheila A. Lukehart, Oriol Mitjà, Qunfeng Dong, Stanley M. Spinola
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Cutaneous ulcers (CU) affect approximately 100,000 children in the tropics each year. While two-thirds of CU are caused by Treponema pallidumpertenueHaemophilus ducreyi
Externí odkaz:
https://doaj.org/article/57274e2ae66843dd80189529eccc4c0f
Autor:
Sandra G. Morrison, Amanda M. Giebel, Evelyn Toh, Arkaprabha Banerjee, David E. Nelson, Richard P. Morrison
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Chlamydia spp. productively infect mucosal epithelial cells of multiple anatomical sites, including the conjunctiva, lungs, gastrointestinal (GI) tract, and urogenital tract. We, and others, previously established that chlamydial GI tropism
Externí odkaz:
https://doaj.org/article/db749f5c194844359773b2161f9ac76a
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228467 (2020)
Urethritis, or inflammation of the urethra, is one of the most common reasons men seek clinical care. Sexually transmitted pathogens including Neisseria gonorrhoeae are responsible for over half of the symptomatic urethritis cases in U.S. men. Recent
Externí odkaz:
https://doaj.org/article/a80304c2da4a476b8dd6808ee85794b9
Autor:
Aarthi Subramani, Prianca Griggs, Niah Frantzen, James Mendez, Jamila Tucker, Jada Murriel, Linda M Sircy, Grace E Millican, Erin E McClelland, Rebecca L Seipelt-Thiemann, David E Nelson
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0233818 (2020)
Macrophages serve as a first line of defense against infection with the facultative intracellular pathogen, Cryptococcus neoformans (Cn). However, the ability of these innate phagocytic cells to destroy ingested Cn is strongly influenced by polarizat
Externí odkaz:
https://doaj.org/article/ae07982466ca4e43b3029e782d2c1994
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 87-88 (2021)
ABSTRACT IMPACT: This project seeks to identify unique host responses that are biomarkers for specific urethral pathogens, and which can be used in the development of point-of-care (POC) STI diagnostics. OBJECTIVES/GOALS: How Chlamydia trachomatis (C
Externí odkaz:
https://doaj.org/article/6db78147ffae49a7b7ed29591e26105a
Autor:
Suthat Liangpunsakul, Evelyn Toh, Ruth A. Ross, Laura E. Heathers, Kristina Chandler, AdePeju Oshodi, Breann McGee, Elizabeth Modlik, Tobyn Linton, Darrin Mangiacarne, Claudie Jimenez, X. Charlie Dong, Li Wang, Wanzhu Tu, David E. Nelson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract It is unknown if LPS (lipopolysaccharides) and markers of immune activation, soluble CD14 (sCD14) and CD163 (sCD163) are associated with the quantity of alcohol consumption. 148 subjects were enrolled (97 excessive drinkers (ED) and 51 contr
Externí odkaz:
https://doaj.org/article/43223bad8bfa489eae116c4d4e66b2c2
Autor:
Evelyn Toh, Dharanesh Gangaiah, Byron E. Batteiger, James A. Williams, Janet N. Arno, Albert Tai, Teresa A. Batteiger, David E. Nelson
Publikováno v:
Emerging Infectious Diseases, Vol 23, Iss 2, Pp 336-339 (2017)
At a clinic in Indianapolis, Indiana, USA, we observed an increase in Neisseria gonorrhoeae–negative men with suspected gonococcal urethritis who had urethral cultures positive for N. meningitidis. We describe genomes of 2 of these N. meningitidis
Externí odkaz:
https://doaj.org/article/7987ac1321ce46fda55ccb8b29663e52