Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David E, Mold"'
Autor:
Ming Hua Hsu, Ru Chih C. Huang, Jackson Tiffany, Chia-Ching Chang, Kuang-Wen Liao, Cheng Hao Hsieh, Nu Man Tsai, Yu Ling Lin, Hsin Yi Wu, Jung Chang, David E. Mold, Shu Yi Ho
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Cancer progression is associated with the development of antitumor autoantibodies in patients’ sera. Although passive treatment with antitumor antibodies has exhibited remarkable therapeutic efficacy, inhibitory effects on tumor progression by endo
Publikováno v:
Biology of Reproduction. 81:101-110
The two major zona pellucida proteins of the zebrafish chorion, Zp2 and Zp3, are encoded by multicopy genes arranged in tandem arrays on chromosomes 20 and 2, respectively. Expression of these zp genes in zebrafish is oocyte specific, and we report h
Autor:
Yu-Chuan Liang, David E. Mold, Ting-Chao Chou, Chih-Chuan Chang, Chien-Fu Lin, Yuan C. Lee, Ru Chih C. Huang, Athena Klutz, Chuan-I Hsu
Publikováno v:
Cancer Chemotherapy and Pharmacology. 58:640-653
Purpose: Multidrug resistance (MDR) continues to be a major obstacle for successful anticancer therapy. One of the principal factors implicated in MDR is the over expression of P-glycoprotein (Pgp), the product of the MDR1 gene. Methods: Here we expl
Autor:
Yousun Chung, Ru Chih C. Huang, Elaine Lin, Chih-Chuan Chang, Yu-Chuan Liang, Richard Park, Ryan A. Henry, David E. Mold
Publikováno v:
Clinical Cancer Research. 11:4601-4609
Purpose: We have previously shown that the transcriptional inhibitor tetra-O-methyl nordihydroguaiaretic acid (M4N) induces growth arrest in tumor cells and exhibits tumoricidal activity when injected intratumorally into tumor cell explants in mice.
Publikováno v:
Antiviral Research. 58:35-45
Methylated derivatives of nordihydroguaiaretic acid (NDGA)were previously shown to be potent mutation-resistant inhibitors of herpes simplex virus type 1 (HSV-1) which target Sp1 protein binding to critical viral promoters. The hydrophobic nature of
Autor:
Irem Unlu, Kuan Chuan Pao, Szu Chun Wu, Jih Ru Hwu, David E. Mold, Ming Hua Hsu, Ru Chih C. Huang, John N. Gnabre
Publikováno v:
ChemMedChem. 9(5)
Cancer has been a primary global health issue for decades, with hepatocellular carcinoma (HCC) resulting in more than half a million new cases annually. With survival rates as low as
Publikováno v:
Molecular Reproduction and Development. 58:4-14
The proteins of fish egg envelopes are encoded by genes that are closely related to the genes for human zona pellucida proteins. A cluster of three genes coding for an egg envelope protein was isolated from the zebrafish, Danio rerio. The three genes
Publikováno v:
Biology of reproduction. 81(1)
The two major zona pellucida proteins of the zebrafish chorion, Zp2 and Zp3, are encoded by multicopy genes arranged in tandem arrays on chromosomes 20 and 2, respectively. Expression of these zp genes in zebrafish is oocyte specific, and we report h
Publikováno v:
Biochemical and Biophysical Research Communications. 177:1062-1067
The expression of the mouse IAP promoted placental (MIPP) gene was examined in the tissues of the 13.5 day mouse conceptus by Northern hybridization analysis. MIPP transcripts were found in total cellular RNA isolated from the placenta, parietal yolk
Autor:
Wen Nan Tseng, Chen H, Ru Chih C Huang, David E. Mold, Teng L, Jiannong Li, John N. Gnabre, Park R, Hwu
Publikováno v:
Journal of medicinal chemistry. 41(16)
We had previously reported that tetramethyl-O-NGDA (M4N), a synthetic derivative of the naturally occurring nordihydroguaiaretic acid (NDGA), is able to inhibit HIV Tat transactivation by blocking host Sp1 protein at the Sp1 cognate binding site on t