Zobrazeno 1 - 10
of 270
pro vyhledávání: '"David E, Lanfear"'
Autor:
Vandana Revathi Venkateswaran, Ruicong She, Hongsheng Gui, Jasmine A. Luzum, Timothy D. Bryson, Zack E. Malouf, L. Keoki Williams, Hani N. Sabbah, Stephen J. Gardell, David E. Lanfear
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundHeart failure with reduced ejection fraction (HFrEF) remains a significant public health issue, with the disease advancing despite neurohormonal antagonism. Energetic dysfunction is a likely contributor to residual disease progression, and
Externí odkaz:
https://doaj.org/article/287e5fc9fe224a08a4bd65d4e2c80027
Autor:
Ramesh C. Gupta, Vinita Singh-Gupta, Kristina J. Szekely, Kefei Zhang, David E. Lanfear, Hani N. Sabbah
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100067- (2024)
Mitochondrial (MITO) dysfunction occurs in the failing heart and contributes to worsening of heart failure (HF). Reduced aldehyde dehydrogenase 2 (ALDH2) in left ventricular (LV) myocardium of diabetic hearts has been implicated in MITO dysfunction t
Externí odkaz:
https://doaj.org/article/c0dbe2f741d941188b99628c9d1524de
Autor:
R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans‐Peter Brunner‐La Rocca, David J. Carey, Mark D. Chaffin, Daniel I. Chasman, Olympe Chazara, Xing Chen, Xu Chen, Jonathan H. Chung, William Chutkow, John G.F. Cleland, James P. Cook, Simon deDenus, Abbas Dehghan, Graciela E. Delgado, Spiros Denaxas, Alexander S. Doney, Marcus Dörr, Samuel C. Dudley, Gunnar Engström, Tõnu Esko, Ghazaleh Fatemifar, Stephan B. Felix, Chris Finan, Ian Ford, Francoise Fougerousse, René Fouodjio, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John S. Gottdiener, Stefan Gross, Daníel F. Guðbjartsson, Hongsheng Gui, Rebecca Gutmann, Christopher M. Haggerty, Pim van derHarst, Åsa K. Hedman, Anna Helgadottir, Hans Hillege, Craig L. Hyde, Jaison Jacob, J. Wouter Jukema, Frederick Kamanu, Isabella Kardys, Maryam Kavousi, Kay‐Tee Khaw, Marcus E. Kleber, Lars Køber, Andrea Koekemoer, Bill Kraus, Karoline Kuchenbaecker, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Barry London, Luca A. Lotta, Ruth C. Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Douglas Mann, Kenneth B. Margulies, Nicholas A. Marston, Winfried März, John J.V. McMurray, Olle Melander, Giorgio Melloni, Ify R. Mordi, Michael P. Morley, Andrew D. Morris, Andrew P. Morris, Alanna C. Morrison, Michael W. Nagle, Christopher P. Nelson, Christopher Newton‐Cheh, Alexander Niessner, Teemu Niiranen, Christoph Nowak, Michelle L. O'Donoghue, Anjali T. Owens, Colin N.A. Palmer, Guillaume Paré, Markus Perola, Louis‐Philippe Lemieux Perreault, Eliana Portilla‐Fernandez, Bruce M. Psaty, Kenneth M. Rice, Paul M. Ridker, Simon P.R. Romaine, Carolina Roselli, Jerome I. Rotter, Christian T. Ruff, Marc S. Sabatine, Perttu Salo, Veikko Salomaa, Jessica vanSetten, Alaa A. Shalaby, Diane T. Smelser, Nicholas L. Smith, Kari Stefansson, Steen Stender, David J. Stott, Garðar Sveinbjörnsson, Mari‐Liis Tammesoo, Jean‐Claude Tardif, Kent D. Taylor, Maris Teder‐Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp‐Pedersen, Stella Trompet, Danny Tuckwell, Benoit Tyl, Andre G. Uitterlinden, Felix Vaura, Abirami Veluchamy, Peter M. Visscher, Uwe Völker, Adriaan A. Voors, Xiaosong Wang, Nicholas J. Wareham, Peter E. Weeke, Raul Weiss, Harvey D. White, Kerri L. Wiggins, Heming Xing, Jian Yang, Yifan Yang, Laura M. Yerges‐Armstrong, Bing Yu, Faiez Zannad, Faye Zhao, Regeneron Genetics Center, Jemma B. Wilk, Hilma Holm, Naveed Sattar, Steven A. Lubitz, David E. Lanfear, Svati Shah, Michael E. Dunn, Quinn S. Wells, Folkert W. Asselbergs, Aroon D. Hingorani, Marie‐Pierre Dubé, Nilesh J. Samani, Chim C. Lang, Thomas P. Cappola, Patrick T. Ellinor, Ramachandran S. Vasan, J. Gustav Smith
Publikováno v:
ESC Heart Failure, Vol 8, Iss 6, Pp 5531-5541 (2021)
Abstract Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries,
Externí odkaz:
https://doaj.org/article/77600c13420346d3a1c4c66140b2a3c7
Publikováno v:
Cardiology and Therapy, Vol 9, Iss 2, Pp 561-568 (2020)
Abstract Introduction There are limited data on ivabradine therapy in black patients and none in African Americans. We performed an open-label, prospective study at two centers in the United States. African American patients with heart failure (HF) (
Externí odkaz:
https://doaj.org/article/ef5355bd6bd84330a281309aa3e4542f
Autor:
Guodong Pan, Bipradas Roy, Shailendra Giri, David E. Lanfear, Rajarajan A. Thandavarayan, Ashrith Guha, Pablo A. Ortiz, Suresh Selvaraj Palaniyandi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10439 (2022)
To ameliorate diabetes mellitus-associated heart failure with preserved ejection fraction (HFpEF), we plan to lower diabetes-mediated oxidative stress-induced 4-hydroxy-2-nonenal (4HNE) accumulation by pharmacological agents that either decrease 4HNE
Externí odkaz:
https://doaj.org/article/1643a93fb76d4eecaf0366c5b1d9771b
Autor:
Kaleigh L. Evans, Heidi S. Wirtz, Jia Li, Ruicong She, Juan Maya, Hongsheng Gui, Andrew Hamer, Christophe Depre, David E. Lanfear
Publikováno v:
Human Genomics, Vol 13, Iss 1, Pp 1-11 (2019)
Abstract Background Elevated resting heart rate (HR) is a risk factor and therapeutic target in patients with heart failure (HF) and reduced ejection fraction (HFrEF). Previous studies indicate a genetic contribution to HR in population samples but t
Externí odkaz:
https://doaj.org/article/5eda19951fbc4b38a90eab63ebc603d3
Autor:
David E. Lanfear, Joyce N. Njoroge, Kirkwood F. Adams, Inder Anand, James C. Fang, Felix Ramires, Karen Sliwa-Hahnle, Aysha Badat, Lesley Burgess, Eiran Z. Gorodeski, Celeste Williams, Rafael Diaz, Gary M. Felker, John J.V. McMurray, Marco Metra, Scott Solomon, Zi Michael Miao, Brian L. Claggett, Stephen B. Heitner, Stuart Kupfer, Fady I. Malik, John R. Teerlink
Publikováno v:
JACC: Heart Failure. 11:569-579
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc753d950073683c1fc7389273a42c3
https://doi.org/10.1016/j.jchf.2022.11.021
https://doi.org/10.1016/j.jchf.2022.11.021
Autor:
Anthony S Findley, Alan Monziani, Allison L Richards, Katherine Rhodes, Michelle C Ward, Cynthia A Kalita, Adnan Alazizi, Ali Pazokitoroudi, Sriram Sankararaman, Xiaoquan Wen, David E Lanfear, Roger Pique-Regi, Yoav Gilad, Francesca Luca
Publikováno v:
eLife, Vol 10 (2021)
Genetic effects on gene expression and splicing can be modulated by cellular and environmental factors; yet interactions between genotypes, cell type, and treatment have not been comprehensively studied together. We used an induced pluripotent stem c
Externí odkaz:
https://doaj.org/article/669e7973fff1476c8b8f49f8daf487c0
Autor:
Senthil, Selvaraj, Zhuxuan, Fu, Philip, Jones, Lydia C, Kwee, Sheryl L, Windsor, Olga, Ilkayeva, Christopher B, Newgard, Kenneth B, Margulies, Mansoor, Husain, Silvio E, Inzucchi, Darren K, McGuire, Bertram, Pitt, Benjamin M, Scirica, David E, Lanfear, Michael E, Nassif, Ali, Javaheri, Robert J, Mentz, Mikhail N, Kosiborod, Svati H, Shah
Publikováno v:
Circulation. 146(11)
Background: Sodium-glucose cotransporter-2 inhibitors are foundational therapy in patients with heart failure with reduced ejection fraction (HFrEF), but underlying mechanisms of benefit are not well defined. We sought to investigate the relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f8b9870ff2acbe19e09e991ae63ed8
https://pubmed.ncbi.nlm.nih.gov/36095068
https://pubmed.ncbi.nlm.nih.gov/36095068
Autor:
Mandeep R. Mehra, Aditi Nayak, Alanna A. Morris, David E. Lanfear, Hassan Nemeh, Sapna Desai, Aditya Bansal, Cesar Guerrero-Miranda, Shelley Hall, Joseph C. Cleveland, Daniel J. Goldstein, Nir Uriel, Leway Chen, Stephen Bailey, Anelechi Anyanwu, Gerald Heatley, Joyce Chuang, Jerry D. Estep
Publikováno v:
JACC: Heart Failure. 10:948-959
BACKGROUND: Clinical trials inform on average efficacy, but individualized risk assessments for outcome prediction are important in guiding treatment implementation. OBJECTIVES: The authors developed and validated a patient-specific risk score to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b91392eca773d14e0af7150108a2125
https://doi.org/10.1016/j.jchf.2022.08.002
https://doi.org/10.1016/j.jchf.2022.08.002