Zobrazeno 1 - 10
of 139
pro vyhledávání: '"David E, Jane"'
Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Autor:
Jue Xiang Wang, Mark W. Irvine, Erica S. Burnell, Kiran Sapkota, Robert J. Thatcher, Minjun Li, Noriko Simorowski, Arturas Volianskis, Graham L. Collingridge, Daniel T. Monaghan, David E. Jane, Hiro Furukawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold s
Externí odkaz:
https://doaj.org/article/9cf4ff26eb1b4740b5b19c5f54918691
Autor:
Divyan A. Chopra, Kiran Sapkota, Mark W. Irvine, Guangyu Fang, David E. Jane, Daniel T. Monaghan, Shashank M. Dravid
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified but their effects on NMDAR gating remain largely unknown. To this end, we tested t
Externí odkaz:
https://doaj.org/article/9f33dc1aa5444fdbaec987412ab161fc
Autor:
Shahida Mallah, Craig P. Butts, David E. Jane, Lisa-Maria Rečnik, Elek Molnár, Christine L. Willis, Robert J. Thatcher, Graham L. Collingridge
Publikováno v:
Organic & Biomolecular Chemistry. 19:9154-9162
(−)-Arctigenin and a series of new analogues have been synthesised and then tested for their potential as AMPA and kainate receptor antagonists of human homomeric GluA1 and GluK2 receptors expressed in HEK293 cells using a Ca2+ influx assay. In gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cb7c25c579e61e867e9f56cf9c771d
https://doi.org/10.1039/d1ob01653a
https://doi.org/10.1039/d1ob01653a
Autor:
Neil Bannister, R. Rothärmel, Zuner A. Bortolotto, Shashank M. Dravid, Rachael Ingram, Guangyu Fang, Graham L. Collingridge, Kiran Sapkota, A. Volianskis, John Georgiou, Divyan Chopra, Blaise M. Costa, Erica S. Burnell, Mark W. Irvine, David E. Jane, Daniel T. Monaghan, Adina T. Michael-Titus, R. Volianskis
Publikováno v:
Neuropharmacology
Different types of memory are thought to rely on different types of synaptic plasticity, many of which depend on the activation of the N-Methyl-D Aspartate (NMDA) subtype of glutamate receptors. Accordingly, there is considerable interest in the poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9d736cdd516f56b3b2f54ce83ee476
https://hdl.handle.net/10919/111856
https://hdl.handle.net/10919/111856
Autor:
Arturas Volianskis, David E. Jane, John Georgiou, Stafford L. Lightman, Zuner A. Bortolotto, Alen V. Eapen, Diego Fernández-Fernández, Graham L. Collingridge
Publikováno v:
Neuropharmacology
Eapen, A V, Fernández-Fernández, D, Georgiou, J, Bortolotto, Z, Lightman, S, Jane, D E, Volianskis, A & Collingridge, G L 2021, ' Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices ', Neuropharmacology, vol. 201, 108833 . https://doi.org/10.1016/j.neuropharm.2021.108833
Eapen, A V, Fernández-Fernández, D, Georgiou, J, Bortolotto, Z, Lightman, S, Jane, D E, Volianskis, A & Collingridge, G L 2021, ' Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices ', Neuropharmacology, vol. 201, 108833 . https://doi.org/10.1016/j.neuropharm.2021.108833
The GluN2 subunits of N-methyl-d-aspartate receptors (NMDARs) are key drivers of synaptic plasticity in the brain, where the particular GluN2 composition endows the NMDAR complex with distinct pharmacological and physiological properties. Compared to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc66f9192fd8f8343deb7ec88e3766ec
http://europepmc.org/articles/PMC8607330
http://europepmc.org/articles/PMC8607330
Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Autor:
Minjun Li, David E. Jane, Graham L. Collingridge, Erica S. Burnell, Robert J. Thatcher, Kiran Sapkota, Arturas Volianskis, Daniel T. Monaghan, Noriko Simorowski, Hiro Furukawa, Mark W. Irvine, Jue Xiang Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Wang, J X, Irvine, M W, Burnell, E S, Sapkota, K, Thatcher, R J, Li, M, Simorowski, N, Volianskis, A, Collingridge, G L, Monaghan, D T, Jane, D E & Furukawa, H 2020, ' Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors ', Nature Communications, vol. 11, no. 1, 423 . https://doi.org/10.1038/s41467-020-14321-0
Nature Communications
Wang, J X, Irvine, M W, Burnell, E S, Sapkota, K, Thatcher, R J, Li, M, Simorowski, N, Volianskis, A, Collingridge, G L, Monaghan, D T, Jane, D E & Furukawa, H 2020, ' Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors ', Nature Communications, vol. 11, no. 1, 423 . https://doi.org/10.1038/s41467-020-14321-0
Nature Communications
N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88f84ba3487ef9967bcf8d4394ee1ae
Autor:
Sergey Kasparov, Kasumi Kishi, Matt De Both, Matthew J. Huentelman, Anja G. Teschemacher, Valentina Mosienko, Ali Rasooli-Nejad, David E. Jane
Publikováno v:
Neuroglia
Volume 1
Issue 2
Pages 25-380
Mosienko, V, Rasooli-Nejad, A, Kishi, K, De Both, M, Jane, D, Huentelman, M, Kasparov, S & Teschemacher, A 2018, ' Putative Receptors Underpinning L-Lactate Signalling in Locus Coeruleus ', Neuroglia, vol. 1, no. 2, pp. 365-380 . https://doi.org/10.3390/neuroglia1020025
Volume 1
Issue 2
Pages 25-380
Mosienko, V, Rasooli-Nejad, A, Kishi, K, De Both, M, Jane, D, Huentelman, M, Kasparov, S & Teschemacher, A 2018, ' Putative Receptors Underpinning L-Lactate Signalling in Locus Coeruleus ', Neuroglia, vol. 1, no. 2, pp. 365-380 . https://doi.org/10.3390/neuroglia1020025
The importance of astrocytic l-lactate (LL) for normal functioning of neural circuits such as those regulating learning/memory, sleep/wake state, autonomic homeostasis, or emotional behaviour is being increasingly recognised. l-Lactate can act on neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd403aba9aa1e85b25f99cb397fb6a1f
https://doi.org/10.3390/neuroglia1020025
https://doi.org/10.3390/neuroglia1020025
Autor:
David Lodge, Arturas Volianskis, David E. Jane, Zuner A. Bortolotto, Stafford L. Lightman, Heather Kang, Graham L. Collingridge, Rachael Ingram
Publikováno v:
Ingram, R, Kang, H H, Lightman, S, Jane, D, Bortolotto, Z, Collingridge, G, Lodge, D & Volianskis, A 2018, ' Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity ', Neuropharmacology, vol. 142, pp. 30-40 . https://doi.org/10.1016/j.neuropharm.2018.06.008
Ketamine, a channel blocking NMDA receptor antagonist, is used off-label for its psychedelic effects, which may arise from a combination of several inter-related actions. Firstly, reductions of the contribution of NMDA receptors to afferent informati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3830713501ac13d2472e04de70ca3cf
https://doi.org/10.1016/j.neuropharm.2018.06.008
https://doi.org/10.1016/j.neuropharm.2018.06.008
Publikováno v:
Neurochemical Research
Lodge, D, Watkins, J C, Bortolotto, Z, Jane, D & Volianskis, A 2019, ' The 1980s : d-AP5, LTP and a Decade of NMDA Receptor Discoveries ', Neurochemical Research, vol. 44, no. 3, pp. 516-530 . https://doi.org/10.1007/s11064-018-2640-6
Lodge, D, Watkins, J C, Bortolotto, Z, Jane, D & Volianskis, A 2019, ' The 1980s : d-AP5, LTP and a Decade of NMDA Receptor Discoveries ', Neurochemical Research, vol. 44, no. 3, pp. 516-530 . https://doi.org/10.1007/s11064-018-2640-6
In the 1960s and 70s, biochemical and pharmacological evidence was pointing toward glutamate as a synaptic transmitter at a number of distinct receptor classes, known as NMDA and non-NMDA receptors. The field, however, lacked a potent and highly sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f26f62e2e3c04a13680246b5ee199cb
http://europepmc.org/articles/PMC6420420
http://europepmc.org/articles/PMC6420420
Autor:
Shashank M. Dravid, Kiran Sapkota, Daniel T. Monaghan, Erica S. Burnell, David E. Jane, Mark W. Irvine, Guangyu Fang, Dinesh Y. Gawande
Publikováno v:
Neuropharmacology. 201:108818
N-methyl- d -aspartate (NMDA) receptors (NMDARs) are a subtype of ionotropic glutamate receptor with important roles in CNS function. Since excessive NMDAR activity can lead to neuronal cell death and epilepsy, there is interest in developing NMDAR n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6206924b5904f9414ae8507790ab847
https://doi.org/10.1016/j.neuropharm.2021.108818
https://doi.org/10.1016/j.neuropharm.2021.108818