Zobrazeno 1 - 10
of 28
pro vyhledávání: '"David E, Hines"'
Autor:
David E. Hines, Shannon Bell, Xiaoqing Chang, Kamel Mansouri, David Allen, Nicole Kleinstreuer
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Regulatory toxicology testing has traditionally relied on in vivo methods to inform decision-making. However, scientific, practical, and ethical considerations have led to an increased interest in the use of in vitro and in silico methods to fill dat
Externí odkaz:
https://doaj.org/article/920f561cbdbe42558b98fe41907107e9
Autor:
Jingjie Zhang, Xiaoqing Chang, Tessa L. Holland, David E. Hines, Agnes L. Karmaus, Shannon Bell, K. Monica Lee
Publikováno v:
Frontiers in Toxicology, Vol 3 (2022)
In vitro methods offer opportunities to provide mechanistic insight into bioactivity as well as human-relevant toxicological assessments compared to animal testing. One of the challenges for this task is putting in vitro bioactivity data in an in viv
Externí odkaz:
https://doaj.org/article/a9dbac7abeec4c84af8f626123860df6
Autor:
Jingjie, Zhang, Xiaoqing, Chang, Tessa L, Holland, David E, Hines, Agnes L, Karmaus, Shannon, Bell, K Monica, Lee
Publikováno v:
Frontiers in toxicology. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9845533aff18654373e146ea75dbf0ff
https://pubmed.ncbi.nlm.nih.gov/35295123
https://pubmed.ncbi.nlm.nih.gov/35295123
Publikováno v:
Environmental Science & Technology. 53:11002-11012
Exposure to environmental contaminants can lead to adverse outcomes in both human and nonhuman receptors. The Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) frameworks can mechanistically inform cumulative risk assessment for huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b15ca4262c6e5c40edb6d37cd8f83f
https://doi.org/10.1021/acs.est.9b04639
https://doi.org/10.1021/acs.est.9b04639
Autor:
David E. Hines, Annie M. Jarabek
Publikováno v:
Current Opinion in Toxicology. 16:83-92
Modernizing risk assessment methods that underlie risk management decisions developed to protect public and environmental health will require interdisciplinary dialog and communication. Alignment of exposures across traditional data streams such as d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::721cf429df229953056913ed8ba34f50
https://doi.org/10.1016/j.cotox.2019.09.001
https://doi.org/10.1016/j.cotox.2019.09.001
Autor:
David E. Hines, Stuart R. Borrett, Clive Fox, Jacob W. Bentley, Natalia Serpetti, David G. Reid, Johanna J. Heymans
Publikováno v:
Ecological Indicators. 98:239-250
Ecological Network Analysis (ENA) can inform marine management decisions by producing indicators that describe ecosystem health and function. Reporting ENA indicators with uncertainty boundaries lets end-users draw stronger inferences and can increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fa02d0562f7552ab1cacaf9d4f2acf
https://doi.org/10.1016/j.ecolind.2018.11.008
https://doi.org/10.1016/j.ecolind.2018.11.008
Publikováno v:
Environmental Modelling & Software. 101:117-127
Uncertainty analyses show how variability inherent in model parameters affects model outcomes. While conducting uncertainty analyses is considered best practice, technical and conceptual challenges limit applications for network models. This work ada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0227acc674ff5df273543b991ec6c491
https://doi.org/10.1016/j.envsoft.2017.12.011
https://doi.org/10.1016/j.envsoft.2017.12.011
Publikováno v:
Computational Toxicology. 20:100182
Physiologically Based Pharmacokinetic (PBPK) models are often developed using animal data and applied to predict chemical movement and concentration in humans. However, differences in physiology and exposure routes between animal experiments and huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3193ceeac4f2b0952f85645790bf13c
https://doi.org/10.1016/j.comtox.2021.100182
https://doi.org/10.1016/j.comtox.2021.100182
Autor:
Amber B. Daniel, Xiaoqing Chang, David E. Hines, Jaleh Abedini, John P. Rooney, Catherine S. Sprankle, Kamel Mansouri, Bethany Cook, Neepa Choksi, Warren Casey, Agnes L. Karmaus, Shannon M. Bell, Eric McAfee, Jason Phillips, David Allen, Nicole Kleinstreuer
Publikováno v:
Computational Toxicology. 20:100184
New approach methodologies (NAMs) for toxicological applications such as in vitro assays and in silico models generate data that can be useful for assessing potential health impacts of chemicals. The National Toxicology Program’s (NTP’s) Integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0d58ff7be8228f7b39eff119135e7af
https://doi.org/10.1016/j.comtox.2021.100184
https://doi.org/10.1016/j.comtox.2021.100184
Autor:
Johanna J. Heymans, David E. Hines, Natalia Serpetti, Jacob W. Bentley, Gema Hernandez-Milian, Stuart R. Borrett, Clive Fox, David G. Reid
Publikováno v:
ICES Journal of Marine Science.
In this study, we describe the approach taken by the International Council for the Exploration of the Seas Irish Sea benchmark working group (WKIrish), to co-create diet information for six commercial species using fishers' and scientists knowledge a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6ad68864017711367d88e92fe6963c8
https://doi.org/10.1093/icesjms/fsz121
https://doi.org/10.1093/icesjms/fsz121