Zobrazeno 1 - 10
of 494
pro vyhledávání: '"David E, Cohen"'
Autor:
Samuel A. Druzak, Matteo Tardelli, Suzanne G. Mays, Mireille El Bejjani, Xulie Mo, Kristal M. Maner-Smith, Thomas Bowen, Michael L. Cato, Matthew C. Tillman, Akiko Sugiyama, Yang Xie, Haian Fu, David E. Cohen, Eric A. Ortlund
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is a soluble lipid-binding protein that transports phosphatidylcholine (PC) between cellular membranes. To better understand the protective metabolic effects associated with hepati
Externí odkaz:
https://doaj.org/article/dffadf07d2f544bda1ee583c85133fb6
Autor:
Christopher S. Krumm, Renée S. Landzberg, Lavoisier Ramos-Espiritu, Carolina Adura, Xu Liu, Mariana Acuna, Yang Xie, Xu Xu, Matthew C. Tillman, Yingxia Li, J. Fraser Glickman, Eric A. Ortlund, John D. Ginn, David E. Cohen
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101832- (2023)
Objective: Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C-terminal lipid-sensing steroidogenic acute regulatory transfer-related (START) domain, wh
Externí odkaz:
https://doaj.org/article/8de5909740c140df964ea243b24a5e5d
Autor:
Andre Lima Queiroz, Ezequiel Dantas, Shakti Ramsamooj, Anirudh Murthy, Mujmmail Ahmed, Elizabeth R. M. Zunica, Roger J. Liang, Jessica Murphy, Corey D. Holman, Curtis J. Bare, Gregory Ghahramani, Zhidan Wu, David E. Cohen, John P. Kirwan, Lewis C. Cantley, Christopher L. Axelrod, Marcus D. Goncalves
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cancer-associated cachexia is characterized by loss of body weight, skeletal muscle and adipose tissue which relates to higher mortality in cancer patients. Here, the authors show in a lung cancer murine model that both ActRIIB signalling inhibition
Externí odkaz:
https://doaj.org/article/dc0384978f5f41459c1d29179df85639
Autor:
Yue Li, Norihiro Imai, Hayley T. Nicholls, Blaine R. Roberts, Samaksh Goyal, Tibor I. Krisko, Lay-Hong Ang, Matthew C. Tillman, Anne M. Roberts, Mahnoor Baqai, Eric A. Ortlund, David E. Cohen, Susan J. Hagen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localizat
Externí odkaz:
https://doaj.org/article/e474110267a740bcbae71a2b1885f9cd
Publikováno v:
Dermatitis®. 34:191-200
Autor:
Beatrice Bissig-Choisat, Michele Alves-Bezerra, Barry Zorman, Scott A. Ochsner, Mercedes Barzi, Xavier Legras, Diane Yang, Malgorzata Borowiak, Adam M. Dean, Robert B. York, N. Thao N. Galvan, John Goss, William R. Lagor, David D. Moore, David E. Cohen, Neil J. McKenna, Pavel Sumazin, Karl-Dimiter Bissig
Publikováno v:
JHEP Reports, Vol 3, Iss 3, Pp 100281- (2021)
Background & Aims: The accumulation of neutral lipids within hepatocytes underlies non-alcoholic fatty liver disease (NAFLD), which affects a quarter of the world’s population and is associated with hepatitis, cirrhosis, and hepatocellular carcinom
Externí odkaz:
https://doaj.org/article/7ba96564fd1546cca46ae8ba9c189a39
Autor:
Alfonso Rubio-Navarro, Nicolás Gómez-Banoy, Lisa Stoll, Friederike Dündar, Alex M. Mawla, Lunkun Ma, Eric Cortada, Paul Zumbo, Ang Li, Moritz Reiterer, Nathalia Montoya-Oviedo, Edwin A. Homan, Norihiro Imai, Ankit Gilani, Chengyang Liu, Ali Naji, Boris Yang, Angie Chi Nok Chong, David E. Cohen, Shuibing Chen, Jingli Cao, Geoffrey S. Pitt, Mark O. Huising, Doron Betel, James C. Lo
Publikováno v:
Nature Cell Biology. 25:565-578
Autor:
Alice Akinsulie, Christina Burnett, Wilma F. Bergfeld, Donald V. Belsito, David E. Cohen, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Lisa A. Peterson, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth
Publikováno v:
International Journal of Toxicology. 42:23S-35S
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 11 Cocos nucifera (coconut)-derived ingredients, most of which are reported to function as skin-conditioning agents in cosmetic products. The Panel reviewed the available
Autor:
Theodora K. Karagounis, David E. Cohen
Publikováno v:
Current Allergy and Asthma Reports. 23:201-212
Autor:
Faten Taki, Katherine Lopez, Bojana Zupan, Paul Bergin, Melissa D. Docampo, Michele Alves-Bezerra, Judit Gal Toth, Qiuying Chen, Kimon V. Argyropoulos, Luendreo Barboza, Emily Pickup, Nicholas Fancher, Abbi Hiller, Steven Gross, David E. Cohen, Marcel R.M. van den Brink, Miklos Toth
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101357- (2020)
Summary: Regular physical activity improves physical and mental health. Here we found that the effect of physical activity extends to the next generation. Voluntary wheel running of dams, from postpartum day 2 to weaning, increased the social dominan
Externí odkaz:
https://doaj.org/article/b1f84f2de7644b85a679f468b4abd94d