Hybrid‐Mobile Stroke Unit: Opening the Indication Spectrum for Stroke Mimics and Beyond

Autor: Klaus Fassbender, Daniel J. Phillips, Iris Q. Grunwald, Andrea Schottek, Sajid Alam, Saman Perera, Annie Chakrabarti, Robert Moon, Martin Lesmeister, Viola Wagner, Damon Wheddon, David Dommett, Brittany Wells, Rheanne Middleton, Robert Willis, Monika Bachhuber, Fatma Merzou, Stefan Wagenpfeil, Jineesh Thottath, Thomas Bertsch, Silke Walter

Publikováno v: Stroke: Vascular and Interventional Neurology, Vol 3, Iss 1 (2023)

Background Despite proven benefits, the use of single‐purpose mobile stroke units (MSUs) has raised concerns about their effective and cost‐efficient integration into clinical practice, especially when considered for operation in nonurban areas.

Externí odkaz: https://doaj.org/article/6a1c63d93e52443bbee793acb551f62d

Behaviour of [11C]R(?)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4

Autor: Julian C. Matthews, Roger N. Gunn, Dirk Bender, Steen Jakobsen, Christine A. Parker, Stephen T. Knibb, Antony D. Gee, Laurent Martarello, David Dommett, John Brown, Vincent J. Cunningham

Publikováno v: Parker, C A, Matthews, J C, Gunn, R N, Martarello, L, Cunningham, V J, Dommett, D, Knibb, S T, Bender, D, Jakobsen, S, Brown, J & Gee, A D 2005, ' Behaviour of [11C]R(-)-and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4 ', Synapse, vol. 55, no. 4, pp. 270-9 . https://doi.org/10.1002/syn.20114

Cyclic AMP (cAMP) is a continually produced nucleotide which is inactivated by hydrolysis to 5'AMP via phosphodiesterase 4 (PDE4) enzymes. Rolipram is a selective PDE4 inhibitor which exists in two enantiomeric forms, R(-) and S(+). Both of these ena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d355f407b35574363a6c8ef8079b58c
https://doi.org/10.1002/syn.20114