Zobrazeno 1 - 10
of 272
pro vyhledávání: '"David Ding"'
Autor:
David Ding, Ada Y. Shaw, Sam Sinai, Nathan Rollins, Noam Prywes, David F. Savage, Michael T. Laub, Debora S. Marks
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Recent developments in protein design rely on large neural networks with up to 100s of millions of parameters, yet it is unclear which residue dependencies are critical for determining protein function. Here, we show that amino acid preferen
Externí odkaz:
https://doaj.org/article/5b7c1d3e4ad64c33ae3f2f2b7e909e0d
Autor:
Mariano E. Menendez, Suleiman Y. Sudah, Patrick J. Denard, Geoffrey D. Abrams, Brian T. Feeley, Rachel M. Frank, Joseph W. Galvin, Alexander C. Garber, Timothy S. Crall, Scott Crow, Gregory D. Gramstad, Edward Cheung, Landon Fine, John G. Costouros, Ryan Dobbs, Rishi Garg, Mark H. Getelman, Rafael Buerba, Samuel Harmsen, Raffy Mirzayan, Matthew Pifer, Matthew McElvany, C. Benjamin Ma, Erik McGoldrick, Joseph R. Lynch, Sara Jurek, C. Scott Humphrey, David Weinstein, Nathan D. Orvets, Daniel J. Solomon, Liang Zhou, Jason R. Saleh, Jason Hsu, Anup Shah, Anthony Wei, Edward Choung, Dave Shukla, Richard K.N. Ryu, Dawson S. Brown, Armodios M. Hatzidakis, Kyong S. Min, Robert Fan, Dan Guttmann, Anita G. Rao, David Ding, Brett M. Andres, Jonathan Cheah, Cay M. Mierisch, Rudolf G. Hoellrich, Brian Lee, Matthew Tweet, Matthew T. Provencher, J. Brad Butler, Bradford Kraetzer, Raymond A. Klug, Erica M. Burns, Mark A. Schrumpf, David Savin, Christopher Sheu, Brian Magovern, Rafael Williams, Benjamin W. Sears, Michael A. Stone, Matthew Nugent, Gregory V. Gomez, Michael H. Amini
Publikováno v:
Journal of Shoulder and Elbow Surgery. 32:133-140
Advances in the understanding and management of glenoid bone loss in shoulder instability have led to the development of alternative bony reconstruction techniques to the Latarjet using free bone grafts, but little is known about surgeon adoption of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40c3adb8df2365cd58c528c70e6bc81
https://doi.org/10.1016/j.jse.2022.09.001
https://doi.org/10.1016/j.jse.2022.09.001
Autor:
Jennifer Yihong Tan, Adam Alexander Thil Smith, Maria Ferreira da Silva, Cyril Matthey-Doret, Rico Rueedi, Reyhan Sönmez, David Ding, Zoltán Kutalik, Sven Bergmann, Ana Claudia Marques
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2280-2288 (2017)
Summary: Intergenic long noncoding RNAs (lincRNAs) are the largest class of transcripts in the human genome. Although many have recently been linked to complex human traits, the underlying mechanisms for most of these transcripts remain undetermined.
Externí odkaz:
https://doaj.org/article/5d01618d3be54ed7906fef4461536835
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S2. Genetic tools used for dissecting Il6/Stat3/Myc signaling. (A) Scheme of conditional alleles and PCR primers used for assessing the recombination of Pten/ Trp53 genes. (B) Senescence-specific ß-gal staining is detected aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3752ff135b1299d84053c6e9105cff5a
https://doi.org/10.1158/2159-8290.22531532
https://doi.org/10.1158/2159-8290.22531532
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S1. Copy Number Alteration analysis of human prostate cancer confirms loss of PTEN and TP53 genes as a genetic hallmark of metastatic prostate cancer. (A) Co-deletion frequency for PTEN and TP53 in metastatic and primary prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e22326194e1055bee8ad81bfb6aeb82
https://doi.org/10.1158/2159-8290.22531538.v1
https://doi.org/10.1158/2159-8290.22531538.v1
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S7. Pathway to Pten/ Trp53 deficient prostate metastasis and therapy resistance. Pten-loss triggers PIP3 signaling to activate AKT, which prompts activation of the p53/ p21/ p16 tumor suppressors and senescence arrest. Suppressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bc22895428a5ce3e29b0e0edd7fff7
https://doi.org/10.1158/2159-8290.22531517
https://doi.org/10.1158/2159-8290.22531517
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S3. Tools used for targeting of Il6 and Stat3. (A) Il6 neutralizing antibody specifically decreases the proliferation of Pten/ Trp53 deficient primary MEFs. ANOVA, Dunnett's post-hoc test, **p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d772a30845b6c5301745242e6c9f25
https://doi.org/10.1158/2159-8290.22531529.v1
https://doi.org/10.1158/2159-8290.22531529.v1
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S4. Activation of Stat3/Myc signaling is specific to Ptenpc-/-; Trp53pc-/-prostate and leads to stromal expansion. (A) H&E analysis of prostates from all studied genotypes reveals massive stromal expansion after co-deletion of Pt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73377cff08828121e3d85dec1e12d891
https://doi.org/10.1158/2159-8290.22531526
https://doi.org/10.1158/2159-8290.22531526
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S6. Ar expression in primary and metastatic tumors. (A) IHC analysis of the Ar status in RapidCaP lesions shows no significant Ar staining (left panel) while most prostate glands show strong nuclear Ar staining. (B) The wild type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17006186c51f2f4aeec7dc9f87e014a0
https://doi.org/10.1158/2159-8290.22531520
https://doi.org/10.1158/2159-8290.22531520
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure Legends from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03000e137a751529c248cda1232435d7
https://doi.org/10.1158/2159-8290.22531541.v1
https://doi.org/10.1158/2159-8290.22531541.v1