Zobrazeno 1 - 10
of 48
pro vyhledávání: '"David Dilworth"'
Autor:
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102282- (2022)
Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency
Externí odkaz:
https://doaj.org/article/8c9174ed85e342749dbc2bfff8c4fb40
Autor:
Sara Calhoun, Tisza Ann Szeremy Bell, Lukas R. Dahlin, Yuliya Kunde, Kurt LaButti, Katherine B. Louie, Andrea Kuftin, Daniel Treen, David Dilworth, Sirma Mihaltcheva, Christopher Daum, Benjamin P. Bowen, Trent R. Northen, Michael T. Guarnieri, Shawn R. Starkenburg, Igor V. Grigoriev
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Sara Calhoun, Tisza Ann Szeremy Bell, Lukas Dahlin and colleagues characterize the growth and biomass accumulation of a halotolerant microalga Scenedesmus sp. NREL 46B-D3. They sequenced the genome and profiled the transcriptomic and metabolomic resp
Externí odkaz:
https://doaj.org/article/9c63e3da0b6346f6bef149201df4347e
Autor:
Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein arginine methyltransferases (PRMTs) are increasingly recognized as potential therapeutic targets but PRMT7 remains an understudied member of this enzyme family. Here, the authors develop a chemical probe for PRMT7 and apply it to elucidate th
Externí odkaz:
https://doaj.org/article/03bef969e65b4b6bb250bb2886960e81
Autor:
Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna L. Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P. H. Gay, Fengling Li, Levi Blazer, Mohammad S. Eram, Levon Halabelian, David Dilworth, Genna M. Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S. Zakiah A. Talib, Peter J. Brown, Matthieu Schapira, Philipp Kaldis, Ronan C. O’Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, John M. Sanders, Solomon D. Kattar, D. Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
PRDM9 is a PR domain containing histone methyl transferase which expression is normally restricted to the germline that has also been linked to a number of somatic cancers. Here the authors describe the identification of a small molecule that selecti
Externí odkaz:
https://doaj.org/article/38d967925aeb49498c5e1209a2983c26
Autor:
Rashmi Jain, Jerry Jenkins, Shengqiang Shu, Mawsheng Chern, Joel A. Martin, Dario Copetti, Phat Q. Duong, Nikki T. Pham, David A. Kudrna, Jayson Talag, Wendy S. Schackwitz, Anna M. Lipzen, David Dilworth, Diane Bauer, Jane Grimwood, Catherine R. Nelson, Feng Xing, Weibo Xie, Kerrie W. Barry, Rod A. Wing, Jeremy Schmutz, Guotian Li, Pamela C. Ronald
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background The availability of thousands of complete rice genome sequences from diverse varieties and accessions has laid the foundation for in-depth exploration of the rice genome. One drawback to these collections is that most of these ric
Externí odkaz:
https://doaj.org/article/c4d941c6803844ec8b05d609f888dcb6
Autor:
Chunman Zuo, Matthew Blow, Avinash Sreedasyam, Rita C. Kuo, Govindarajan Kunde Ramamoorthy, Ivone Torres-Jerez, Guifen Li, Mei Wang, David Dilworth, Kerrie Barry, Michael Udvardi, Jeremy Schmutz, Yuhong Tang, Ying Xu
Publikováno v:
Biotechnology for Biofuels, Vol 11, Iss 1, Pp 1-15 (2018)
Abstract Background Switchgrass (Panicum virgatum L.) is an important bioenergy crop widely used for lignocellulosic research. While extensive transcriptomic analyses have been conducted on this species using short read-based sequencing techniques, v
Externí odkaz:
https://doaj.org/article/d3bd1c06feb44869a66d14fa00109b24
Autor:
Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/1528be5dba214e53abc1707b3bc5de39
Autor:
Ronan P. Hanley, David Y. Nie, John R. Tabor, Fengling Li, Amin Sobh, Chenxi Xu, Natalie K. Barker, David Dilworth, Taraneh Hajian, Elisa Gibson, Magdalena M. Szewczyk, Peter J. Brown, Dalia Barsyte-Lovejoy, Laura E. Herring, Gang Greg Wang, Jonathan D. Licht, Masoud Vedadi, Cheryl H. Arrowsmith, Lindsey I. James
Publikováno v:
Journal of the American Chemical Society. 145:8176-8188
Autor:
David Dilworth, Matthew J. Blow, Ji E. Lee, Asaf Salamov, Hyunsoo Na, Ronan C. O'Malley, Yuko Yoshinaga, Chris Daum, Matthew Mingay, Yu Zhang, Leo A Baumgart
Publikováno v:
Nature Methods. 18:1499-1505
Organisms orchestrate cellular functions through transcription factor (TF) interactions with their target genes, although these regulatory relationships are largely unknown in most species. Here we report a high-throughput approach for characterizing
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy