Zobrazeno 1 - 8 of 8 pro vyhledávání: '"David Defranco"'
1
Comparison of Succinimidyl [125I]Iodobenzoate with Iodogen Iodination Methods to Study Pharmacokinetics and ADME of Biotherapeutics
Autor: Mengmeng Wang, Alison Joyce, Denise O'Hara, Xin Xu, Jianqing Chen, Mania Kavosi, David Defranco
Publikováno v: Pharmaceutical Research. 31:2810-2821
To assess the application of succinimidyl iodobenzoate (SIB) iodination method in labeling biotherapeutics to study their pharmacokinetics (PK) and biodistribution.An IgG molecule (protein-01) and a 40 KDa protein (protein-02) were evaluated. Pharmac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eac1634c790aec4ccaa2b4019dfda8d
https://doi.org/10.1007/s11095-014-1378-3
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2
Pharmacokinetics and lung distribution of a humanized anti-RAGE antibody in wild-type and RAGE-/-mice
Autor: David DeFranco, Xin Xu, Yulia Vugmeyster, Debra D. Pittman
Publikováno v: mAbs. 2:571-575
A neutralizing antibody to the receptor for the advanced glycation end products (anti-RAGE Ab) was developed as a potential treatment of acute and chronic inflammatory conditions. Previous pharmacology studies demonstrated efficacy of the anti-RAGE a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d4130c6ece8f2029c7d06befa53181
https://doi.org/10.4161/mabs.2.5.13089
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3
Biodistribution of [125I]-labeled therapeutic proteins: Application in protein drug development beyond oncology**All authors are current or former employees of Wyeth, Inc
Autor: Yulia Vugmeyster, David DeFranco, Qin Wang, Pamela Szklut, Xin Xu
Publikováno v: Journal of Pharmaceutical Sciences. 99:1028-1045
The majority of biodistribution studies of therapeutic proteins published to date focus on tumor-targeting agents. In this report we present a number of case studies that demonstrate the utility of biodistribution studies during preclinical developme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b39750c588a7b1e5e999c54440ae8088
https://doi.org/10.1002/jps.21855
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4
Decreased Subcutaneous Bioavailability of an Oxyntomodulin Analog in a Controlled Release Formulation could be Caused by Skin Metabolism in Rats
Autor: Jennifer Spencer-Pierce, David Defranco, Josef Ozer, Mengmeng Wang, Roger Pak, Lei Sun, Shakey Quazi, Ramin Darvair, Xin Xu, Katherine Wright, Mylene Perreault, Jianqing Chen, Iman Zaghloul, Aadithya Krishnan
Publikováno v: Journal of Bioequivalence & Bioavailability.
Objectives In vivo and in vitro studies were conducted to understand the potential cause for the reduced bioavailability of Peptide A, an Oxyntomodulin analog, following subcutaneous administration in the controlled release formulation compared to th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65111e8e22a16d5b1edadfc651a49676
https://doi.org/10.4172/jbb.10000115
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5
Biodistribution of [125I]-labeled therapeutic proteins: application in protein drug development beyond oncology
Autor: Yulia, Vugmeyster, David, DeFranco, Pamela, Szklut, Qin, Wang, Xin, Xu
Publikováno v: Journal of pharmaceutical sciences. 99(2)
The majority of biodistribution studies of therapeutic proteins published to date focus on tumor-targeting agents. In this report we present a number of case studies that demonstrate the utility of biodistribution studies during preclinical developme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa2d2ceeb579156671797fb93283784f
https://pubmed.ncbi.nlm.nih.gov/19569059
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