Zobrazeno 1 - 3
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pro vyhledávání: '"David D. Quiggle"'
Publikováno v:
Chirality. 16:379-387
Information about the potential and extent of bioinversion of chiral drugs in laboratory animal species and humans is critical to the interpretation of preclinical pharm-tox studies with these drugs. Unlike in the dog, guinea pig, and rabbit, in huma
Autor:
Karina M. Gibson, E. David Murray, John D. Mccracken, Darko Kantoci, Douglas D. Leipold, David D. Quiggle, William J. Wechter
Publikováno v:
Life Sciences. 66:745-753
Our previous studies with the mouse model of familial adenomatous polyposis (FAP), C57BL/6J-APCMin/+ or Min mouse, demonstrated the optimal dose for adenoma reduction with R-flurbiprofen was 10 mg/kg/day as an undivided dose. Divided doses exhibited
Autor:
E. David Murray, Youjiang Liu, Darko Kantoci, Resa L. Chase, David D. Quiggle, William J. Wechter, John D. Mccracken, Yoshimitzu Mineyama
Publikováno v:
The Journal of Clinical Pharmacology. 36:540-545
Nonsteroidal antiinflammatory drugs (NSAIDs) are recognized for inhibiting growth of colon tumors in animal models, and for reducing the risk of colon cancer in humans. The mechanisms involved have not been established, but are thought to be related