Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David D. Deininger"'
Autor:
Brian C VanderVen, Ruth J Fahey, Wonsik Lee, Yancheng Liu, Robert B Abramovitch, Christine Memmott, Adam M Crowe, Lindsay D Eltis, Emanuele Perola, David D Deininger, Tiansheng Wang, Christopher P Locher, David G Russell
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004679 (2015)
Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased chemical screen to identify small molecules that inhibit Mtb metabolism within macrophages, we i
Externí odkaz:
https://doaj.org/article/6109150c12bc4f40969bd55a5cb7ecca
Autor:
Pan Li, Alex Aronov, Jianglin Liang, Kira Mcginty, Waal Nathan D, Cameron Stuver Moody, Swett Rebecca Jane, Pamella J. Ford, Qing Tang, David D. Deininger, Simon Giroux, Diane M. Boucher, Steven M. Ronkin, Lauffer David J
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein, we report a novel series of highly potent and selective triazolothiadiazole c-Met inhibitors. Starting with molecule 5, we have applied structure-based drug design principles to identify the triazolothiadiazole ring system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224c37b505a53218d1599fe4fc01cb38
https://europepmc.org/articles/PMC8201751/
https://europepmc.org/articles/PMC8201751/
Autor:
Jianglin Liang, Robert J. Davies, James P. Griffith, Hardwin O'dowd, Cameron Stuver Moody, Elaine Krueger, Philip N. Collier, Yusheng Liao, Upul K. Bandarage, Alex Aronov, Jian Wang, Jingrong Cao, Derek B. Lowe, Veronique Damagnez, Elaine Y. Chin, John D. Doran, Emmanuelle Sizensky, Wojciech Dworakowski, Sudipta Mahajan, David D. Deininger, Marc Jacobs, Jinwang Xu, Arnaud Le Tiran, Suvarna Khare-Pandit, Albert C. Pierce, Suganthi Nanthakumar, Ron Grey, David Messersmith, James A. Henderson, Jon H. Come
Publikováno v:
Journal of Medicinal Chemistry. 61:5245-5256
The lipid kinase phosphoinositide 3-kinase γ (PI3Kγ) has attracted attention as a potential target to treat a variety of autoimmune disorders, including multiple sclerosis, due to its role in immune modulation and microglial activation. By minimizi
Autor:
Christopher Locher, John A. Thomson, Tiansheng Wang, Brian C. VanderVen, Michael Cynamon, Hong Gao, Michael P. Clark, Harmon J. Zuccola, Emanuele Perola, David D. Deininger, Carolyn M. Shoen, Jones Steven, David G. Russell
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(17)
To develop agents for the treatment of infections caused by Mycobacterium tuberculosis , a novel phenotypic screen was undertaken that identified a series of 2- N -aryl thiazole-based inhibitors of intracellular Mycobacterium tuberculosis . Analogs w
Autor:
Patricia Oliver-Shaffer, Yusheng Liao, Steven M. Ronkin, David D. Deininger, Dean Stamos, Qing Tang, Shi-Kai Tian, Joseph Drumm, Arnaud LeTiran, Anne-Laure Grillot, Tiansheng Wang
Publikováno v:
Tetrahedron Letters. 48:5535-5538
Autor:
David D. Deininger, Wonsik Lee, Ruth J. Fahey, David G. Russell, Tiansheng Wang, Lindsay D. Eltis, Adam M. Crowe, Christine Memmott, Brian C. VanderVen, Emanuele Perola, Robert B. Abramovitch, Christopher Locher, Yancheng Liu
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 11, Iss 2, p e1004679 (2015)
PLoS Pathogens, Vol 11, Iss 2, p e1004679 (2015)
Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased chemical screen to identify small molecules that inhibit Mtb metabolism within macrophages, we i
Autor:
Cynthia A. Gates, John A. Thomson, Kevin M. Cottrell, Yu P. Luong, Scott L. Harbeson, Robert B. Perni, John H. Van Drie, David D. Deininger, Roger D. Tung, Shawn D. Britt, Chao Lin, Janos Pitlik, Luc J. Farmer, John J. Court, Yunyi Wei, John Maxwell, Kai Lin, Bhisetti Govinda Rao, Lawrence F. Courtney, Wayne C. Schairer
Publikováno v:
Letters in Drug Design & Discovery. 2:497-502
Autor:
Kai Lin, Joseph L. Kim, Yu-Ping Luong, Janos Pitlik, Wayne C. Schairer, Chao Lin, Roger D. Tung, Robert B. Perni, John A. Thomson, John Maxwell, Luc J. Farmer, Kevin M. Cottrell, Murcko Mark A, Lawrence F. Courtney, Cynthia A. Gates, John J. Court, John H. Van Drie, David D. Deininger, Wilson Keith P, B. Govinda Rao, Scott L. Harbeson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1939-1942
We recently described the identification of an optimized α-ketoamide warhead for our series of HCV NS3·4A inhibitors. We report herein a series of HCV protease inhibitors incorporating 3-alkyl-substituted prolines in P2. These compounds show except
Autor:
Ethan O'malley, Yunyi Wei, Yu-Ping Luong, John H. Van Drie, Lawrence F. Courtney, Scott L. Harbeson, Janos Pitlik, Kai Lin, Roger D. Tung, Young-Choon Moon, Shawn D. Britt, Chao Lin, Luc J. Farmer, B. Govinda Rao, John J. Court, Cynthia A. Gates, John A. Thomson, David D. Deininger, Robert B. Perni, Rhonda B. Levin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1441-1446
The α-ketoamide warhead (e.g., 15) was found to be a practical replacement for aliphatic aldehydes in a series of HCV NS3·4A protease inhibitors. Structure–activity relationships and prime side optimization are discussed.
Autor:
Rhonda B. Levin, Luc J. Farmer, Robert B. Perni, Joseph L. Kim, Janos Pitlik, B. Govinda Rao, J. A. Landro, Wayne C. Schairer, Roger D. Tung, Shawn D. Britt, Cynthia A. Gates, David D. Deininger, John A. Thomson, John H. Van Drie, Lawrence F. Courtney, John Court, Ethan O'malley, Scott L. Harbeson, Yu-Ping Luong, Yunyi Wei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4059-4063
Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the