Zobrazeno 1 - 10
of 30
pro vyhledávání: '"David D. Davey"'
Autor:
Amy Liang, Dao Lentz, Bin Ye, David D. Davey, Karen May, John Parkinson, Beverly King, Hong Ye, Gary Phillips, Robert G. Wei, William J. Guilford, Sabine Schlyer, Lisa M. Mendoza, Selchau Victor, Seock-Kyu Khim, Jih-Lie Tseng, John G. Bauman, Kochanny Monica, Thomas A. Kirkland, Ming Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3891-3894
The synthesis and biological evaluation of a series of N-alkyl glycine amide analogs as LTA(4)-h inhibitors and the importance of the introduction of a benzoic acid group to the potency and pharmacokinetic parameters of our analogs are described. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a67c0a4315dcbeaa6a8190f571d4d2
https://doi.org/10.1016/j.bmcl.2008.06.046
https://doi.org/10.1016/j.bmcl.2008.06.046
Autor:
Marc Adler, Wei Xu, Sunil K. Koovakkat, Eric Pham, Marc Whitlow, Qinglan Huang, David D. Davey, John Parkinson, Gary Phillips, Shendong Yuan, Mark A. Polokoff
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2505-2508
A series of compounds was rationally designed as inhibitors of dimer formation of the inducible isoform of nitric oxide synthase, and subsequent nitric oxide production. The conformation of two fragments obtained from a crystal structure was utilized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f094ecb8c62b6bf4051134d21ded0d57
https://doi.org/10.1016/j.bmcl.2007.02.018
https://doi.org/10.1016/j.bmcl.2007.02.018
Autor:
Jih-Lie Tseng, David D. Davey, Mark A. Polokoff, Gary Phillips, Raju Mohan, Marc Whitlow, Shendong Yuan, Marc Adler, Robert G. Wei, Elena Ho, Wei Xu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2499-2504
A new series of 1-(1,3-benzodioxol-5-ylmethyl)-3-[4-(1H-Imidazol-1-yl)phenoxy]-piperidine analogs were designed and identified as potent and selective inhibitors of NO formation based both on the crystal structure of a murine iNOS Δ114 monomer domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9628deab8af279241de75938f988126
https://doi.org/10.1016/j.bmcl.2007.02.053
https://doi.org/10.1016/j.bmcl.2007.02.053
Autor:
Damian Arnaiz, Gary Phillips, Shawn David Erickson, Marc Whitlow, Margaret Kenrick, James J. Devlin, Gonghua Pan, Cecile Santos, William J. Guilford, Robert G. Wei, Marc Adler, Kurt W. Saionz, Bin Ye, Ron Vergona, John Parkinson, Zuchun Spring Zhao, David D. Davey, Michael Ohlmeyer, Babu Subramanyam, Vidyadhar M. Paradkar, Mark A. Polokoff, Keith A. Eagen, Michael M. Morrissey
Publikováno v:
Journal of Medicinal Chemistry. 50:1146-1157
By the screening of a combinatorial library for inhibitors of nitric oxide (NO) formation by the inducible isoform of nitric oxide synthase (iNOS) using a whole-cell assay, 2-(imidazol-1-yl)pyrimidines were identified. Compounds were found to inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d006ce8377fe93f50d8103040b4acb
https://doi.org/10.1021/jm061319i
https://doi.org/10.1021/jm061319i
Autor:
Sunil K. Koovakkat, Brad O. Buckman, Keith Eagen, Shung Wu, Ng Howard P, Raju Mohan, Wei Xu, Elena Ho, Lan Trinh, Babu Subramanyam, Meg McCarrick, Gary Phillips, Morrissey Michael M, Michael Pinkerton, William J. Guilford, Marc Whitlow, Amy Liang, David D. Davey
Publikováno v:
Journal of Medicinal Chemistry. 45:2484-2493
A novel series of diaryloxypyridines have been designed as selective nanomolar factor Xa (fXa) inhibitors for use as anticoagulants. In this paper, we describe our efforts to identify an additional interaction and a replacement for the distal amidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d684bc55897a8351d1b9be1346519e43
https://doi.org/10.1021/jm0200660
https://doi.org/10.1021/jm0200660
Autor:
Marc Whitlow, Sung-Hou Kim, Jarmila Jancarik, David D. Davey, David R. Light, Marc Adler, Gary Phillips, Galina Rumennik
Publikováno v:
Biochemistry. 39:12534-12542
Factor Xa plays a critical role in the formation of blood clots. This serine protease catalyzes the conversion of prothrombin to thrombin, the first joint step that links the intrinsic and extrinsic coagulation pathways. There is considerable interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d008e20dd19926bb52630bcc6f8bedbd
https://doi.org/10.1021/bi001477q
https://doi.org/10.1021/bi001477q
Autor:
Sunil K. Koovakkat, William J. Guilford, Wei Xu, Brad O. Buckman, Marian Seto, Brain Griedel, David R. Light, Morrissey Michael M, David D. Davey, Kenneth J. Shaw, Damain O. Arnaiz, Amy Liang, Gary Phillips, Zuchun Zhao, Raju Mohan, Marc Whitlow
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 55:1395-1404
Factor Xa is a serine protease which activates thrombin (factor IIa) and plays a key regulatory role in the blood-coagulation cascade. Factor Xa is, therefore, an important target for the design of anti-thrombotics. Both factor Xa and thrombin share
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014adafa43785dad6d1450599562bf33
https://doi.org/10.1107/s0907444999007350
https://doi.org/10.1107/s0907444999007350
Autor:
Joseph Post, Elena Ho, Amy Liang, Ron Vergona, Raju Mohan, Lan Trinh, Marc Whitlow, Janette Walters, Morrissey Michael M, Wei Xu, Josephine Hinchman, Sunil K. Koovakkat, David D. Davey, Gary Phillips, David R. Light, Brad O. Buckman, William J. Guilford, David J. Smith, Kathy White, Mark E. Sullivan, Keith Eagen, Shung Wu, Ng Howard P, Babu Subramanyam, Kenneth J. Shaw
Publikováno v:
Journal of Medicinal Chemistry. 41:3557-3562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27239681e30eb87c628051c339a2324
https://doi.org/10.1021/jm980280h
https://doi.org/10.1021/jm980280h
Autor:
Brian D. Griedel, Keith Eagen, Shung C. Wu, Morrissey Michael M, Yuo-Ling Chou, Karna Lyn Sacchi, Lan Trinh, David D. Davey, Kenneth J. Shaw, Karanjawala Rushad E, Dao Lentz, Kochanny Monica, Amy Liang, Gary Phillips
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(3)
Compound 1 was identified by high throughput screening as a novel, potent, non-amidine factor Xa inhibitor with good selectivity against thrombin and trypsin. A series of modifications of the three aromatic groups of 1 was investigated. Substitution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eac456c84cdeb71df61707321081b28
https://pubmed.ncbi.nlm.nih.gov/12565961
https://pubmed.ncbi.nlm.nih.gov/12565961
Autor:
Kirk Mcmillan, Gonghua Pan, Michael M. Morrissey, Leslie J. Browne, Mark A. Polokoff, Baldwin John J, Ronald Vergona, Gary Phillips, Marc Adler, Michael Ohlmeyer, David D. Davey, John Parkinson, Cornell Mallari, Charles B. Glaser, Nolan H. Sigal, Shawn David Erickson, Keith A. Eagen, James J. Devlin, Tish A. Young, Ronald E. Dolle, Eric Blasko, Daniel Chelsky, Richard I. Feldman, Douglas S. Auld, Marc Whitlow
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(4)
Potent and selective inhibitors of inducible nitric oxide synthase (iNOS) (EC 1.14.13.39 ) were identified in an encoded combinatorial chemical library that blocked human iNOS dimerization, and thereby NO production. In a cell-based iNOS assay (A-172
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8792d464785ae85fa380e5ae1614e67d
https://pubmed.ncbi.nlm.nih.gov/10677491
https://pubmed.ncbi.nlm.nih.gov/10677491