Výsledky vyhledávání - "David D. Chang"

Data from Neutralizing Monoclonal Antibody to Periostin Inhibits Ovarian Tumor Growth and Metastasis

Autor: Dennis J. Slamon, Judith C. Gasson, Beth Y. Karlan, David D. Chang, Lillian Ramos, Romaine E. Saxton, Min Zhu

Periostin, an extracellular matrix protein, is reported to be overexpressed in a variety of human cancers and its functions seem to be linked to tumor metastasis. Our previous results show that engineered periostin overexpression promotes ovarian tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c8b99efb0d78252c9b9870bd694694
https://doi.org/10.1158/1535-7163.c.6535231

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Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation

Autor: David D. Chang, D. Lansing Taylor, Keisuke Kuida, E. David Litwack, Gary J. Kelloff, Caroline C. Sigman, Gregory Friberg, Jerry S.H. Lee, Emily J. Greenspan, Christopher M. Hartshorn, Susan M. Keating, Peter Kuhn, Anne L. Plant

Publikováno v: Clinical and Translational Science. 11:267-276

The high-content interrogation of single cells with platforms optimized for the multiparameter characterization of cells in liquid and solid biopsy samples can enable characterization of heterogeneous populations of cells ex vivo. Doing so will advan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1eb2602288dc71b028c4c4a26d4cc3d
https://doi.org/10.1111/cts.12536

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Neutralizing Monoclonal Antibody to Periostin Inhibits Ovarian Tumor Growth and Metastasis

Autor: Dennis J. Slamon, Lillian Ramos, Judith C. Gasson, David D. Chang, Beth Y. Karlan, Min Zhu, Romaine E. Saxton

Publikováno v: Molecular Cancer Therapeutics. 10:1500-1508

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17086be3dfc3b46d11978ac24347150
https://doi.org/10.1158/1535-7163.mct-11-0046

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Safety, Pharmacokinetics, and Efficacy of AMG 706, an Oral Multikinase Inhibitor, in Patients With Advanced Solid Tumors

Autor: Anthony Polverino, Chaan Ng, Marilyn Mulay, Michael Bass, Robert S. Benjamin, Razelle Kurzrock, Roy S. Herbst, Andy Van Vugt, Michelle Purdom, Antonis Koutsoukos, Jeffrey M. Silverman, Lee S. Rosen, Jeffrey S. Wiezorek, Ren Y. Xu, David D. Chang, Yu Nien Sun

Publikováno v: Journal of Clinical Oncology. 25:2369-2376

Purpose AMG 706 is an investigational, orally bioavailable inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, platelet-derived growth factor receptor, and stem-cell factor receptor. This phase I, dose-finding study evaluated the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169d49ac7825ef7a5ef8fc0525d065e8
https://doi.org/10.1200/jco.2006.07.8170

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EPLIN regulates actin dynamics by cross-linking and stabilizing filaments

Autor: Yuhong Song, Sachi C. Gerbin, David D. Chang, Raymond S. Maul, Kurt J. Amann, Thomas D. Pollard

Publikováno v: The Journal of Cell Biology

Epithelial protein lost in neoplasm (EPLIN) is a cytoskeleton-associated protein encoded by a gene that is down-regulated in transformed cells. EPLIN increases the number and size of actin stress fibers and inhibits membrane ruffling induced by Rac.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0308280a08f1f2222b5bd7e0d59780e
https://doi.org/10.1083/jcb.200212057

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Gene expression in epithelial ovarian carcinoma

Autor: Daniela Matei, Thomas G. Graeber, Rae Lynn Baldwin, David D. Chang, Beth Y. Karlan, Jianyu Rao

Publikováno v: Oncogene. 21:6289-6298

We analysed the mRNA levels corresponding to 12,600 transcripts in primary cultures of ovarian epithelial cells derived from nine normal ovaries and 21 epithelial ovarian carcinoma. The class distinction and hierarchical clustering of expression data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba23f8a980f0f7295d4828d54bdd4a1e
https://doi.org/10.1038/sj.onc.1205785

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ICAP-1, a Novel β1 Integrin Cytoplasmic Domain–associated Protein, Binds to a Conserved and Functionally Important NPXY Sequence Motif of β1 Integrin

Autor: David D. Chang, Healy Smith, Jenny Yi-Chun Liu, Carol Wong

Publikováno v: The Journal of Cell Biology

The cytoplasmic domains of integrins are essential for cell adhesion. We report identification of a novel protein, ICAP-1 (integrin cytoplasmic domain- associated protein-1), which binds to the 1 integrin cytoplasmic domain. The interaction between I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdcfddd1a58e76dfd782f6e9098ef9e
https://doi.org/10.1083/jcb.138.5.1149

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Pharmacodynamic Profile and Clinical Response in Patients with B-Cell Malignancies of Anti-CD19 CAR T-Cell Therapy

Autor: Arianne Perez, Jeff Wiezorek, John M. Rossi, William Y. Go, Margo R. Roberts, David D. Chang, Sean Yoder, Yizhou Jiang, Armen Mardiros, Marika Sherman, James N. Kochenderfer, Lynn Navale, Adrian Bot, Yueh-wei Shen, Steven A. Rosenberg

Publikováno v: Blood. 126:2042-2042

This study is supported in part by funding from the CooperativeResearch and Development Agreement (CRADA) between the National Cancer Institute and Kite Pharma Introduction: Chimeric antigen receptor (CAR) engineered autologous T-cell therapy has sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1a208528d10836664a7f386df381cc6
https://doi.org/10.1182/blood.v126.23.2042.2042

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