Zobrazeno 1 - 10
of 483
pro vyhledávání: '"David D. Anderson"'
Publikováno v:
Volume 3A: 47th Design Automation Conference (DAC).
Computational design methods provide opportunities to discover novel and diverse designs that traditional optimization approaches cannot find or that use physical phenomena in ways that engineers have overlooked. However, existing methods require sup
Publikováno v:
The AAPS Journal. 22
Freeze-drying, also known as lyophilization, is a dehydration process designed to prolong the shelf life of injectable drug products. Here, we provide regulatory considerations for manufacturing processes specific to lyophilized injectable products.
Publikováno v:
Angewandte Chemie. 124:1812-1838
Die Entstehung von Arzneimittelresistenzen ist eines der grundlegenden Probleme der Medizin. Dass sich bei HIV/AIDS so schnell resistente HIV-1-Varianten einstellen, ist ein groses Hindernis fur die modernen Therapien. Wichtige Zielmolekule der derze
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Over the past two decades, HIV protease inhibitors have helped revolutionize the treatment of HIV/AIDS transforming this deadly ailment into a more manageable chronic infection. Due to intensive research in the area, a variety of protease inhibitors
Autor:
Hiroaki Mitsuya, Yuan-Fang Wang, David D. Anderson, Masayuki Amano, Yasuhiro Koh, Yasushi Tojo, Irene T. Weber, Jordan Tang, Abigail Baldridge, Sarang Kulkarni, Andrey Kovalevsky, Lin Hong, Alexander A. Chumanevich, Arun K. Ghosh
Publikováno v:
Journal of Medicinal Chemistry. 52:7689-7705
The structure-based design, synthesis, and biological evaluation of a series of nonpeptidic macrocyclic HIV protease inhibitors are described. The inhibitors are designed to effectively fill in the hydrophobic pocket in the S1'-S2' subsites and retai
Autor:
Yunfeng Tie, Hiroaki Mitsuya, Abigail Baldridge, Irene T. Weber, Marcus W. Noetzel, Yuan-Fang Wang, Heather B. Miller, Sofiya Leshchenko-Yashchuk, David D. Anderson, Arun K. Ghosh, Yasuhiro Koh
Publikováno v:
Journal of Medicinal Chemistry. 52:3902-3914
Structure-based design, synthesis, and biological evaluation of a series of novel HIV-1 protease inhibitors are described. In an effort to enhance interactions with protease backbone atoms, we have incorporated stereochemically defined methyl-2-pyrro
Autor:
Moher Eric D, John Allan Rieck, Richard D. Miller, Tracy K. Ditsworth, David A. Hay, Sandra S. K. Borders, Mindy B. Forst, Richard C. Hoying, and Duane A. Pierson, Joseph A. Turpin, Varie David Lee, Ryan J. Linder, Jason S. Cronin, David D. Anderson, and Jacob R. Remacle, Molly D. Brady, Hoard David W, Paul N. Dodson, Christopher A. Beck
Publikováno v:
Organic Process Research & Development. 11:546-559
A pilot-plant scale desymmetrization of the cyclic meso-epoxide 4b, using a chiral lithium amide prepared from symmetrical diamine 17, was designed and implemented to provide allylic alcohol 3b in high yield and greater than 99% ee. This chiral alcoh
Publikováno v:
Rapid Prototyping Journal. 10:288-296
This paper describes algorithms and software for decomposing CAD models for a new mold manufacturing process called WirePATH™, which uses wire electrical discharge machining (EDM) to reduce mold fabrication time. A decomposition strategy has been d
Autor:
Jeffrey N. Miner, Yue Mao, Loan N. Miller, Michael A. Stashko, Michael J. Coghlan, Brian E. Green, Chun W. Lin, John K. Pratt, Masaki Nakane, Curtis M. Tyree, Ben Lane, David D. Anderson, Douglas H. Falls, Steven W. Elmore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1721-1727
The SAR at C-5 of the 10-methoxy-2,2,4-trimethylbenzopyrano[3,4-f]quinoline core leading to identification of (-) anti 1-methylcyclohexen-3-yl as the optimum substituent that imparts minimal GR mediated in vitro transcriptional activation while maint
Autor:
Matthew Adams, Arun K. Ghosh, David D. Anderson, Nianchun Ma, Beth E. Prichard, Walter M. Bray, Kerstin A. Effenberger, Melissa S. Jurica
Publikováno v:
The Journal of biological chemistry, vol 289, iss 4
Effenberger, KA; Anderson, DD; Bray, WM; Prichard, BE; Ma, N; Adams, MS; et al.(2014). Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide b and its analogs. Journal of Biological Chemistry, 289(4), 1938-1947. doi: 10.1074/jbc.M113.515536. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/44z1p4j7
Effenberger, KA; Anderson, DD; Bray, WM; Prichard, BE; Ma, N; Adams, MS; et al.(2014). Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide b and its analogs. Journal of Biological Chemistry, 289(4), 1938-1947. doi: 10.1074/jbc.M113.515536. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/44z1p4j7
Pladienolide B (PB) is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. There is considerable interest in the compound as a potential chemotherapeutic, as well as a tool to study SF3B1 function in splicing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ee53df6b27a69f60a8602c2a92e38e
https://escholarship.org/uc/item/44z1p4j7
https://escholarship.org/uc/item/44z1p4j7