Zobrazeno 1 - 10
of 333
pro vyhledávání: '"David D McPherson"'
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130906 (2015)
Posterior leaflet prolapse following chordal elongation or rupture is one of the primary valvular diseases in patients with degenerative mitral valves (MVs). Quadrangular resection followed by ring annuloplasty is a reliable and reproducible surgical
Externí odkaz:
https://doaj.org/article/fa9b1a5cf2dc4fc9bb72056f6c186ce9
Autor:
Carolina Lema, Kwai Wa Cheng, Delanderia M. Anderson, Charles C. Miller, Daniel D. Karp, David D. McPherson, Satya Sree N. Kolar
Publikováno v:
Journal of Clinical and Translational Science, Vol 8 (2024)
Translation is the process of turning observations in the research laboratory, clinic, and community into interventions that improve people’s health. The Clinical and Translational Science Awards (CTSA) program is a National Center for Advancing Tr
Externí odkaz:
https://doaj.org/article/3d37b04bedba454e96dca947a8cdafad
Autor:
Sonya R. Kennedy, Maxime Lafond, Kevin J. Haworth, Daniel Suarez Escudero, Dan Ionascu, Brion Frierson, Shaoling Huang, Melvin E. Klegerman, Tao Peng, David D. McPherson, Curtis Genstler, Christy K. Holland
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammatory
Externí odkaz:
https://doaj.org/article/47b03a8ce6094d39a359e684fdee0ea0
Autor:
Xing Yin, Romain Harmancey, Brion Frierson, Jean G. Wu, Melanie R. Moody, David D. McPherson, Shao-Ling Huang
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 343 (2024)
Liposomes as carriers for CRISPR/Cas9 complexes represent an attractive approach for cardiovascular gene therapy. A critical barrier to this approach remains the efficient delivery of CRISPR-based genetic materials into cardiomyocytes. Echogenic lipo
Externí odkaz:
https://doaj.org/article/ef690dc39b7c4000b75859acabbaaf37
Publikováno v:
Reviews in Cardiovascular Medicine, Vol 24, Iss 12, p 367 (2023)
Background: Surgical management of an anterior leaflet prolapse remains comparatively challenging and has led to the lack of any firmly established standard repair techniques, as seen in cases of posterior leaflet prolapse. Chordal transposition repa
Externí odkaz:
https://doaj.org/article/3dca057b6954419e950320a3bfe542a7
Autor:
Sadia Ashraf, O. Howard Frazier, Sylvia Carranza, David D. McPherson, Heinrich Taegtmeyer, Romain Harmancey
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13709 (2023)
G-protein-coupled receptors (GPCRs) are critical regulators of cardiac physiology and a key therapeutic target for the treatment of heart disease. Ectopic olfactory receptors (ORs) are GPCRs expressed in extra-nasal tissues which have recently emerge
Externí odkaz:
https://doaj.org/article/cceca144700347788fc6f9f37e53aeb5
Autor:
Melvin E. Klegerman, Tao Peng, Shao-Ling Huang, Brion Frierson, Melanie R. Moody, Hyunggun Kim, David D. McPherson
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2288 (2023)
We have conducted a stability study of a complex liposomal pharmaceutical product, Atheroglitatide (AGT), stored at three temperatures, 4, 24, and 37 °C, for up to six months. The six parameters measured were functions of liposomal integrity (size a
Externí odkaz:
https://doaj.org/article/640149126785435a967db9f6ded1c6b9
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12844 (2023)
The CRISPR-based genome editing technology, known as clustered regularly interspaced short palindromic repeats (CRISPR), has sparked renewed interest in gene therapy. This interest is accompanied by the development of single-guide RNAs (sgRNAs), whic
Externí odkaz:
https://doaj.org/article/3ae1a92802f34adf97fa7126fff63170
Autor:
Tao Peng, Keith Booher, Melanie R. Moody, Xing Yin, Jaroslaw Aronowski, David D. McPherson, Sean I. Savitz, Hyunggun Kim, Shao-Ling Huang
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1256 (2023)
Xenon (Xe) has shown great potential as a stroke treatment due to its exceptional ability to protect brain tissue without inducing side effects. We have previously developed Xe-loaded liposomes for the ultrasound-activated delivery of Xe into the cer
Externí odkaz:
https://doaj.org/article/8619f4b6de5f4ab3907598ca424596ee
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 861 (2023)
Atherosclerosis is a complex, multi-stage disease characterized by pathological changes across the vascular wall. Endothelial dysfunction, inflammation, hypoxia, and vascular smooth muscle cell proliferation contribute to its progression. An effectiv
Externí odkaz:
https://doaj.org/article/edf05590591546149cc7724056fc9dc2