Zobrazeno 1 - 10
of 38
pro vyhledávání: '"David D L Bowtell"'
Autor:
Ksenija Nesic, John J. Krais, Yifan Wang, Cassandra J. Vandenberg, Pooja Patel, Kathy Q. Cai, Tanya Kwan, Elizabeth Lieschke, Gwo-Yaw Ho, Holly E. Barker, Justin Bedo, Silvia Casadei, Andrew Farrell, Marc Radke, Kristy Shield-Artin, Jocelyn S. Penington, Franziska Geissler, Elizabeth Kyran, Robert Betsch, Lijun Xu, Fan Zhang, Alexander Dobrovic, Inger Olesen, Rebecca Kristeleit, Amit Oza, Iain McNeish, Gayanie Ratnayake, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D. L. Bowtell, Thomas C. Harding, Kevin Lin, Elizabeth M. Swisher, Olga Kondrashova, Clare L. Scott, Neil Johnson, Matthew J. Wakefield
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract PARP inhibitor (PARPi) therapy has transformed outcomes for patients with homologous recombination DNA repair (HRR) deficient ovarian cancers, for example those with BRCA1 or BRCA2 gene defects. Unfortunately, PARPi resistance is common. Mul
Externí odkaz:
https://doaj.org/article/8f0a9b712db94dd79db01d43d570add9
Autor:
Nikki L. Burdett, Madelynne O. Willis, Ahwan Pandey, Laura Twomey, Sara Alaei, Australian Ovarian Cancer Study Group, David D. L. Bowtell, Elizabeth L. Christie
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Whole genome duplication is frequently observed in cancer, and its prevalence in our prior analysis of end-stage, homologous recombination deficient high grade serous ovarian cancer (almost 80% of samples) supports the notion that whole geno
Externí odkaz:
https://doaj.org/article/013c9e26215141a99c7ae28dc191bc0f
Autor:
Nicholas W. Bateman, Tamara Abulez, Anthony R. Soltis, Andrew McPherson, Seongmin Choi, Dale W. Garsed, Ahwan Pandey, Chunqiao Tian, Brian L. Hood, Kelly A. Conrads, Pang-ning Teng, Julie Oliver, Glenn Gist, Dave Mitchell, Tracy J. Litzi, Christopher M. Tarney, Barbara A. Crothers, Paulette Mhawech-Fauceglia, Clifton L. Dalgard, Matthew D. Wilkerson, Mariaelena Pierobon, Emanuel F. Petricoin, Chunhua Yan, Daoud Meerzaman, Clara Bodelon, Nicolas Wentzensen, Jerry S. H. Lee, The APOLLO Research Network, David G. Huntsman, Sohrab Shah, Craig D. Shriver, Neil T. Phippen, Kathleen M. Darcy, David D. L. Bowtell, Thomas P. Conrads, G. Larry Maxwell
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-17 (2024)
Abstract We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue specimens spanning a broad spectrum of purity. We identified patients wit
Externí odkaz:
https://doaj.org/article/24fb205468404dc8816ab7d41beb50e4
Autor:
Lars O Baumbusch, Åslaug Helland, Yun Wang, Knut Liestøl, Marci E Schaner, Ruth Holm, Dariush Etemadmoghadam, Kathryn Alsop, Pat Brown, Australian Ovarian Cancer Study Group, Gillian Mitchell, Sian Fereday, Anna DeFazio, David D L Bowtell, Gunnar B Kristensen, Ole Christian Lingjærde, Anne-Lise Børresen-Dale
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54356 (2013)
Genomic instability and copy number alterations in cancer are generally associated with poor prognosis; however, recent studies have suggested that extreme levels of genomic aberrations may be beneficial for the survival outcome for patients with spe
Externí odkaz:
https://doaj.org/article/51f14e1dde4a4a9fb3f898164a8ee72e
Autor:
Jaclyn Sceneay, Mira C P Liu, Anna Chen, Christina S F Wong, David D L Bowtell, Andreas Möller
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66388 (2013)
Intratumoral hypoxia is a poor prognostic factor associated with reduced disease-free survival in many cancer types, including breast cancer. Hypoxia encourages tumor cell proliferation, stimulates angiogenesis and lymphangiogenesis, and promotes epi
Externí odkaz:
https://doaj.org/article/b5d395d283a44cc7adcf19d61e0fc91d
Autor:
Åslaug Helland, Michael S Anglesio, Joshy George, Prue A Cowin, Cameron N Johnstone, Colin M House, Karen E Sheppard, Dariush Etemadmoghadam, Nataliya Melnyk, Anil K Rustgi, Wayne A Phillips, Hilde Johnsen, Ruth Holm, Gunnar B Kristensen, Michael J Birrer, Australian Ovarian Cancer Study Group, Richard B Pearson, Anne-Lise Børresen-Dale, David G Huntsman, Anna deFazio, Chad J Creighton, Gordon K Smyth, David D L Bowtell
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18064 (2011)
Molecular subtypes of serous ovarian cancer have been recently described. Using data from independent datasets including over 900 primary tumour samples, we show that deregulation of the Let-7 pathway is specifically associated with the C5 molecular
Externí odkaz:
https://doaj.org/article/eedc70b331b9480eb78a640e33754836
Autor:
Catherine Emmanuel, Natalie Gava, Catherine Kennedy, Rosemary L Balleine, Raghwa Sharma, Gerard Wain, Alison Brand, Russell Hogg, Dariush Etemadmoghadam, Joshy George, Australian Ovarian Cancer Study Group, Michael J Birrer, Christine L Clarke, Georgia Chenevix-Trench, David D L Bowtell, Paul R Harnett, Anna deFazio
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17617 (2011)
Molecular events leading to epithelial ovarian cancer are poorly understood but ovulatory hormones and a high number of life-time ovulations with concomitant proliferation, apoptosis, and inflammation, increases risk. We identified genes that are reg
Externí odkaz:
https://doaj.org/article/c1fbcbe16427471bb5979bca2db34802
Autor:
Dariush Etemadmoghadam, Joshy George, Prue A Cowin, Carleen Cullinane, Maya Kansara, Australian Ovarian Cancer Study Group, Kylie L Gorringe, Gordon K Smyth, David D L Bowtell
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15498 (2010)
Genomic amplification of 19q12 occurs in several cancer types including ovarian cancer where it is associated with primary treatment failure. We systematically attenuated expression of genes within the minimally defined 19q12 region in ovarian cell l
Externí odkaz:
https://doaj.org/article/a02c3b62caf04af1895b1316ffbcc34b
Autor:
Kylie L Gorringe, Joshy George, Michael S Anglesio, Manasa Ramakrishna, Dariush Etemadmoghadam, Prue Cowin, Anita Sridhar, Louise H Williams, Samantha E Boyle, Nozomu Yanaihara, Aikou Okamoto, Mitsuyoshi Urashima, Gordon K Smyth, Ian G Campbell, David D L Bowtell, Australian Ovarian Cancer Study
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e815 (2010)
Ovarian cancer is a heterogeneous disease displaying complex genomic alterations, and consequently, it has been difficult to determine the most relevant copy number alterations with the scale of studies to date. We obtained genome-wide copy number al
Externí odkaz:
https://doaj.org/article/bf27f078765340e890a95da9aab9f420
Autor:
Nadja Stiegeler, Dale W. Garsed, George Au-Yeung, David D. L. Bowtell, Viola Heinzelmann-Schwarz, Tibor A. Zwimpfer
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Approximately 50% of tubo-ovarian high-grade serous carcinomas (HGSCs) have functional homologous recombination-mediated (HR) DNA repair, so-called HR-proficient tumors, which are often associated with primary platinum resistance (relapse within six
Externí odkaz:
https://doaj.org/article/73c4df01d7454789b34b722bde87f98e