Zobrazeno 1 - 10
of 985
pro vyhledávání: '"David D, Thomas"'
Autor:
Robyn T. Rebbeck, Bengt Svensson, Jingyan Zhang, Montserrat Samsó, David D. Thomas, Donald M. Bers, Razvan L. Cornea
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Calmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle. However, the structural dynamics by which calmod
Externí odkaz:
https://doaj.org/article/7cf35385c2e841cd82d95bed6b88e184
Autor:
Damien M Rasmussen, Manny M Semonis, Joseph T Greene, Joseph M Muretta, Andrew R Thompson, Silvia Toledo Ramos, David D Thomas, William CK Pomerantz, Tanya S Freedman, Nicholas M Levinson
Publikováno v:
eLife, Vol 13 (2024)
The type II class of RAF inhibitors currently in clinical trials paradoxically activate BRAF at subsaturating concentrations. Activation is mediated by induction of BRAF dimers, but why activation rather than inhibition occurs remains unclear. Using
Externí odkaz:
https://doaj.org/article/908aea3f4eb7430b8ef82e94417a536d
Autor:
Osha Roopnarine, Samantha L. Yuen, Andrew R. Thompson, Lauren N. Roelike, Robyn T. Rebbeck, Philip A. Bidwell, Courtney C. Aldrich, Razvan L. Cornea, David D. Thomas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract We have used FRET-based biosensors in live cells, in a robust high-throughput screening (HTS) platform, to identify small-molecules that alter the structure and activity of the cardiac sarco/endoplasmic reticulum calcium ATPase (SERCA2a). Ou
Externí odkaz:
https://doaj.org/article/d60af476a07b46be82725dcf9dbef5bf
Autor:
Nagamani Vunnam, Malaney C. Young, Elly E. Liao, Chih Hung Lo, Evan Huber, MaryJane Been, David D. Thomas, Jonathan N. Sachs
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
Nimesulide is a nonsteroidal anti-inflammatory drug and a COX-2 inhibitor with antitumor and antiproliferative activities that induces apoptosis in oral, esophagus, breast, and pancreatic cancer cells. Despite being removed from the market due to hep
Externí odkaz:
https://doaj.org/article/8339f8f393c04b4cb0e30efbbd4b2ad7
Autor:
Anthony R. Braun, Noah Nathan Kochen, Samantha L. Yuen, Elly E. Liao, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Publikováno v:
ASN Neuro, Vol 15 (2023)
There is a critical need for small molecules capable of rescuing pathophysiological phenotypes induced by alpha-synuclein (aSyn) misfolding and oligomerization. Building upon our previous aSyn cellular fluorescence lifetime (FLT)-Förster resonance e
Externí odkaz:
https://doaj.org/article/6a357c5ccafa487bb8bcfca0c180fb4b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
Human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) are based on ground-breaking technology that has significantly impacted cardiovascular research. They provide a renewable source of human cardiomyocytes for a variety of applications incl
Externí odkaz:
https://doaj.org/article/af4bedfd4d3c471fb91b5db859d8e7b1
Autor:
Anthony R. Braun, Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D. Evans, William C. K. Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two
Externí odkaz:
https://doaj.org/article/ee6b8563f73c49f68804418a48d07270
Autor:
Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Simon M. Sandford, Susan S. Taylor, Gianluigi Veglia
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity. This study suggests that the reduced allosteric c
Externí odkaz:
https://doaj.org/article/43c1fcd3a0854b83a040ab4779192c9e
Autor:
Sarah E. D. Nelson, Daniel K. Weber, Robyn T. Rebbeck, Razvan L. Cornea, Gianluigi Veglia, David D. Thomas
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract We have used NMR and circular dichroism spectroscopy to investigate the structural and dynamic effects of oxidation on calmodulin (CaM), using peroxide and the Met to Gln oximimetic mutations. CaM is a Ca2+-sensitive regulatory protein that
Externí odkaz:
https://doaj.org/article/36f3e28887f142c5b2edc2e310a92fe1
Autor:
Angus Lindsay, Cory W. Baumann, Robyn T. Rebbeck, Samantha L. Yuen, William M. Southern, James S. Hodges, Razvan L. Cornea, David D. Thomas, James M. Ervasti, Dawn A. Lowe
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Background Dystrophin deficiency sensitizes skeletal muscle of mice to eccentric contraction (ECC)-induced strength loss. ECC protocols distinguish dystrophin-deficient from healthy, wild type muscle, and test the efficacy of therapeutics fo
Externí odkaz:
https://doaj.org/article/9fc4962558974865bb7abc6a1b44cdbc