Zobrazeno 1 - 10
of 332
pro vyhledávání: '"David D, McPherson"'
Autor:
Carolina Lema, Kwai Wa Cheng, Delanderia M. Anderson, Charles C. Miller, Daniel D. Karp, David D. McPherson, Satya Sree N. Kolar
Publikováno v:
Journal of Clinical and Translational Science, Vol 8 (2024)
Translation is the process of turning observations in the research laboratory, clinic, and community into interventions that improve people’s health. The Clinical and Translational Science Awards (CTSA) program is a National Center for Advancing Tr
Externí odkaz:
https://doaj.org/article/3d37b04bedba454e96dca947a8cdafad
Autor:
Sonya R. Kennedy, Maxime Lafond, Kevin J. Haworth, Daniel Suarez Escudero, Dan Ionascu, Brion Frierson, Shaoling Huang, Melvin E. Klegerman, Tao Peng, David D. McPherson, Curtis Genstler, Christy K. Holland
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammatory
Externí odkaz:
https://doaj.org/article/47b03a8ce6094d39a359e684fdee0ea0
Autor:
Xing Yin, Romain Harmancey, Brion Frierson, Jean G. Wu, Melanie R. Moody, David D. McPherson, Shao-Ling Huang
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 343 (2024)
Liposomes as carriers for CRISPR/Cas9 complexes represent an attractive approach for cardiovascular gene therapy. A critical barrier to this approach remains the efficient delivery of CRISPR-based genetic materials into cardiomyocytes. Echogenic lipo
Externí odkaz:
https://doaj.org/article/ef690dc39b7c4000b75859acabbaaf37
Publikováno v:
Reviews in Cardiovascular Medicine, Vol 24, Iss 12, p 367 (2023)
Background: Surgical management of an anterior leaflet prolapse remains comparatively challenging and has led to the lack of any firmly established standard repair techniques, as seen in cases of posterior leaflet prolapse. Chordal transposition repa
Externí odkaz:
https://doaj.org/article/3dca057b6954419e950320a3bfe542a7
Autor:
Melvin E. Klegerman, Tao Peng, Shao-Ling Huang, Brion Frierson, Melanie R. Moody, Hyunggun Kim, David D. McPherson
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2288 (2023)
We have conducted a stability study of a complex liposomal pharmaceutical product, Atheroglitatide (AGT), stored at three temperatures, 4, 24, and 37 °C, for up to six months. The six parameters measured were functions of liposomal integrity (size a
Externí odkaz:
https://doaj.org/article/640149126785435a967db9f6ded1c6b9
Autor:
Tao Peng, Keith Booher, Melanie R. Moody, Xing Yin, Jaroslaw Aronowski, David D. McPherson, Sean I. Savitz, Hyunggun Kim, Shao-Ling Huang
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1256 (2023)
Xenon (Xe) has shown great potential as a stroke treatment due to its exceptional ability to protect brain tissue without inducing side effects. We have previously developed Xe-loaded liposomes for the ultrasound-activated delivery of Xe into the cer
Externí odkaz:
https://doaj.org/article/8619f4b6de5f4ab3907598ca424596ee
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 861 (2023)
Atherosclerosis is a complex, multi-stage disease characterized by pathological changes across the vascular wall. Endothelial dysfunction, inflammation, hypoxia, and vascular smooth muscle cell proliferation contribute to its progression. An effectiv
Externí odkaz:
https://doaj.org/article/edf05590591546149cc7724056fc9dc2
Autor:
Vijay Govindarajan, Arun Kolanjiyil, Nils P. Johnson, Hyunggun Kim, Krishnan B. Chandran, David D. McPherson
Publikováno v:
Royal Society Open Science, Vol 9, Iss 2 (2022)
Transcatheter aortic valve replacement (TAVR) is now a standard treatment for high-surgical-risk patients with severe aortic valve stenosis. TAVR is being explored for broader indications including degenerated bioprosthetic valves, bicuspid valves an
Externí odkaz:
https://doaj.org/article/de196ab99cb8475e94d7bdc4141b8d60
Autor:
Patrick H. Kee, MD, PhD, Melanie R. Moody, BSc, Shao-Ling Huang, PhD, Hyunggun Kim, PhD, Xing Yin, MD, PhD, Tao Peng, MD, Susan T. Laing, MD, Melvin E. Klegerman, PhD, Mohammad H. Rahbar, PhD, Deborah Vela, MD, Curtis Genstler, MD, PhD, Kevin J. Haworth, PhD, Christy K. Holland, PhD, David D. McPherson, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 1-11 (2020)
Summary: Late in-stent restenosis remains a significant problem. Bare-metal stents were implanted into peripheral arteries in miniature swine, followed by direct intra-arterial infusion of nitric oxide–loaded echogenic liposomes (ELIPs) and anti–
Externí odkaz:
https://doaj.org/article/6799d85165144a17bc107c5ee232352d
Autor:
Himanshu Shekhar, Robert T. Kleven, Tao Peng, Arunkumar Palaniappan, Kunal B. Karani, Shaoling Huang, David D. McPherson, Christy K. Holland
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract The development of adjuvant techniques to improve thrombolytic efficacy is important for advancing ischemic stroke therapy. We characterized octafluoropropane and recombinant tissue plasminogen activator (rt-PA)-loaded echogenic liposomes (O
Externí odkaz:
https://doaj.org/article/d1579c4e74a347bc8589b30a95b120f9