Zobrazeno 1 - 10
of 656
pro vyhledávání: '"David Crich"'
Autor:
Ruslans Muhamadejevs, Klara Haldimann, Marina Gysin, David Crich, Kristaps Jaudzems, Sven N. Hobbie
Publikováno v:
ACS Omega, Vol 9, Iss 5, Pp 5876-5887 (2024)
Externí odkaz:
https://doaj.org/article/13ed3f5b27514b8d8f507b95b69761b9
Autor:
Peter R. Andreana, David Crich
Publikováno v:
ACS Central Science, Vol 7, Iss 9, Pp 1454-1462 (2021)
Externí odkaz:
https://doaj.org/article/cf91430de9034036ab6d93d483d4d26b
Autor:
Yifei Wu, Scott D. Pegan, David Crich, Ellison Desrochers, Edward B. Starling, Madelyn C. Hansen, Carson Booth, Lauren Nicole Mullininx, Lei Lou, Kuan Y. Chang, Zhong-Ru Xie
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5371-5380 (2021)
Although scientists around the world have put lots of effort into the development of new treatments for COVID-19 since the outbreak, no drugs except Veklury (remdesivir) have been approved by FDA. There is an urgent need to discover some alternative
Externí odkaz:
https://doaj.org/article/310baa95dfac4bc6ae63923efa9607c0
Publikováno v:
Molecules, Vol 28, Iss 6, p 2816 (2023)
As an underrepresented functional group in bioorganic and medicinal chemistry, the hydroxylamine unit has historically received little attention from the synthetic community. Recent developments, however, suggest that hydroxylamines may have broader
Externí odkaz:
https://doaj.org/article/3e703d304efd40e8996fe93729f72048
Autor:
Yifei Wu, Scott D. Pegan, David Crich, Lei Lou, Lauren Nicole Mullininx, Edward B. Starling, Carson Booth, Andrew Edward Chishom, Kuan Y. Chang, Zhong-Ru Xie
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4397 (2023)
Papain-like protease (PLpro) is critical to COVID-19 infection. Therefore, it is a significant target protein for drug development. We virtually screened a 26,193 compound library against the PLpro of SARS-CoV-2 and identified several drug candidates
Externí odkaz:
https://doaj.org/article/d281d99627ec410ca12fe9151f971a7c
Autor:
Katja Becker, Sha Cao, Anna Nilsson, Maria Erlandsson, Sven-Kevin Hotop, Janis Kuka, Jon Hansen, Klara Haldimann, Solveiga Grinberga, Talia Berruga-Fernández, Douglas L. Huseby, Reza Shariatgorji, Evelina Lindmark, Björn Platzack, Erik C. Böttger, David Crich, Lena E. Friberg, Carina Vingsbo Lundberg, Diarmaid Hughes, Mark Brönstrup, Per E. Andrén, Edgars Liepinsh, Sven N. Hobbie
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103652- (2021)
Background: The clinical-stage drug candidate EBL-1003 (apramycin) represents a distinct new subclass of aminoglycoside antibiotics for the treatment of drug-resistant infections. It has demonstrated best-in-class coverage of resistant isolates, and
Externí odkaz:
https://doaj.org/article/b25c8a267d4642389bf6d5a2908a5a98
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 25 (2022)
The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosome
Externí odkaz:
https://doaj.org/article/69ec20fa2d5a4d578e57d6c384c9c84c
Autor:
Yifei Wu, David Crich, Scott D. Pegan, Lei Lou, Madelyn C. Hansen, Carson Booth, Ellison Desrochers, Lauren Nicole Mullininx, Edward B. Starling, Kuan Y. Chang, Zhong-Ru Xie
Publikováno v:
Molecules, Vol 26, Iss 24, p 7438 (2021)
An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2. Our previous study revealed the inhibitory mechanisms of polyphenols against DNA polymer
Externí odkaz:
https://doaj.org/article/e30c6cbd597d486e848a3419022341cb
Autor:
Stefan Duscha, Heithem Boukari, Dimitri Shcherbakov, Sumantha Salian, Sandrina Silva, Ann Kendall, Takayuki Kato, Rashid Akbergenov, Deborah Perez-Fernandez, Bruno Bernet, Swapna Vaddi, Pia Thommes, Jochen Schacht, David Crich, Andrea Vasella, Erik C. Böttger
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT The emerging epidemic of drug resistance places the development of efficacious and safe antibiotics in the spotlight of current research. Here, we report the design of next-generation aminoglycosides. Discovery efforts were driven by rationa
Externí odkaz:
https://doaj.org/article/e75ab41e6d784ecd8f204ed86b0f4019
Publikováno v:
ARKIVOC, Vol 2005, Iss 6, Pp 339-344 (2005)
Externí odkaz:
https://doaj.org/article/65bd9b7f47bf4902974355b9395df600