Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David Cowie"'
Autor:
Nibedita S. Ray-Bennett, Winifred Ekezie, Isha Biswas, Nimra Iqbal Choudhary, David Cowie, Lasith Dissanayake, Lauren Macleod, Azukaeogo Nnaji, Madhulika Sahoo
Publikováno v:
International Journal of Disaster Risk Science, Vol 15, Iss 3, Pp 359-373 (2024)
Abstract Sexual and reproductive health (SRH) services are crucial for women especially during disasters, to reduce maternal mortality and morbidity from miscarriages, unsafe abortions, and post-abortion complications. This study explored the SRH int
Externí odkaz:
https://doaj.org/article/3d54ae5330f74bb9be16585c4abf6fb4
Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues
Autor:
Simon Plummer, Bobby Beaumont, Matthew Elcombe, Stephanie Wallace, Jayne Wright, Elizabeth F Mcinnes, Richard A Currie, David Cowie
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 155-161 (2021)
Species differences in hepatic metabolism of thyroxine (T4) by uridine diphosphate glucuronosyl transferase (UGT) and susceptibility to thyroid hormone imbalance could underlie differences in thyroid carcinogenesis caused by hepatic enzyme inducers i
Externí odkaz:
https://doaj.org/article/df6e7a9cd963474aa45fe0574be13157
Autor:
Simon Plummer, Bobby Beaumont, Stephanie Wallace, Graeme Ball, Jayne Wright, Liz McInnes, Richard Currie, Rich Peffer, David Cowie
Publikováno v:
Toxicology Reports, Vol 6, Iss , Pp 998-1005 (2019)
Characterisation of the mode of action (MOA) of constitutive androstane receptor (CAR)-mediated rodent liver tumours involves measurement 5 key events including activation of the CAR receptor, altered gene expression, hepatocellular proliferation, cl
Externí odkaz:
https://doaj.org/article/34784676fbeb4bbebd439dbf29108d12
Autor:
Lauraine Y. Swindale, Alexander J. Stevens, Sarah J. Whalley, Richard A. Currie, K. Michael Jessop, Florence Lai, Pei Pei Lim, Elizabeth F. McInnes, David Cowie, Aniko Kende
Publikováno v:
Toxicology Letters. 380:62-68
Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues
Autor:
Elizabeth F. McInnes, Stephanie Wallace, David Cowie, Simon Plummer, Matthew Elcombe, Richard A. Currie, Bobby Beaumont, Jayne Wright
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 155-161 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Species differences in UGT induction could mediate thyroid cancer susceptibility. • The effect of CAR activators on rat thyroid carcinogenesis could be partly explained by differential induction of Ugt 2b17.
Highlights • Species differences in UGT induction could mediate thyroid cancer susceptibility. • The effect of CAR activators on rat thyroid carcinogenesis could be partly explained by differential induction of Ugt 2b17.
Autor:
Liz McInnes, Bobby Beaumont, Graeme Ball, Simon Plummer, David Cowie, Rich Peffer, Stephanie Wallace, Jayne Wright, Richard A. Currie
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 6, Iss, Pp 998-1005 (2019)
Toxicology Reports, Vol 6, Iss, Pp 998-1005 (2019)
Highlights • The first demonstration of phenobarbital-induced hepatocyte proliferation in 3D liver microtissue models. • Integration of quantitative histopathology data with genomics (transcriptomics/proteomics). • In vitro cross-species risk a
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 162(2)
Experimental data demonstrate a mode of action (MOA) for liver tumors in male rats and mice treated with sedaxane that starts with activation of CAR, followed by altered expression of CAR-responsive genes, increased cell proliferation, and eventually
Autor:
Edward L. LeCluyse, Chad Deisenroth, Richard C. Peffer, Melvin E. Andersen, Valerie Y. Soldatow, David Cowie, O. Joseph Trask
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 36
Rodent liver tumors promoted by constitutive androstane receptor (CAR) activation are known to be mediated by key events that include CAR-dependent gene expression and hepatocellular proliferation. Here, an in vitro high content imaging based assay w
Autor:
David Cowie, K. Papachristos, R. Richards-Doran, K. Wolton, S. Wang, N. Kidley, Richard A. Currie, J. Delany, S. Modi
Publikováno v:
Toxicology Letters. 295:S47
Autor:
John Delaney, Sarah Whalley, David Cowie, Nathan Kidley, Caroline Winn, Paul Rawlinson, Aniko Kende, Ryan Richards-Doran, Sandeep Modi, Lauraine Swindale, Richard A. Currie
Publikováno v:
Reproductive Toxicology. 72:19