Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David Covini"'
Autor:
David Covini, Christian Dank, Gerd Bader, Andreas Schrenk, Alessio Ciulli, Heribert Arnhof, Joerg Rinnenthal, Helmut Berger, Maria Rieger, Mark Pearson, Peter Greb, Jale Karolyi-Özguer, Elisabeth Traxler, Nicole Trainor, Teresa Gmaschitz, Markus Spina, Vanessa Roessler, Johannes Popow, Peter Ettmayer, Andreas Zoephel, Darryl B. McConnell, Manfred Koegl, Corinna Wieshofer, Steffen Steurer
Publikováno v:
Journal of Medicinal Chemistry. 62:2508-2520
Focal adhesion tyrosine kinase (PTK2) is often overexpressed in human hepatocellular carcinoma (HCC), and several reports have linked PTK2 depletion and/or pharmacological inhibition to reduced tumorigenicity. However, the clinical relevance of targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041168c396c47ced7df5815bafe781da
https://doi.org/10.1021/acs.jmedchem.8b01826
https://doi.org/10.1021/acs.jmedchem.8b01826
Autor:
Andreas Schrenk, Daniela Häring, Silke Fischer, Stefan Kornigg, Alex G. Waterson, Andreas Mantoulidis, Manfred Koegl, Markus Zeeb, Thomas Gerstberger, Mark Pearson, Wolfgang Hela, Andreas Zoephel, Darryl B. McConnell, Michael Gmachl, Bernadette Sharps, Jale Karolyi-Oezguer, Johann Hoffmann, Franziska Moser, Jason Phan, Teresa Gmaschitz, David Covini, Bernhard Wolkerstorfer, Qi Sun, Lyne Lamarre, Gabriella Siszler, Renate Schnitzer, Moriz Mayer, Dirk Kessler, Katharina Schipany, Petr Knesl, Christian Salamon, Peter Greb, Stephen W. Fesik, Andreas Gollner, Yvonne Scherbantin, Silvia Munico-Martinez, Craig M. Goodwin, Roland Kousek, Jörg Rinnenthal, Jiqing Sai, Christoph Peinsipp, Laetitia J. Martin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Despite decades of research, no approved drugs have been discovered for KRAS. Recently, a pocket occurring on the surface of the active and inactive form of KRAS was found, but, due to its comparatively shallow, polar nature, this pocket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb3a3b7c6eb6eb9f74dfaa7050cde56
https://pubmed.ncbi.nlm.nih.gov/32047043
https://pubmed.ncbi.nlm.nih.gov/32047043
Autor:
Anthony Nichols, David Covini, Anna Quattropani, Jean-François Arrighi, Yves Cambet, Maurizio Maio, Thierry Martin, Olivier Schott, Bernard Françon, Laurence Novo-Perez, Don Simpson, Delphine Marin, Delphine Rivron, Cristina Donini, Agnes Bombrun, Pierre-Alain Vitte, Stefano Crosignani, Wolfgang H. B. Sauer, Isabelle Martinou, Dominique Swinnen, Valerie Eligert, Fabienne Burgat-Charvillon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1516-1519
The discovery of a novel series of S1P1 agonists is described. Starting from a micromolar HTS positive, iterative optimization gave rise to several single-digit nanomolar S1P1 agonists. The compounds were able to induce internalization of the S1P1 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016d011f2a43aa5c6d794dc932148d8b
https://doi.org/10.1016/j.bmcl.2010.01.102
https://doi.org/10.1016/j.bmcl.2010.01.102
Autor:
‡ Anne-Marie De Raemy-Schenk, Dennis Church, Lucia Golzio, Rocco Cirillo, Russell J. Thomas, Anthony Nichols, Enrico Gillio Tos, Claudio Giachetti, David Covini, Claude Barberis, Pittet Pierre-Andre, Anna Quattropani, and André Chollet, Matthias Schwarz, Charles G. Bradshaw, Richard Coxhead, Guidon Ayala, Alexander Scheer, Marc Missotten, Serge Halazy, Jerome Dorbais, Paolo Marinelli, Véronique Colovray
Publikováno v:
Journal of Medicinal Chemistry. 48:7882-7905
We report a novel chemical class of potent oxytocin receptor antagonists showing a high degree of selectivity against the closely related vasopressin receptors (V1a, V1b, V2). An initial compound, 7, was shown to be active in an animal model of prete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8331bc7d41c601cc4716f7b40c5b2b
https://doi.org/10.1021/jm050645f
https://doi.org/10.1021/jm050645f
Autor:
Corinne Gillieron, Christian Chabert, Thomas Rückle, Jasna Klicic, Denise Gretener, Jeffrey P. Shaw, Karen Roulin, Didier Leroy, Fabienne Burgat-Charvillon, Dennis D. Church, Susanna Carboni, Matthias Schwarz, Delphine Valognes, Pierre Alain Vitte, Anthony Nichols, Bernard Françon, Vincent Pomel, Dominique Perrin, David Covini, Montserrat Camps, Christian Rommel
Publikováno v:
Journal of medicinal chemistry. 49(13)
Class I phosphoinositide 3-kinases (PI3Ks), in particular PI3Kgamma, have become attractive drug targets for inflammatory and autoimmune diseases. Here, we disclose a novel series of furan-2-ylmethylene thiazolidinediones as selective, ATP-competitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fba637b877d4efe4f3d46410b3766d
https://pubmed.ncbi.nlm.nih.gov/16789742
https://pubmed.ncbi.nlm.nih.gov/16789742
Publikováno v:
Veterinary Week; 2/23/2024, p10-10, 1p
Autor:
Gollner, Andreas, Weinstabl, Harald, Fuchs, Julian E., Rudolph, Dorothea, Garavel, Geraldine, Hofbauer, Karin S., Karolyi‐Oezguer, Jale, Gmaschitz, Gerhard, Hela, Wolfgang, Kerres, Nina, Grondal, Elisabeth, Werni, Patrick, Ramharter, Juergen, Broeker, Joachim, McConnell, Darryl B.
Publikováno v:
ChemMedChem; 1/8/2019, Vol. 14 Issue 1, p88-93, 6p