Zobrazeno 1 - 10
of 12
pro vyhledávání: '"David Cousin"'
Autor:
Andrew Novak, David Laughton, Rebecca Lane, Emma Blackham, Jennifer Thomas, Elli Chatzopoulou, Joseph Wrigglesworth, Abdul Quddus, Saleh Ahmed, David Cousin, Lorna Duffy, Nathalie Dubois, John Unitt, Katalin Orban, Edward Browne, Michelle Ward, David Mycock, Maria Ieva, Nicholas Bland, Pascal George, Timothy Bourne, Hélène Asnagli, Louise Birch, Geraint Jones
Publikováno v:
Journal of Medicinal Chemistry. 65:16640-16650
Herein, we report the discovery of a first-in-class chemotype 2-(alkylsulfonamido)thiazol-4-yl)acetamides that act as pan-selective inhibitors of cytidine 5'-triphosphate synthetase (CTPS1/2), critical enzymes in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ef9951f3a13e9255109c54a35d4764
https://doi.org/10.1021/acs.jmedchem.2c01446
https://doi.org/10.1021/acs.jmedchem.2c01446
Autor:
Michael Reader, Aurélie Courtin, Steven Howard, Nicola G. Wallis, Jonathan Shannon, Hugh Walton, Christopher William Murray, Joseph E. Coyle, Joanne M. Munck, Alison Jo-Anne Woolford, Torren M. Peakman, David C. Rees, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Marc O'Reilly, Alpesh Shah, David Norton, Valerio Berdini, Lynsey Fazal, Maria Grazia Carr, Charlotte East, Tom D. Heightman, Nicola E. Wilsher, Ildiko Maria Buck, Luke Bevan, Stuart Thomas Onions, Michael Cooke, Justyna Kucia-Tran, Sandra Muench, Nick Palmer, Sharna J. Rich, Vanessa Martins, David Cousin, Puja Pathuri, John P. Watts
Publikováno v:
Journal of medicinal chemistry. 64(16)
Aberrant activation of the mitogen-activated protein kinase pathway frequently drives tumor growth, and the ERK1/2 kinases are positioned at a key node in this pathway, making them important targets for therapeutic intervention. Recently, a number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d0e8543148c5c72af0eca510047c9f
https://pubmed.ncbi.nlm.nih.gov/34387469
https://pubmed.ncbi.nlm.nih.gov/34387469
Autor:
Neil T. Thompson, Charlotte Mary Griffiths-Jones, John Lyons, Vanessa Martins, Nicola E. Wilsher, Tom D. Heightman, Harpreet K Saini, Juan Castro, Stuart Thomas Onions, David Cousin, Nicola G. Wallis, Valerio Berdini, Nick Palmer, Puja Pathuri, Caroline Richardson, Christopher William Murray, Charlotte East, John P. Watts, Marc O'Reilly, Sharna J. Rich, Hugh Walton, James Edward Harvey Day, Aurélie Courtin, Brent Graham, David C. Rees, Hannah Braithwaite, Michael Cooke, Ildiko Maria Buck, Michael Reader, Sandra Muench, Megan Cassidy, Jonathan Shannon, Joanne M. Munck, Alison Jo-Anne Woolford, David Norton, Lynsey Fazal
Publikováno v:
Journal of Medicinal Chemistry. 61:4978-4992
Aberrant activation of the MAPK pathway drives cell proliferation in multiple cancers. Inhibitors of BRAF and MEK kinases are approved for the treatment of BRAF mutant melanoma, but resistance frequently emerges, often mediated by increased signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64bcd2385197c9e1b7f9532e4d26523
https://doi.org/10.1021/acs.jmedchem.8b00421
https://doi.org/10.1021/acs.jmedchem.8b00421
Autor:
Christopher J. Moody, William Lewis, Magdalena B. Foreiter, Marc G. Hummersone, Richard T. Wheelhouse, Helen S. Summers, David Cousin, Tracey D. Bradshaw, Malcolm F. G. Stevens, Jihong Zhang
Publikováno v:
MedChemComm. 9:545-553
A series of 3-(benzyl-substituted)-imidazo[5,1-d]-1,2,3,5-tetrazines (13) and related derivatives with 3-heteromethyl groups has been synthesised and screened for growth-inhibitory activity in vitro against two pairs of glioma cell lines with temozol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37dccf8e94ea21e104fc7ba2b4b0af63
https://doi.org/10.1039/c7md00554g
https://doi.org/10.1039/c7md00554g
Autor:
Dimosthenis Tsapekos, Rebecca Strawbridge, Matteo Cella, Kimberley Goldsmith, Michail Kalfas, Rosie H. Taylor, Samuel Swidzinski, Steven Marwaha, Libby Grey, Elizabeth Newton, Julie Shackleton, Paul J. Harrison, Michael Browning, Catherine Harmer, Hannah Hartland, David Cousins, Stephen Barton, Til Wykes, Allan H. Young
Publikováno v:
BMC Psychiatry, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background A substantial proportion of people with bipolar disorder (BD) experience persistent cognitive difficulties associated with impairments in psychosocial functioning and a poorer disorder course. Emerging evidence suggests that cogni
Externí odkaz:
https://doaj.org/article/35d105528dc743b3b5478ac94e2b9e3d
Autor:
Jihong Zhang, Marc G. Hummersone, David Cousin, Mark Frigerio, Charles S. Matthews, Tracey D. Bradshaw, Malcolm F. G. Stevens
Publikováno v:
MedChemComm. 7:2332-2343
Synthetic routes to 3-substituted imidazo[5,1-d]-1,2,3,5-tetrazines structurally related to temozolomide were explored. Interaction of 4-diazoimidazole-5-carboxamide with an isocyanate afforded high product yields when the isocyanate was available in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3417c9563ac20002166b3b5e835c39ca
https://doi.org/10.1039/c6md00384b
https://doi.org/10.1039/c6md00384b
Autor:
Archana Thakur, Lawrence G Lum, David Cousins, Mark R Conaway, Jason Sanders, Krishni Wijesooriya, James M Larner, Paul W Read, Timothy N Showalter, Cam Nguyen, David W Lain, Kara Romano, Christopher M McLaughlin, Christopher K Luminais, Einsley Janowski, Donald Muller, Kristin Ward, Sunil Dutta, Song Wood, Joe Chen, Ebenezer Asare, Emily Nesbit, Yhana C Chavis, Kristin V Walker
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/f5f31d1471134113b23256076b7d02f8
Autor:
David, Cousin, Marc G, Hummersone, Tracey D, Bradshaw, Jihong, Zhang, Christopher J, Moody, Magdalena B, Foreiter, Helen S, Summers, William, Lewis, Richard T, Wheelhouse, Malcolm F G, Stevens
Publikováno v:
MedChemComm. 9(3)
The synthesis and biological evaluation of imidazotetrazines substituted at N-3 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::731a25fcac8a5741d6beb1c8320ca201
https://pubmed.ncbi.nlm.nih.gov/30108945
https://pubmed.ncbi.nlm.nih.gov/30108945
Autor:
Christopher Luminais, Hamidreza Nourzadeh, Eric Aliotta, Kristin Ward, David Cousins, Timothy Showalter, Bruce Libby
Publikováno v:
Journal of Contemporary Brachytherapy, Vol 14, Iss 5, Pp 423-428 (2022)
Externí odkaz:
https://doaj.org/article/a0eaeb50de2d4a73907b1e8899da01f4
Publikováno v:
Org. Biomol. Chem.. 4:54-62
A concise and convergent route to combretastatin D2 is described together with some preliminary biological data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74d531c4c2aefd332afabeba128232a
https://doi.org/10.1039/b513515j
https://doi.org/10.1039/b513515j