Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration

Autor: Tyler A. Johnson, David Coppage, Jiajiu Shaw, Phillip Crews, Joseph Media, Marcos A. Ogarrio, Frederick A. Valeriote, Erin P. McCauley, Joseph D. Morris, Lauren N Persi, Mani Maheshwari, Taylor C Garcia, Nicole L. McIntosh, Colon V. Cook

Publikováno v: ACS Medicinal Chemistry Letters. 11:108-113

Reinvestigation of mycothiazole (1) revealed picomolar potency (IC50 = 0.00016, 0.00027, 0.00035 μM) against pancreatic, (PANC-1), liver (HepG2), and colon (HCT-116) tumor cell lines. Reevaluation of 1 provided [α]D data indicating Vanuatu specimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25064717cf5b9545371be28eab12d710
https://doi.org/10.1021/acsmedchemlett.9b00302

Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A

Autor: Jeffrey Aubé, Kelin Li, Joseph P. Konopelski, Jason K. Cooper, David Coppage

Publikováno v: Organic letters, vol 20, iss 14
Cooper, JK; Li, K; Aubé, J; Coppage, DA; & Konopelski, JP. (2018). Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A. Organic Letters, 20(14), 4314-4317. doi: 10.1021/acs.orglett.8b01756. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/7s54p7c3

Copyright © 2018 American Chemical Society. A DP4 protocol has been successfully utilized to establish the true structure of the natural product cyclocinamide A, a flexible cyclic peptide with four isolated stereocenters. Benchmarking the necessary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6faa75af76cd4b09dd76717bd4ef088f
https://escholarship.org/uc/item/7s54p7c3

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

Autor: Mary J. Garson, Jean-Marc Nuzillard, Ronald J. Quinn, Charlotte Simmler, Roger G. Linington, Tyler A. Johnson, Precilia Hermanto, Robert Verpoorte, Jian-Min Yue, Craig M. Williams, Guy Lewin, Bradley S. Moore, Dean J. Tantillo, Damien Jeannerat, Jie Li, Ram P. Neupane, Christoph Steinbeck, Nicholas H. Oberlies, James M. Hook, Hermann Stuppner, David G. I. Kingston, Giovanni Appendino, Carla M. Saunders, Jean-Hugues Renault, John B. MacMillan, Asmaa Boufridi, Wolfgang Robien, Mark S. Butler, Orazio Taglialatela-Scafati, Matthias Niemitz, Michael T. Crimmins, David C. Lankin, Luke Hunter, Nai Yun Ji, Philip G. Williams, Mehdi A. Beniddir, Robert J. Capon, Stefan Bluml, Pradeep Dewapriya, Maique W. Biavatti, Thomas J. Schmidt, Harald Gross, Julien Wist, Joo-Won Nam, Bin Gui Wang, Miaomiao Liu, Jonathan Bisson, James B. McAlpine, Ben Shen, Chen Zhang, Phillip Crews, Fernanda Maria Marins Ocampos, David Coppage, Grégory Genta-Jouve, Andersson Barison, José Rivera-Chávez, Young Hae Choi, Sonja Sturm, Hiroyuki Koshino, Hsiau-Wei Lee, Guido F. Pauli, Christoph Seger, Joseph M. Egan, D. Sai Reddy, Mary Kay Harper, William H. Gerwick, Marie Csete, Guohui Pan, Kerry L. McPhail, Andrei G. Kutateladze, Shao-Nong Chen, Zhengren Xu, Tadeusz F. Molinski

Publikováno v: Natural Product Reports
Natural Product Reports, Royal Society of Chemistry, 2019, 36 (1), pp.248-249. ⟨10.1039/C8NP90041H⟩
Natural product reports, vol 36, iss 1
Natural Product Reports, Royal Society of Chemistry, 2019, 36 (1), pp.248-249

With contributions from the global natural product (NP) research community, and continuing the Raw Data Initiative, this review collects a comprehensive demonstration of the immense scientific value of disseminating raw nuclear magnetic resonance (NM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d5ce3ea0d5b7baafafdbd267deee3a
https://doi.org/10.1039/c8np90041h

Cytotoxicity Studies of Fijianolide (a.k.a. Laulimalide) Acetylated Derivatives Against Pancreatic Cancer Cell lines to Investigate New Paths For Therapeutic Development

Autor: David Coppage, Frederick A. Valeriote, Phillip Crews, Nicole L. McIntosh, Tyler A. Johnson, Colon V. Cook

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8f2d0a34270c96d3c970547c813aa0d
https://doi.org/10.33015/dominican.edu/2015.nsm.rp.03