Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk

Autor: Cameron B. Haas, Yu-Ru Su, Paneen Petersen, Xiaoliang Wang, Stephanie A. Bien, Yi Lin, Demetrius Albanes, Stephanie J. Weinstein, Mark A. Jenkins, Jane C. Figueiredo, Polly A. Newcomb, Graham Casey, Loic Le Marchand, Peter T. Campbell, Victor Moreno, John D. Potter, Lori C. Sakoda, Martha L. Slattery, Andrew T. Chan, Li Li, Graham G. Giles, Roger L. Milne, Stephen B. Gruber, Gad Rennert, Michael O. Woods, Steven J. Gallinger, Sonja Berndt, Richard B. Hayes, Wen-Yi Huang, Alicja Wolk, Emily White, Hongmei Nan, Rami Nassir, Noralane M. Lindor, Juan P. Lewinger, Andre E. Kim, David Conti, W. James Gauderman, Daniel D. Buchanan, Ulrike Peters, Li Hsu

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Observational studies have shown higher folate consumption to be associated with lower risk of colorectal cancer (CRC). Understanding whether and how genetic risk factors interact with folate could further elucidate the underlying mechanism.

Externí odkaz: https://doaj.org/article/ea55fb50ab2146d2930d6881db425e35

Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach

Autor: Damaskini Valvi, Douglas I. Walker, Thomas Inge, Scott M. Bartell, Todd Jenkins, Michael Helmrath, Thomas R. Ziegler, Michele A. La Merrill, Sandrah P. Eckel, David Conti, Yongliang Liang, Dean P. Jones, Rob McConnell, Leda Chatzi

Publikováno v: Environment International, Vol 143, Iss , Pp 105957- (2020)

Background: Advances in untargeted metabolomic technologies have great potential for insight into adverse metabolic effects underlying exposure to environmental chemicals. However, important challenges need to be addressed, including how biological r

Externí odkaz: https://doaj.org/article/76a0d6858d014a678c85b432a0ee3e8b

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.

Autor: Ian P M Tomlinson, Luis G Carvajal-Carmona, Sara E Dobbins, Albert Tenesa, Angela M Jones, Kimberley Howarth, Claire Palles, Peter Broderick, Emma E M Jaeger, Susan Farrington, Annabelle Lewis, James G D Prendergast, Alan M Pittman, Evropi Theodoratou, Bianca Olver, Marion Walker, Steven Penegar, Ella Barclay, Nicola Whiffin, Lynn Martin, Stephane Ballereau, Amy Lloyd, Maggie Gorman, Steven Lubbe, COGENT Consortium, CORGI Collaborators, EPICOLON Consortium, Bryan Howie, Jonathan Marchini, Clara Ruiz-Ponte, Ceres Fernandez-Rozadilla, Antoni Castells, Angel Carracedo, Sergi Castellvi-Bel, David Duggan, David Conti, Jean-Baptiste Cazier, Harry Campbell, Oliver Sieber, Lara Lipton, Peter Gibbs, Nicholas G Martin, Grant W Montgomery, Joanne Young, Paul N Baird, Steven Gallinger, Polly Newcomb, John Hopper, Mark A Jenkins, Lauri A Aaltonen, David J Kerr, Jeremy Cheadle, Paul Pharoah, Graham Casey, Richard S Houlston, Malcolm G Dunlop

Publikováno v: PLoS Genetics, Vol 7, Iss 6, p e1002105 (2011)

Genome-wide association studies (GWAS) have identified 14 tagging single nucleotide polymorphisms (tagSNPs) that are associated with the risk of colorectal cancer (CRC), and several of these tagSNPs are near bone morphogenetic protein (BMP) pathway l

Externí odkaz: https://doaj.org/article/c10c8a90b2ce4383b4aa02c682b34728

Data from A Genome-wide Association Study of Early-Onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age

Autor: Alice S. Whittemore, Nancy J. Cox, Douglas F. Easton, Dan Nicolae, Fernando Rivadeneira, Andre G. Uitterlinden, Hanne Meijers-Heijboer, Quinten Waisfisz, Paul Pharoah, Alison M. Dunning, Clare Turnbull, Nazneen Rahman, Jianjun Liu, Astrid Irwanto, Kamila Czene, Per Hall, Carl Blomqvist, Kristiina Aittomäki, Heli Nevanlinna, Norbert Dahmen, Dieter Flesch-Janys, Jennifer Stone, Quang Minh Bui, Daniel F. Schmidt, Enes Makalic, Rebecca Hein, Lars Beckmann, Magdalena Lochmann, Bertram Müller-Myhsok, Rita K. Schmutzler, Alfons Meindl, Stephen J. Chanock, David J. Hunter, Mark Lathrop, Isabel dos Santos Silva, Olivia Fletcher, Julian Peto, Daniel J. Park, Carmel Apicella, Kyriaki Michailidou, Polly Newcomb, Noralane M. Lindor, Mark Jenkins, Robert Haile, Steve Gallinger, David Duggan, David Conti, Eunjung Lee, Regina M. Santella, Graham G. Giles, Melissa C. Southey, Julia A. Knight, Graham Casey, Daniela Seminara, Duncan C. Thomas, Marilie D. Gammon, Giske Ursin, Kathi Malone, Esther M. John, John L. Hopper, Irene Andrulis, Jenny Chang-Claude, Stephanie Melkonian, Maria Argos, Rachelle Brutus, Shantanu Roy, Farzana Jasmine, Jianxin Shi, Anna Felberg, Valerie McGuire, Eric Gamazon, Lin Tong, Brandon L. Pierce, Muhammad G. Kibriya, Jerry Halpern, Habibul Ahsan

Early-onset breast cancer (EOBC) causes substantial loss of life and productivity, creating a major burden among women worldwide. We analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447201ac529828c2509e3c7b7268d0a9
https://doi.org/10.1158/1055-9965.c.6515769

Data from Quantifying the Genetic Correlation between Multiple Cancer Types

Autor: Peter Kraft, Alkes L. Price, Benjamin Neale, David J. Hunter, Christopher A. Haiman, Douglas Easton, Rosalind Eeles, Sonja Berndt, Andrew Chan, Jenny Chang-Claude, Jeroen R. Huyghe, Li Hsu, Brian Wolpin, Harvey Risch, Gloria Petersen, Alison Klein, Rachael Stolzenberg-Solomon, Laufey T. Amundadottir, Thomas A. Sellers, Ellen L. Goode, Hui-Yi Lin, Jennifer B. Permuth, David Conti, Stephen B. Gruber, Kristin Rand, Rayjean J. Hung, Christopher I. Amos, Fredrick R. Schumacher, Brendan Bulik-Sullivan, Hilary Finucane, Sara Lindström

Background: Many cancers share specific genetic risk factors, including both rare high-penetrance mutations and common SNPs identified through genome-wide association studies (GWAS). However, little is known about the overall shared heritability acro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4c8a899e8be2d11d7fbe71b0cf2be2
https://doi.org/10.1158/1055-9965.c.6515397.v1