Zobrazeno 1 - 10
of 91
pro vyhledávání: '"David Cipolla"'
Autor:
David Cipolla, Jimin Zhang, Brice Korkmaz, James D. Chalmers, Jessica Basso, Daniel Lasala, Carlos Fernandez, Ariel Teper, Kevin C. Mange, Walter R. Perkins, Eugene J. Sullivan
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Brensocatib is an oral, selective, reversible inhibitor of dipeptidyl peptidase-1 (DPP-1), responsible for activating neutrophil serine proteases (NSPs) including neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG
Externí odkaz:
https://doaj.org/article/85f654da54af4f9a8406df384ca1cca2
Autor:
Donna M. Konicek, Adam J. Plaunt, Sachin Gharse, Sasha J. Rose, Arielle Dorfman, Amruta Sabnis, Thomas Baker, Helena Gauani, Donald Chun, Zhili Li, Walter R. Perkins, David Cipolla, Vladimir S. Malinin
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2250 (2023)
The increased prevalence of pulmonary methicillin-resistant Staphylococcus aureus (MRSA) infection in patients living with cystic fibrosis (CF) is concerning due to a correlation with reduced life expectancy and lack of available treatment options. R
Externí odkaz:
https://doaj.org/article/489479d94ae3433599532bcbf80b551d
Autor:
Helena Gauani, Thomas Baker, Zhili Li, Vladimir S. Malinin, Walter R. Perkins, Eugene J. Sullivan, David Cipolla
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 934 (2023)
Treprostinil palmitil (TP), a prodrug of treprostinil, is being developed as an inhalation powder (TPIP) for the treatment of patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension due to interstitial lung disease (PH-ILD). In
Externí odkaz:
https://doaj.org/article/901785b5f5b0470397f70a9f2a5e4176
Autor:
Helena Gauani, Thomas Baker, Zhili Li, Vladimir S. Malinin, Walter Perkins, Eugene Sullivan, David Cipolla
Publikováno v:
Frontiers in Drug Delivery, Vol 2 (2022)
Treprostinil palmitil (TP) is a prodrug of treprostinil that has been formulated as an inhaled powder, termed TPIP, for evaluation in patients with pulmonary arterial hypertension. In these characterization studies we investigated the aerosol perform
Externí odkaz:
https://doaj.org/article/cfdaeee1ac7e4fb4aa9fea582832480b
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272575 (2022)
PurposeNeutrophil serine proteases (NSPs) are implicated in numerous inflammatory diseases. Thus, a robust methodology to monitor and quantify NSPs is important to study disease progression and evaluate the effect of pharmacological interventions. A
Externí odkaz:
https://doaj.org/article/2a93b283d3564f1a9866e8426a8f046d
Autor:
Richard W. Chapman, Michel R. Corboz, Carlos Fernandez, Eugene Sullivan, Andy Stautberg, Adam J. Plaunt, Donna M. Konicek, Vladimir Malinin, Zhili Li, David Cipolla, Walter Perkins
Publikováno v:
ERJ Open Research, Vol 7, Iss 1 (2021)
Cough is induced by inhaled prostacyclin analogues including treprostinil (TRE), and, at higher doses, treprostinil palmitil (TP), a prodrug of TRE. In this report, we have investigated mechanisms involved in TRE- and TP-induced cough, using a dry po
Externí odkaz:
https://doaj.org/article/190cdcb737b843978c4edc4c3898f89d
Autor:
David Cipolla, Igor Gonda
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 10, Iss 6, Pp 472-480 (2015)
There are a large number of smokers who want to quit smoking but have failed in their attempts to do so, with many having been unsuccessful at quitting multiple times over their lifetime. The existing marketed nicotine replacement therapies (NRT) hav
Externí odkaz:
https://doaj.org/article/deaff5dc35834486af6a9fad8e7b68f2
Publikováno v:
Pharmaceutics, Vol 8, Iss 1, p 6 (2016)
Except for management of Pseudomonas aeruginosa (PA) in cystic fibrosis, there are no approved inhaled antibiotic treatments for any other diseases or for infections from other pathogenic microorganisms such as tuberculosis, non-tuberculous mycobacte
Externí odkaz:
https://doaj.org/article/3db6ec6426c341538c447e355ca6762b
Autor:
Sandra Anderson, Paul Atkins, Per Bäckman, David Cipolla, Andrew Clark, Evangelia Daviskas, Bernd Disse, Plamena Entcheva-Dimitrov, Rick Fuller, Igor Gonda, Hans Lundbäck, Bo Olsson, Jeffry Weers
Publikováno v:
Pharmacological Reviews. 74:48-118
The purpose of this review is to summarize essential pharmacological, pharmaceutical, and clinical aspects in the field of orally inhaled therapies that may help scientists seeking to develop new products. After general comments on the rationale for
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 165:219-243
Extensive research into prodrug modification of active pharmaceutical ingredients and nanoparticle drug delivery systems has led to unprecedented levels of control over the pharmacological properties of drugs and resulted in the approval of many prod