Zobrazeno 1 - 10
of 343
pro vyhledávání: '"David Chambers"'
Autor:
Lynda Zeboudj, George Sideris-Lampretsas, Rita Silva, Sabeha Al-Mudaris, Francesca Picco, Sarah Fox, David Chambers, Marzia Malcangio
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Neuropathic pain remains poorly managed by current therapies, highlighting the need to improve our knowledge of chronic pain mechanisms. In neuropathic pain models, dorsal root ganglia (DRG) nociceptive neurons transfer miR-21 packaged in extracellul
Externí odkaz:
https://doaj.org/article/fc2220f0626b4bac8a735b3fa93c7709
Autor:
Prajakta Adsul, David Chambers, Heather M. Brandt, Maria E. Fernandez, Shoba Ramanadhan, Essie Torres, Jennifer Leeman, Barbara Baquero, Linda Fleischer, Cam Escoffery, Karen Emmons, Montserrat Soler, April Oh, Ariella R. Korn, Stephanie Wheeler, Rachel C. Shelton
Publikováno v:
Implementation Science Communications, Vol 3, Iss 1, Pp 1-13 (2022)
Abstract Background The past decade of research has seen theoretical and methodological advances in both implementation science and health equity research, opening a window of opportunity for facilitating and accelerating cross-disciplinary exchanges
Externí odkaz:
https://doaj.org/article/14d045faaf7042968fd0899702ee67cf
Publikováno v:
Experimental Gerontology, Vol 174, Iss , Pp 112127- (2023)
Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery governing cellular senescence, with several known to regulate important genes associated with this process.We sou
Externí odkaz:
https://doaj.org/article/3fbaf0b0ec904a9894f2220534270df1
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Background Beta cell identity changes occur in the islets of donors with diabetes, but the molecular basis of this remains unclear. Protecting residual functional beta cells from cell identity changes may be beneficial for patients with diab
Externí odkaz:
https://doaj.org/article/cf3290657dfa4fb7a48a41855ea1f38b
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The synovial tissue is an immunologically challenging environment where, under homeostatic conditions, highly specialized subsets of immune-regulatory macrophages and fibroblasts constantly prevent synovial inflammation in response to cartilage- and
Externí odkaz:
https://doaj.org/article/de362a065b6d4c9b833891f8d2d48541
Autor:
Robert Mitchell, Ben Mellows, Jonathan Sheard, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, James E. Tomkins, Bernd Denecke, Luca Musante, Barbara Joch, Florence Debacq-Chainiaux, Harry Holthofer, Steve Ray, Tobias B. Huber, Joern Dengjel, Paolo De Coppi, Darius Widera, Ketan Patel
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Abstract Background The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell types that would repl
Externí odkaz:
https://doaj.org/article/71390462c4da442ea58f57b8dc9a8551
Publikováno v:
Molecules, Vol 27, Iss 7, p 2049 (2022)
Background: We have previously reported that the endocannabinoid receptor inverse agonist AM630 is a potent inhibitor of isocitrade dehydrogenase-1 wild-type glioblastoma (GBM) core tumour cell proliferation. To uncover the mechanism behind the anti-
Externí odkaz:
https://doaj.org/article/b98ddec68cb444c68d4b78c340647517
Autor:
Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Activin/myostatin signalling acts to induce skeletal muscle atrophy in adult mammals by inhibiting protein synthesis as well as promoting protein and organelle turnover. Numerous strategies have been successfully developed to attenuate the signalling
Externí odkaz:
https://doaj.org/article/1e65bc7c08914ed5ba9bfcfb9194b54f
Autor:
Danielle Vaughan, Olli Ritvos, Robert Mitchell, Oliver Kretz, Maciej Lalowski, Helge Amthor, David Chambers, Antonios Matsakas, Arja Pasternack, Henry Collins-Hooper, Randy Ballesteros, Tobias B. Huber, Bernd Denecke, Darius Widera, Abir Mukherjee, Ketan Patel
Publikováno v:
European Journal of Translational Myology (2020)
Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer cachexia and sarcopenia. However there have been conc
Externí odkaz:
https://doaj.org/article/09e0948256164d728487d1212eb609fd
Autor:
Raffaele Simeoli, Karli Montague, Hefin R. Jones, Laura Castaldi, David Chambers, Jayne H. Kelleher, Valentina Vacca, Thomas Pitcher, John Grist, Hadil Al-Ahdal, Liang-Fong Wong, Mauro Perretti, Johnathan Lai, Peter Mouritzen, Paul Heppenstall, Marzia Malcangio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury.
Externí odkaz:
https://doaj.org/article/985f58856e554adfb658898c61646afe