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pro vyhledávání: '"David Cameron Wraith"'
Autor:
Graham J Britton, Rachel Ambler, Danielle J Clark, Elaine V Hill, Helen M Tunbridge, Kerrie E McNally, Bronwen R Burton, Philomena Butterweck, Catherine Sabatos-Peyton, Lea A Hampton-O’Neil, Paul Verkade, Christoph Wülfing, David Cameron Wraith
Publikováno v:
eLife, Vol 6 (2017)
Notch is a critical regulator of T cell differentiation and is activated through proteolytic cleavage in response to ligand engagement. Using murine myelin-reactive CD4 T cells, we demonstrate that proximal T cell signaling modulates Notch activation
Externí odkaz:
https://doaj.org/article/75afcfe3d41645f7a11ec23c03da7a47
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The immune system evolved to respond to foreign invaders and prevent autoimmunity to self-antigens. Several types of regulatory T cells facilitate the latter process. These include a subset of Foxp3- CD4+ T cells able to secrete IL-10 in an antigen-s
Externí odkaz:
https://doaj.org/article/4ffcc4d73da3453698bc9278937230b1