Výsledky vyhledávání - "David Caianiello"

Bifunctional small molecules that mediate the degradation of extracellular proteins

Autor: David Spiegel, Jason Ray, David M McDonald, Viswanathan Muthusamy, Rebecca Howell, Angela Z Gong, David Caianiello, Mengwen Zhang, Jake C Swartzel, Venkata R. Sabbasani, Egor Chirkin, Emily M J Branham

Publikováno v: Nature Chemical Biology. 17:947-953

Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy. Most TPD technologies use the ubiquitin-proteasome system, and are therefore limited to targeting intracellular proteins. To address this limitation, we developed a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::574d051ff5b7bfbaf233fa5c99bf18d8
https://doi.org/10.1038/s41589-021-00851-1

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The Chirality of Aggregated Yariv Reagents Correlates with Their AGP‐Binding Ability**

Autor: David Caianiello, Sarah Weingarten, Helene Kuhn, Blaise W. Leeber, Michael Saladino, Amit Basu, Natalie Palaychuk, Brandon Dale, Robert Lusi, Raghuraj Hoshing

Publikováno v: ChemBioChem. 23

Yariv reagents are glycosylated triphenylazo dyes that bind to arabinogalactan proteins (AGPs), proteoglycans found in plant cell walls that are integral for plant growth and development. Yariv reagents are widely utilized as imaging, purification, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f3047765b447c4effe1cc3ed62d2a2
https://doi.org/10.1002/cbic.202100532

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The Chirality of Yariv Reagent Aggregates Correlates with AGP–binding Ability

Autor: Brandon Dale, David Caianiello, Blaise W. Leeber, Robert Lusi, Michael Saladino, Amit Basu, Sarah Weingarten, Natalie Palaychuk, Raghuraj Hoshing, Helene Kuhn

Yariv reagents are glycosylated triphenylazo dyes, some of which bind to the polysaccharide component of arabinogalactan proteins (AGPs), proteoglycans found in plant cell walls. However, the exact reason for the selectivity in the presence/absence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536b5a3b5f51e276de55d132d2b4a5c6
https://doi.org/10.26434/chemrxiv.13154261.v1

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Bifunctional Small Molecules That Mediate the Degradation of Extracellular Proteins

Autor: David Spiegel, Egor Chirkin, Angela Gong, Jason Ray, Viswanathan Muthusamy, Venkata R. Sabbasani, Jake C Swartzel, David A. McDonald, Mengwen Zhang, Emily M J Branham, David Caianiello

Targeted protein degradation (TPD) has emerged as a promising and exciting therapeutic strategy. The majority of existing TPD technologies rely on the ubiquitin-proteasome system, and are therefore limited to targeting intracellular proteins. To addr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca82b0145f706a1f0850afa695a4014
https://doi.org/10.26434/chemrxiv.12732689

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An Improved Protocol for the Synthesis and Purification of Yariv Reagents

Autor: Raghuraj Hoshing, Michael Saladino, Amit Basu, Robert Lusi, Helene Kuhn, David Caianiello

Yariv reagents are widely used tools to study plant proteoglycans known as the Arabinogalactan proteins (AGPs). Despite widespread use of the Yariv reagent in the study of AGPs and several reports of synthetic protocols, there remains a lack of a sim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8bd3a886b089b185fcd2c3f1ea635b
https://doi.org/10.26434/chemrxiv.12525284

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Multi-site Validation of a SARS-CoV-2 IgG/IgM Rapid Antibody Detection Kit

Autor: Morgan E. Levine, David Spiegel, Jesse Collinski, Si Hui Pan, Joseph M. Vinetz, Christopher Minteer, Jason Ray, Tao Li, Arnau Casanovas-Massana, Rebecca Howell, Robert Hale, David Caianiello, Edward deRamon, Albert I. Ko, Linda Wang, David A. McDonald

Deaths from coronavirus disease (COVID-19) have exceeded 300,000 persons globally, calling for rapid development of mobile diagnostics that can assay widespread prevalence and infection rates. Data provided in this study supports the utility of a new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268d41c69e56d1cd13e40cd8f8df75e2
https://doi.org/10.1101/2020.05.25.20112227

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