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of 8
pro vyhledávání: '"David C.F. Sealey"'
Autor:
Michael A.S. Taboski, David C.F. Sealey, Jennifer Dorrens, Chandrakant Tayade, Dean H. Betts, Lea Harrington
Publikováno v:
Cell Reports, Vol 1, Iss 2, Pp 91-98 (2012)
Despite the importance of telomere maintenance in cancer cell survival via the elongation of telomeres by telomerase reverse transcriptase (TERT) or alternative lengthening of telomeres (ALT), it had not been tested directly whether telomere maintena
Externí odkaz:
https://doaj.org/article/60ffbb45b53d46488b9f7e62a4031ee5
Autor:
Ahmed El-Boraie, Stefanie Mak, David C.F. Sealey, Katelyn. J. Kozma, Jonathan Chio, Anne Meyer-Miner
Publikováno v:
Canadian Journal of Career Development. 20:84-93
In the life sciences, many graduate students and postdoctoral fellows find it challenging to enter the non-academic workforce after completing their programs. Through experiential learning, trainees can develop the knowledge, technical skills, soft s
To better understand how PhD graduates have prepared for the non-academic job market, we surveyed life science PhD and postdoctoral graduates from the University of Toronto who were employed in non-academic sectors. We also surveyed life science PhD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4cefc67870edc64c0e037cb4acab97a
Autor:
David C.F. Sealey, Subrata Ghosh, Fakhreddin Jamali, Gopi Shankar, George R. Gunn, Bernd Meibohm
Publikováno v:
Clinical and Experimental Immunology. 184:137-146
Summary Unlike conventional chemical drugs where immunogenicity typically does not occur, the development of anti-drug antibodies following treatment with biologics has led to concerns about their impact on clinical safety and efficacy. Hence the elu
Autor:
Lea Harrington, Le Zheng, Mitsuhiko Ikura, David C.F. Sealey, Michael A. S. Taboski, Jennifer Cruickshank
Publikováno v:
Sealey, D C F, Zheng, L, Taboski, M A S, Cruickshank, J, Ikura, M & Harrington, L A 2010, ' The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization ', Nucleic Acids Research, vol. 38, no. 6, pp. 2019-2035 . https://doi.org/10.1093/nar/gkp1160
Nucleic Acids Research
Nucleic Acids Research
Telomerase defers the onset of telomere damage-induced signaling and cellular senescence by adding DNA onto chromosome ends. The ability of telomerase to elongate single-stranded telomeric DNA depends on the reverse transcriptase domain of TERT, and
Autor:
Gopi Shankar, Subrata Ghosh, David C.F. Sealey, Guangyong Zou, Zhenhua Xu, Vincent T. Ho, Anthony S. Russell, Bernd Meibohm, Dafna D. Gladman, Denis Choquette, Brian G. Feagan
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 42(4)
A biosimilar is intended to be highly similar to a reference biologic such that any differences in quality attributes (i.e., molecular characteristics) do not affect safety or efficacy. Achieving this benchmark for biologics, especially large glycopr
Publikováno v:
BMC Molecular Biology
Sealey, D C F, Kostic, A D, LeBel, C, Pryde, F & Harrington, L 2011, ' The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis ', BMC Molecular Biology, vol. 12, 45 . https://doi.org/10.1186/1471-2199-12-45
BMC Molecular Biology, Vol 12, Iss 1, p 45 (2011)
Sealey, D C F, Kostic, A D, LeBel, C, Pryde, F & Harrington, L 2011, ' The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis ', BMC Molecular Biology, vol. 12, 45 . https://doi.org/10.1186/1471-2199-12-45
BMC Molecular Biology, Vol 12, Iss 1, p 45 (2011)
BackgroundThe first telomerase-associated protein (Est1) was isolated in yeast due to its essential role in telomere maintenance. The human counterparts EST1A, EST1B, and EST1C perform diverse functions in nonsense-mediated mRNA decay (NMD), telomere
Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52
Autor:
Catherine LeBel, David C.F. Sealey, David Lydall, Emanuel Rosonina, Fiona E. Pryde, Laura Maringele, Lea Harrington
Publikováno v:
Genetics. 182(3)
Telomeres are essential features of linear genomes that are crucial for chromosome stability. Telomeric DNA is usually replenished by telomerase. Deletion of genes encoding telomerase components leads to telomere attrition with each cycle of DNA repl